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Epidemiology Characteristics and Trends of Lung Cancer Incidence in Iran
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 Title & Authors
Epidemiology Characteristics and Trends of Lung Cancer Incidence in Iran
Almasi, Zeinab; Salehiniya, Hamid; Amoori, Neda; Enayatrad, Mostafa;
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Background: Lung cancer is one of the most common cancers in the world and a major cause of death from cancer. One of the important indicators to compare the prevalence and incidence of the disease is a change in the trend. The aim of this study was to investigate the changes in the incidence of lung cancer in Iran. Materials and Methods: This study was conducted based on existing data obtained from a national registry of cancer cases and the Disease Management Center of Ministry of Health in Iran. All cases registered in the country were included during 2003-2008. Incidence rates were reported based on the direct method and standard population of World Health Organization. The study also examined the morphology of common lung cancers. Trends in incidence underwent joinpoint regression analysis. Results: Based on the results of this study, 14,403 cases of lung cancer have been recorded of which 10,582 cases were in men and 3,821 in women. Highest incidence rates were observed in the 80-84 age group. Considerable variation across provinces was evident. In females squamous cell carcinoma (SCC) demonstrated a reduction from 24% to 16% of lesions over the period of study, while adenocarcinoma rose from 21% to 29%. In males a similar reduction in SCC was apparent (42% to 29%, again with increase in AC (13 % to 18%). Conclusions: The results show that the increase in the incidence of lung cancer the trend is that more men than women and in men and may be caused by changes in smoking pattern. The incidence of lung cancer in the North West and West provinces was higher than in other regions.
Incidence;Iran;lung cancer;trend;histopathology;SCC;AC;
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Asian Pacific Journal of Cancer Prevention, 2016. vol.17. 8, pp.3817-3822 crossref(new window)
Alberg A, Ford J, Samet J (2007). Epidemiology of lung cancer. ACCP evidence-based clinical practice guidelines (2nd ed), 132(3 Suppl), 29-55. crossref(new window)

Au J, Mang O, Foo W, et al (2004). Time trends of lung cancer incidence by histologic types and smoking prevalence in Hong Kong 1983-2000. Lung Cancer, 45, 143-52. crossref(new window)

Babaei M, Jaafarzadeh H, Sadjadi A, et al (2009). Cancer Incidence and Mortality in Ardabil: Report of an Ongoing Population-Based Cancer Registry in Iran, 2004-2006. Iranian J Publ Health, 38, 35-45.

Bosetti C, Bertuccio P, Levi F, et al (2008). Cancer mortality in the European Union, 1970-2003, with a joinpoint analysis. Ann Oncol, 19, 631-40.

Chan-Yeung M, Koo L, Ho J, et al (2003). Risk factors associated with lung cancer in Hong Kong. Lung Cancer, 40, 131-40. crossref(new window)

Cruz CD, Tanoue L, Matthay R (2011). Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med, 32, 605-44. crossref(new window)

Du YX, Cha Q, Chen XW, et al (1996). An epidemiological study of risk factors for lung cancer in Guangzhou, China. Lung Cancer, 14, 9-37. crossref(new window)

Fauci, Anthony S (2008). Harrison's principles of internal medicine, McGraw-Hill Medical New York.

Ferlay J, Shin H, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. crossref(new window)

Ferlay J, Shin H, Bray F, et al (2010). GLOBOCAN 2008, cancer incidence and mortality worldwide, Lyon, France, IARC cancerbase no. 10.

Goya MM (2007). Iranian annual cancer registration report 2003/2008, tehran, ministry of health and medical education, health deputy. Center for Disease Control and Prevention.

Hadoux J, Besse B, Planchard D (2011). Lung cancer in never smoker: Epidemiology, molecular profiles and treatment. Presse Med, 40, 371-8. crossref(new window)

Horner M, Ries L, Krapcho M (2009). SEER Cancer [Online]. Bethesda, MD: Based on November 2008 SEER submission data, posted to the SEER website.

Hosseini M, Naghan P, Karimi S, et al ( (2009). Environmental risk factors for lung cancer in Iran: a case-control study. Int J Epidemiol, 38, 989-96. crossref(new window)

Hshyany AA, Farahmand M, Hasanzadeh J, et al (2012). The incidence of lung cancer in the province based on cancer registry data 2001-8. Payesh, 11, 483 - 77.

