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Oridonin Suppresses Proliferation of Human Ovarian Cancer Cells via Blockage of mTOR Signaling
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 Title & Authors
Oridonin Suppresses Proliferation of Human Ovarian Cancer Cells via Blockage of mTOR Signaling
Xia, Rong; Chen, Sun-Xiao; Qin, Qin; Chen, Yan; Zhang, Wei-Wei; Zhu, Rong-Rong; Deng, An-Mei;
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 Abstract
Oridonin, an ent-kaurane diterpenoid compound isolated from the traditional Chinese herb Rabdosia rubescens, has shown various pharmacological and physiological effects such as anti-tumor, anti-bacterial, and anti-inflammatory properties. However, the effect of oridonin on human ovarian cancer cell lines has not been determined. In this study, we demonstrated that oridonin inhibited ovarian cancer cell proliferation, migration and invasion in a dose-dependent manner. Furthermore, we showed oridonin inhibited tumor growth of ovarian cancer cells (SKOV3) in vivo. We then assessed mechanisms and found that oridonin specifically abrogated the phosphorylation/activation of mTOR signaling. In summary, our results indicate that oridonin is a potential inhibitor of ovarian cancer by blocking the mTOR signaling pathway.
 Keywords
Oridonin;ovarian cancer;mTOR signal pathway;suppress proliferation;
 Language
English
 Cited by
1.
Oridonin induces apoptosis in human oral cancer cells via phosphorylation of histone H2AX, European Journal of Oral Sciences, 2017, 125, 6, 438  crossref(new windwow)
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