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Influence of Genotype and Haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the Incidence of Breast Cancer - a Case-Control Study in Jordan
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 Title & Authors
Influence of Genotype and Haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the Incidence of Breast Cancer - a Case-Control Study in Jordan
Abuhaliema, Ali M; Yousef, Al-Motassem F; El-Madany, Nirmeen N; Bulatova, Nailya R; Awwad, Nemah M; Yousef, Muhammad A; Al Majdalawi, Khalil Z;
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 Abstract
Background: Breast cancer is the leading cause of cancer death among women and the second in humans worldwide. Many published studies have suggested an association between MDR1 polymorphisms and breast cancer risk. Our aim was to study the association between genetic polymorphism of MDR1 at three sites (C3435T, G2677A/T, and C1236T) and their haplotype and the risk of breast cancer in Jordanian females. Materials and Methods: A case-control study involving 150 breast cancer cases and 150 controls was conducted. Controls were age-matched to cases. The polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) technique and sequencing were performed to analyse genotypes. Results: The distribution of MDR1 C3435T genotypes differed between cases and controls [cases, CC 45.3%, CT 41.3%, and TT 13.3%; controls, CC 13.4%, CT 43.3%, and TT 30.2%, p < 0.001]. Similarly, the distribution of G2677A/T significantly differed [cases, GG 43.1 %, GT+GA 50.9% and AA+TT 6%; controls, GG 29.6 %, GT+GA 50.9%, and AA+TT 19.4%, p
 Keywords
Breast cancer;MDR1;polymorphism;haplotype;Jordan;
 Language
English
 Cited by
1.
Association between ABCB1 C3435T polymorphism and breast cancer risk: a Moroccan case-control study and meta-analysis, BMC Genetics, 2016, 17, 1  crossref(new windwow)
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The risk of clopidogrel resistance is associated with ABCB1 polymorphisms but not promoter methylation in a Chinese Han population, PLOS ONE, 2017, 12, 3, e0174511  crossref(new windwow)
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Impact of Genetic Polymorphisms on Phenytoin Pharmacokinetics and Clinical Outcomes in the Middle East and North Africa Region, Drugs in R&D, 2017, 17, 3, 341  crossref(new windwow)
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