Hu Z, Wu C, Shi Y, et al (2011). A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet, 43, 792-6. crossref(new window)

Hussain S, Hofseth L, Harris C (2001). Tumor suppressor genes:at the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment. Lung Cancer, 34, 7-15. crossref(new window)

Janssen-Heijnen M, Coebergh J (2003). The changing epidemiology of lung cancer in Europe. Lung Cancer, 41, 245-58. crossref(new window)

Jemal A, Bray F, Center M, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. crossref(new window)

Jiao Z, Hai-Tao W, Bao-Guo L (2014). Prognostic Significance of Circulating Tumor Cells in Small-Cell Lung Cancer Patients:a Meta-analysis. Asian Pac J Cancer Prev, 15, 8429-33. crossref(new window)

Kabat G (1996). Aspects of the epidemiology of lung cancer in smokers and nonsmokers in the United States. Lung Cancer 15, 1-20. crossref(new window)

Kazemi-Lomedasht F, Rami A, Zarghami N (2013). Comparison of inhibitory effect of curcumin nanoparticles and free curcumin in human telomerase reverse transcriptase gene expression in breast cancer. Adv Pharm Bull, 3, 127-30.

Keyghobadi N, Rafiemanesh H, Hafshejani AM, et al (2015). Epidemiology and trend of cancers in the province of Kerman: Southeast of Iran. Asian Pac J Cancer Prev, 16, 1409-13. crossref(new window)

Khajehkazemi R, Sadeghirad B, Karamouzian M (2013). The projection of burden of disease in Islamic Republic of Iran to 2025. PloS ONE, 8, 76881. crossref(new window)

Koohi F, Enayatrad M, Salehiniya H (2015). A Study of the Epidemiology and Trends in Cancer Incidence in Iranian Elderly 2003-2009. Arak Med University J, 18, 57-66.

Koosha A, Farahbakhsh M, Hakimi S, et al (2011). Epidemiology of Cancer in East Azerbaijan province in 2008. Tabriz University Med Sci, 32, 74-9.

Li Y, Sheu C, Ye Y, et al (2010). Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol, 11, 321-30. crossref(new window)

Mehrabani D, Tabei S, Heydari S, et al (2008). Cancer Occurrence in Fars Province, Southern Iran. Iranian Red Crescent Med J, 10, 314-22.

Miki D, Kubo M, Takahashi A, et al (2010). Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nat Genet, 42, 893-6. crossref(new window)

Ming Z, Cui-Huan W, Xiao-Ling Z, et al (2014). Loss of imprinting of insulin-like growth factor 2 is associated with increased risk of primary lung cancer in the central china region. Asian Pac J Cancer Prev, 15, 7799-803. crossref(new window)

Molina J, Yang P, Cassivi S, et al (2008). Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc, 83, 584-94. crossref(new window)

Organization WH (2011). WHO report on the global tobacco epidemic, 2011, warning about the dangers of tobacco. , Geneva, Switzerland, WHO press, 2011.

Parkin DM, Bray F, Ferlay J, et al (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. crossref(new window)

Sadjadi A, Malekzadeh R, Derakhshan M, et al (2003). Cancer occurrence in Ardabil: Results of a population based Cancer Registry from Iran. Int J Cancer, 107, 113-8. crossref(new window)

Seyed Mohsen Mousavi, Gouya MM, Ramazani R, et al (2009). Cancer incidence and mortality in Iran. Ann Oncol, 20, 556-63.

Shiraishi K, Kunitoh H, Daigo Y, et al (2012). A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nat Genet, 44, 900-3. crossref(new window)

Siegel R, Naishadham D, Jemal A (2013). Cancer statistics 2013. CA Cancer J Clin, 63, 11-30. crossref(new window)

Somi M, Farhang S, Mirinezhad S, et al ( 2008). Cancer in East Azerbaijan, Iran: results of a population-based cancer registry. Asian Pac J Cancer Prev, 9(2), 327-30.

Toh C-K ( 2009). The changing epidemiology of lung cancer. Methods Mol Biol, 472, 397-411. crossref(new window)

Toh C, Lim W (2007). Lung cancer in never-smokers. J Clin Pathol, 60, 337-40.

Wahbah M, Boroumand N, Castro C, et al (2007). Changing trends in the distribution of the histologic types of lung cancer: a review of 4439 cases. Ann Diagn Pathol, 11, 89-96. crossref(new window)

Wang SY, Hu Yl, Wu Yl, et al (1996). A comparative study of the risk factors for lung cancer in Guangdong, China. Lung Cancer, 14, 99-105. crossref(new window)

Wang Y, Broderick P, Webb E, et al (2008). Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet, 40, 1407-9. crossref(new window)