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Influence of Genotype and Haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the Incidence of Breast Cancer - a Case-Control Study in Jordan
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 Title & Authors
Influence of Genotype and Haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the Incidence of Breast Cancer - a Case-Control Study in Jordan
Abuhaliema, Ali M; Yousef, Al-Motassem F; El-Madany, Nirmeen N; Bulatova, Nailya R; Awwad, Nemah M; Yousef, Muhammad A; Al Majdalawi, Khalil Z;
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Background: Breast cancer is the leading cause of cancer death among women and the second in humans worldwide. Many published studies have suggested an association between MDR1 polymorphisms and breast cancer risk. Our aim was to study the association between genetic polymorphism of MDR1 at three sites (C3435T, G2677A/T, and C1236T) and their haplotype and the risk of breast cancer in Jordanian females. Materials and Methods: A case-control study involving 150 breast cancer cases and 150 controls was conducted. Controls were age-matched to cases. The polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) technique and sequencing were performed to analyse genotypes. Results: The distribution of MDR1 C3435T genotypes differed between cases and controls [cases, CC 45.3%, CT 41.3%, and TT 13.3%; controls, CC 13.4%, CT 43.3%, and TT 30.2%, p < 0.001]. Similarly, the distribution of G2677A/T significantly differed [cases, GG 43.1 %, GT+GA 50.9% and AA+TT 6%; controls, GG 29.6 %, GT+GA 50.9%, and AA+TT 19.4%, p
Breast cancer;MDR1;polymorphism;haplotype;Jordan;
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Al-Diab O, Yousef A-M, Al Manassrah E, et al (2015). Genotype and Haplotype analysis of ABCB1 at 1236, 2677 and 3435 among Jordanian population. Trop J Pharm Res, 14, 1013-9. crossref(new window)

Al Rifai RO, Nakamura K (2015). Differences in breast and cervical cancer screening rates in Jordan among Women from different socioeconomic strata: analysis of the 2012 population-based household survey. Asian Pac J Cancer Prev, 16, 6697-704. crossref(new window)

Alsaif AA, Hasan TN, Shafi G, et al (2013). Association of multiple drug resistance-1 gene polymorphism with multiple drug resistance in breast cancer patients from an ethnic Saudi Arabian population. Cancer Epidemiol, 37, 762-6. crossref(new window)

Awwad N, Yousef AM, Abuhaliema A, et al (2015). Relationship between Genetic Polymorphisms in MTHFR (C677T, A1298C and their Haplotypes) and the Incidence Of Breast Cancer among Jordanian Females--Case-Control Study. Asian Pac J Cancer Prev, 16, 5007-11. crossref(new window)

Barrett JC, Fry B, Maller J, et al (2005). Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics, 21, 263-5. crossref(new window)

Cochran G (1954). Some methods for strengthening the common ${\chi}$ tests. Biometrics, 10, 417-51. crossref(new window)

de Oliveira J, Felipe AV, Neto RA, et al (2014). Association between ABCB1 immunohistochemical expression and overall survival in gastric cancer patients. Asian Pac J Cancer Prev, 15, 6935-8. crossref(new window)

Du Y, Su T, Zhao L, et al (2014). Associations of polymorphisms in DNA repair genes and MDR1 gene with chemotherapy response and survival of non-small cell lung cancer.

Fawzy MS, Awad HA, Ahmad HS, et al (2014). Multi-drug resistance 1 genetic polymorphisms gene expression and prediction of chemotherapy response in breast cancer Egyptian patients. Egypt J Biochem Mol Biol, 32, 75-98.

Gaunt TR, Rodriguez S, Zapata C, et al (2006). MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers. BMC Bioinformatics, 7, 227. crossref(new window)

Global Health Estimates, WHO. 2013. [Accessed 14 June 2015].

Gutierrez-Rubio SA, Quintero-Ramos A, Duran-Cardenas A, et al (2015). 1236 C/T and 3435 C/T polymorphisms of the ABCB1 gene in Mexican breast cancer patients. Genet Mol Res, 14, 1250-9. crossref(new window)

Hamidovic A, Hahn K, Kolesar J (2010). Clinical significance of ABCB1 genotyping in oncology. J Oncol Pharm Pract, 16, 39-44. crossref(new window)

Henriquez-Hernandez LA, Murias-Rosales A, Hernandez Gonzalez A, et al (2009). Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: a case-control study. Oncol Rep, 22, 1425-33.

