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Distribution of KRAS and BRAF Mutations in Metastatic Colorectal Cancers in Turkish Patients
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 Title & Authors
Distribution of KRAS and BRAF Mutations in Metastatic Colorectal Cancers in Turkish Patients
Gorukmez, Orhan; Yakut, Tahsin; Gorukmez, Ozlem; Sag, Sebnem Ozemri; Karkucak, Mutlu; Kanat, Ozkan;
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The results of this study demonstrate the potential prognostic and predictive values of KRAS and BRAF gene mutations in patients with colorectal cancer (CRC). It has been proven that KRAS and BRAF mutations are predictive biomarkers for resistance to anti-EGFR monoclonal antibody treatment in patients with metastatic CRC (mCRC). We demonstrated the distribution of KRAS (codons 12, 13 and 61) and BRAF (codon 600) gene mutations in 50 mCRCs using direct sequencing and compared the results with clinicopathological data. KRAS and BRAF mutations were identified in 15 (30%) and 1 (2%) patients, respectively. We identified KRAS mutations in codon 12, 13 and 61 in 73.3% (11/15), 20% (3/15) and 6.67% (1/15) of the positive patients, respectively. The KRAS mutation frequency was significantly higher in tumors located in the ascending colon (p
Metastatic colorectal cancer;mutations;BRAF;KRAS;clinicopathological variables;
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