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Do VDR Gene Polymorphisms Contribute to Breast Cancer?
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 Title & Authors
Do VDR Gene Polymorphisms Contribute to Breast Cancer?
Shaikh, Fouzia; Baig, Saeeda; Jamal, Qamar;
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 Abstract
Breast cancer is the first or second leading cancer among females across the globe. A large number of studies have been conducted to assess any relationship between vitamin D receptor (VDR) gene polymorphisms and breast cancer development. Epidemiological studies have indicated that ethnic traits exhibited by a group of people with a common ancestry and culture, alter the link between VDR gene and breast cancer. It has been hypothesized that VDR polymorphisms have the capacity to impact both on incidence of breast cancer occurrence and to predict its outcome. A survey was here conducted to assess and compare the impact of vitamin D receptor gene polymorphisms Fok1, Bsm1, Taq1, Apa1 and poly (A) on development of breast cancer. Information was obtained from electronic databases including PubMed and Google Scholar for articles published during the period from 1996 to 2015. This search was achieved by using the terms "genetics", "breast cancer", "VDR gene", "polymorphisms". However, due to inconsistent results, no conclusive statements could be presented about the significance of the VDR genotype as far as the development of breast carcinoma is concerned.
 Keywords
Breast cancer;VDR gene;polymorphisms;impact on development;
 Language
English
 Cited by
1.
Vitamin D and Breast Cancer: Latest Evidence and Future Steps, Breast Cancer: Basic and Clinical Research, 2017, 11, 1178-2234, 117822341774981  crossref(new windwow)
2.
Association of vitamin D receptor gene polymorphisms with breast cancer risk in an Egyptian population, Tumor Biology, 2017, 39, 10, 101042831772773  crossref(new windwow)
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