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Role of the Mdm2 SNIP 309 Polymorphism in Gastric Mucosal Morphologic Patterns of Patients with Helicobacter pylori Associated Gastritis
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 Title & Authors
Role of the Mdm2 SNIP 309 Polymorphism in Gastric Mucosal Morphologic Patterns of Patients with Helicobacter pylori Associated Gastritis
Tongtawee, Taweesak; Dechsukhum, Chavaboon; Leeanansaksiri, Wilairat; Kaewpitoon, Soraya; Kaewpitoon, Natthawut; Loyd, Ryan A; Matrakool, Likit; Panpimanmas, Sukij;
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Background: The tumor suppressor p53 is as a regulator of cell proliferation, apoptosis and many other biological processes as well as external and internal stress responses. Mdm2 SNIP309 is a negative regulator of 53. Therefore, this study aimed to determine the role of the Mdm2 SNIP 309 polymorphism in the gastric mucosal morphological patterns in patients with Helicobacter pylori associated gastritis. Materials and Methods: A prospective cross-sectional study was carried out from November 2014 through November 2015. Biopsy specimens were obtained from patients and infection was proven by positive histology. Gastric mucosa specimens were sent to the Molecular Genetics Unit, Institute of Medicine, Suranaree University of Technology where they were tested by molecular methods to detect the patterns of Mdm2 SNIP 309 polymorphism using the real-time PCR hybridization probe method. The results were analyzed and correlated with gastric mucosal morphological patterns by using C-NBI endoscopy. Results: A total of 300 infected patients were enrolled and gastric mucosa specimens were collected. In this study the percentage of Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous was 78% and 19 % respectively whereas Mdm2 SNIP309 G/G homozygous was 3%. Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygosity correlated with type 1 to type 3 gastric mucosal morphological patterns (P<0.01) whereas Mdm2 SNIP309 G/G homozygous correlated with type 4 and type 5 (P<0.01). Conclusions: Our study finds the frequency of Mdm2 SNIP309 G/G in a Thai population is very low, and suggests that this can explain ae Thailand enigma. Types 1 to type 3 are the most common gastric mucosal morphological patterns according to the unique genetic polymorphism of MDM2 SNIP 309 in the Thai population.
MDM2 SNIP 309;gastric mucosal morphologic patterns;H. pylori;C-NBI endoscopy;
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Asian Pacific Journal of Cancer Prevention, 2016. vol.17. 7, pp.3391-3394 crossref(new window)
Bond GL, Hu W, Levine AJ, et al (2005). MDM2 is a central node in the p53 pathway: 12 years and counting. Curr Cancer Drug Targets, 5, 3-8. crossref(new window)

Gono K, Obi T, Yamaguchi M, et al (2004). Appearance of enhanced tissue features in narrow-band endoscopic imaging. J Biomed Opt, 9, 568-77. crossref(new window)

Gurova KV, Hill JE, Guo C, et al (2005). Small molecules that reactivate p53 in renal cell carcinoma reveals a nf-kappab-dependent mechanism of p53 suppression in tumors. Proc Natl Acad Sci USA., 102, 17448-53. crossref(new window)

Haupt Y, Maya R, et al (1997). Mdm2 promotes the rapid degradation of p53. Nature, 387, 296-9. crossref(new window)

Honda R, Tanaka H, et al (1997). Oncoprotein MDM2 is an ubiquitin ligase E3 for tumor suppressor p53. FEBS Letters, 420, 25-7. crossref(new window)

Kentaro S, Jan T, Ernst JK, et al (2015). Kyoto global consensus report on Helicobacter pylori gastritis. Gut, 64, 1353-67. crossref(new window)

Komarova EA, Krivokrysenko V, Wang K, et al (2005). P53 is a suppressor of inflammatory response in mice. FASEB J, 19, 1030-2. crossref(new window)

Kubbutat MH, Jones SN, et al (1997). Regulation of p53 stability by Mdm2. Nature, 387, 299-303. crossref(new window)

MF Dixon, RM Genta JH, Harley et al (1996). "Classification and grading of gastritis. The Updated Sydney system. Am J Surgical Pathol, 20, 1161-81.

Momand J, Zambetti GP, et al (1992). The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell, 69, 1237- 45. crossref(new window)

Moradi MT, Salehi Z, Aminian K, et al (2014). Effects of p53 codon 72 and MDM2 SNP309 polymorphisms on gastric cancer risk among the Iranian population. Asian Pac J Cancer Prev, 15, 7413-7. crossref(new window)

O'Prey J, Crighton D, Martin AG, et al (2010). P53-mediated induction of noxa and p53aip1 requires nfkappab. Cell Cycle, 9, 947-52. crossref(new window)

Picksley SM, Lane DP et al (1993).The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53? Bioessays, 15, 689-90. crossref(new window)

Taweesak T, Soraya K, Natthawut K, et al (2015). Correlation between gastric mucosal morphologic patterns and histopathological severity of helicobacter pylori associated gastritis using conventional narrow band imaging gastroscopy. Bio Med Res Int, 7, 42-8.

Tergaonkar V, Pando M, Vafa O, et al (2002). P53 stabilization is decreased upon nf kappa b activation: A role for nfkappab in acquisition of resistance to chemotherapy. Cancer Cell, 1, 493-503. crossref(new window)

Wang X, Yang J, Ho B, et al (2009). Interaction of Helicobacter pylori with genetic variants in the MDM2 promoter is associated with gastric cancer susceptibility in Chinese patients. Helicobacter, 14, 114-9.

Yagi K, Nakamura A, Sekine A, et al (2002). Comparison between magnifying endoscopy and histological, culture and urease test findings from the gastric mucosa of the corpus. Endoscopy, 34, 376-81. crossref(new window)