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Roles of Galectin-7 in Cancer
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 Title & Authors
Roles of Galectin-7 in Cancer
Kaur, Manpreet; Kaur, Tarnjeet; Kamboj, Sukhdev Singh; Singh, Jatinder;
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 Abstract
Galectins are -galactoside binding lectins that contain one or more carbohydrate recognition domains. As a consequence of sugar-binding properties, galectins exhibit a variety of interactions with glycoproteins, thus playing important roles in various pathological processes. A number of studies have shown roles of galectins in cancer. Galectin-7 is a prototype member of the galectin family implicated in epithelial stratification and cell migration. It can act as a potent dual regulator in different types of cancer. Galectin-7 may contribute either to neoplastic transformation and tumour progression through regulation of cell growth, cell cycle, angiogenesis, apoptosis and cell migration or may have a protective effect in cancer depending on the tissue type. A perusal of the literature indicates particular roles of galectin-7 in carcinomas and melanomas, while contributions await greater exploration in other types of cancers including sarcomas and leukemia. This review collectively summarizes available literature on expression and roles of galectin-7 in different cancers.
 Keywords
Carcinoma;galectin;lectin;lymphoma;Metastasis;
 Language
English
 Cited by
1.
Gastric Carcinoma: Recent Trends in Diagnostic Biomarkers and Molecular Targeted Therapies,;;;;;;;;

Asian Pacific Journal of Cancer Prevention, 2016. vol.17. 7, pp.3053-3060 crossref(new window)
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