Ikeda M, Tsuji D, Yamamoto K, et al (2015). Relationship between ABCB1 gene polymorphisms and severe neutropenia in patients with breast cancer treated with doxorubicin/cyclophosphamide chemotherapy. Drug Metab Pharmacokinet, 30, 149-53. crossref(new window)

Ji M, Tang J, Zhao J, et al (2012). Polymorphisms in genes involved in drug detoxification and clinical outcomes of anthracycline-based neoadjuvant chemotherapy in Chinese Han breast cancer patients. Cancer Biol Ther, 13, 264-71. crossref(new window)

Kalinsky K, Mayer JA, Xu X, et al (2015). Correlation of hormone receptor status between circulating tumor cells, primary tumor, and metastasis in breast cancer patients. Clin Transl Oncol, 17, 539-46. crossref(new window)

Kim HJ, Im SA, Keam B, et al (2015). ABCB1 polymorphism as prognostic factor in breast cancer patients treated with docetaxel and doxorubicin neoadjuvant chemotherapy. Cancer Sci, 106, 86-93. crossref(new window)

Kim JL, Cho KH, Park EC, et al (2014). A single measure of cancer burden combining incidence with mortality rates for worldwide application. Asian Pac J Cancer Prev, 15, 433-9. crossref(new window)

Kreile M, Rots D, Piekuse L, et al (2014). Lack of association between polymorphisms in genes MTHFR and MDR1 with risk of childhood acute lymphoblastic leukemia. Asian Pac J Cancer Prev, 15, 9707-11. crossref(new window)

Lecarpentier J, Nogues C, Mouret-Fourme E, et al (2015). Breast cancer risk associated with estrogen exposure and truncating mutation location in BRCA1/2 Carriers. Cancer Epidemiol Biomarkers Prev, 24, 698-707. crossref(new window)

Lu PH, Wei MX, Yang J, et al (2011). Association between two polymorphisms of ABCB1 and breast cancer risk in the current studies: a meta-analysis. Breast Cancer Res Treat, 125, 537-43. crossref(new window)

Macias-Gomez NM, Gutierrez-Angulo M, Leal-Ugarte E, et al (2014). MDR1 C3435T polymorphism in Mexican patients with breast cancer. Genet Mol Res, 13, 5018-24. crossref(new window)

Ozdemir S, Uludag A, Silan F, et al (2013). Possible roles of the xenobiotic transporter P-glycoproteins encoded by the MDR1 3435 C>T gene polymorphism in differentiated thyroid cancers. Asian Pac J Cancer Prev, 14, 3213-7. crossref(new window)

Payandeh M, Sadeghi M, Sadeghi E (2015). Differences in prognostic factors between early and late recurrence breast cancers. Asian Pac J Cancer Prev, 16, 6575-9. crossref(new window)

Pongstaporn W, Pakakasama S, Chaksangchaichote P, et al (2015). MDR1 C3435T and C1236T polymorphisms: association with high-risk childhood acute lymphoblastic leukemia. Asian Pac J Cancer Prev, 16, 2839-43. crossref(new window)

Rodriguez S, Gaunt TR, Day IN (2009). Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol, 169, 505-14. crossref(new window)

Rubis B, Holysz H, Barczak W, et al (2012). Study of ABCB1 polymorphism frequency in breast cancer patients from Poland. Pharmacol Rep, 64, 1560-6. crossref(new window)

Salem AH, Ali M, Ibrahim A, et al (2014). Genotype and Allele Frequencies of MDR-1 Gene Polymorphism in Jordanian and Sudanese Populations. American Journal of Medicine Studies, 2, 19-23.

Sufian SN, Masroor I, Mirza W, et al (2015). Evaluation of common risk factors for breast carcinoma in females: a hospital based study in karachi, Pakistan. Asian Pac J Cancer Prev, 16, 6347-52. crossref(new window)

Tulsyan S, Chaturvedi P, Singh AK, et al (2014). Assessment of clinical outcomes in breast cancer patients treated with taxanes: multi-analytical approach. Gene, 543, 69-75. crossref(new window)

Wang J, Wang B, Bi J, et al (2012). MDR1 gene C3435T polymorphism and cancer risk: a meta-analysis of 34 casecontrol studies. J Cancer Res Clin Oncol, 138, 979-89. crossref(new window)

Wang LH, Song YB, Zheng WL, et al (2013a). The association between polymorphisms in the MDR1 gene and risk of cancer: a systematic review and pooled analysis of 52 casecontrol studies. Cancer Cell Int, 13, 46. crossref(new window)

Wang Z, Wang T, Bian J (2013b). Association between MDR1 C3435T polymorphism and risk of breast cancer. Gene, 532, 94-9. crossref(new window)

Wu H, Kang H, Liu Y, et al (2012). Roles of ABCB1 gene polymorphisms and haplotype in susceptibility to breast carcinoma risk and clinical outcomes. J Cancer Res Clin Oncol, 138, 1449-62. crossref(new window)

Zhu CY, Lv YP, Yan DF, et al (2013). Knockdown of MDR1 increases the sensitivity to adriamycin in drug resistant gastric cancer cells. Asian Pac J Cancer Prev, 14, 6757-60. crossref(new window)

Zubor P, Lasabova Z, Hatok J, et al (2007). A polymorphism C3435T of the MDR-1 gene associated with smoking or high body mass index increases the risk of sporadic breast cancer in women. Oncol Rep, 18, 211-7.