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Survival of Colorectal Cancer in the Presence of Competing-Risks - Modeling by Weibull Distribution
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 Title & Authors
Survival of Colorectal Cancer in the Presence of Competing-Risks - Modeling by Weibull Distribution
Baghestani, Ahmad Reza; Daneshvar, Tahoura; Pourhoseingholi, Mohamad Amin; Asadzadeh, Hamid;
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Background: Colorectal cancer (CRC) is the commonest malignancy in the lower gastrointestinal tract in both men and women. It is the third leading cause of cancer-dependent death in the world. In Iran the incidence of colorectal cancer has increased during the last 25 years. Materials and Methods: In this article we analyzed the survival of 447 colorectal patients of Taleghani hospital in Tehran using parametric competing-risks models. The cancers of these patients were diagnosed during 1985 - 2012 and followed up to 2013. The purpose was to assess the association between survival of patients with colorectal cancer in the presence of competing-risks and prognostic factors using parametric models. The analysis was carried out using R software version 3.0.2. Results: The prognostic variables included in the model were age at diagnosis, tumour site, body mass index and sex. The effect of age at diagnosis and body mass index on survival time was statistically significant. The median survival for Iranian patients with colorectal cancer is about 20 years. Conclusions: Survival function based on Weibull model compared with Kaplan-Meier survival function is smooth. Iranian data suggest a younger age distribution compared to Western reports for CRC.
Survival analysis;colorectal cancer;parametric competing-risks;
 Cited by
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Asian Pacific Journal of Cancer Prevention, 2016. vol.17. 7, pp.3647-3650 crossref(new window)
Application of the Parametric Regression Model with the Four-Parameter Log-Logistic Distribution for Determining of the Effecting Factors on the Survival Rate of Colorectal Cancer Patients in the Presence of Competing Risks, Iranian Red Crescent Medical Journal, 2017, 19, 6  crossref(new windwow)
Abdifard E, Ghaderi S, Hosseini S, Heidari M (2013). Incidence trends of colorectal cancer in the West of Iran during 2000-2005. Asian Pac J Cancer Prev, 14, 1807-11. crossref(new window)

Azadeh S, Moghimi-Dehkordi B, Fatem SR, et al (2008). Colorectal cancer in Iran: an epidemiological study. Asian Pac J Cancer Prev, 9, 123-6.

Baghestani AR, Daneshvar T, Pourhoseingholi MA, Asadzade H (2014). Survival of colorectal cancer patients in the presence of competing-risk. Asian Pac J Cancer Prev, 15, 6253. crossref(new window)

Baghestani AR, Hajizadeh E, Fatemi SR (2010). Parametric model to analyse the survival of gastric cancer in the presence of interval censoring. Tumori, 96, 433-7. crossref(new window)

Caan B, Coates A, Slattery M, et al (1998). Body size and the risk of colon cancer in a large case-control study. Int J Obesity Related Metabolic Disorders, 22, 178-84. crossref(new window)

Center MM, Jemal A, Smith RA, Ward E (2009). Worldwide variations in colorectal cancer. CA Cancer J Clin, 59, 366-78. crossref(new window)

Chan K, Dassanayake B, Deen R, et al (2010). Young patients with colorectal cancer have poor survival in the first twenty months after operation and predictable survival in the medium and long-term: analysis of survival and prognostic markers. World J Surg Oncol, 8, 20840793.

Crowder MJ. Classical competing risks. CRC Press, 2010.

David G Kleinbaum MK. Survivale analysis. springer. Issue, Page ??

Golfam F, Golfam P, Neghabi Z (2013). Frequency of all types of colorectal tumors in the patients referred to selected hospitals in Tehran. Iranian Red Crescent Med J, 15, 473. crossref(new window)

Heidarnia MA, Monfared ED, Akbari ME, et al (2013). Social determinants of health and 5-year survival of colorectal cancer. Asian Pac J Cancer Prev, 14, 5111-6. crossref(new window)

Khattak MA, Martin HL, Beeke C, et al (2012). Survival differences in patients with metastatic colorectal cancer and with single site metastatic disease at initial presentation: results from South Australian clinical registry for advanced colorectal cancer. Clin Colorectal Cancer, 11, 247-54. crossref(new window)

Labianca R, Merelli B (2010). Screening and diagnosis for colorectal cancer: present and future. Tumori, 96, 889. crossref(new window)

Li XP, Xie ZY, Fu YF, et al (2013). Colorectal cancer concealment predicts a poor survival: a retrospective study. Asian Pac J Cancer Prev, 14, 4157-60. crossref(new window)

Maller RA, Zhou X (2002). Analysis of parametric models for competing risks. Statistica Sinica, 12, 725-50.

McDevitt J, Sharp L, MacDonald D, Dwane F, Comber H (2013). Factors affecting receipt of a medical card in a cohort of colorectal cancer patients, 2002-2006. Irish Med J, 106, 110-3.

Moeschberger ML, Klein J (2003). Survival analysis: Techniques for censored and truncated data: Statistics for Biology Health. Springer.

Moradi A, Khayamzadeh M, Guya M, Mirzaei HR, Salmanian R, Rakhsha A, et al (2009). Survival of colorectal cancer in Iran. Asian Pac J Cancer Prev, 10583-6.

Morrison DS, Parr CL, Lam TH, et al (2013). Behavioural and metabolic risk factors for mortality from colon and rectum cancer: analysis of data from the Asia-pacific cohort studies collaboration. Asian Pac J Cancer Prev, 14, 1083-7. crossref(new window)

Mousavi SM, Gouya MM, Ramazani R, Davanlou M, Hajsadeghi N, Seddighi Z (2009). Cancer incidence and mortality in Iran. Ann Oncol, 20, 556-63.

Nilsen TL, Vatten LJ (2001). Prospective study of colorectal cancer risk and physical activity, diabetes, blood glucose and BMI: exploring the hyperinsulinaemia hypothesis. British J Cancer, 84, 417. crossref(new window)

Pourhoseingholi MA, Zali MR (2012). Colorectal cancer screening: Time for action in Iran. World J Gastrointestinal Oncol, 4, 82-3. crossref(new window)

Ranjbar1, R, Saberfar E, Shamsaie A, Ghasemian E (2014). The aetiological role of human papillomavirus in colorectal carcinoma: an iranian population-based case control study. Asian Pac J Cancer Prev, 15, 1521-5. crossref(new window)

Safaee A, Fatemi SR, Ashtari S, Vahedi M, Moghimi-Dehkordi B, Zali MR (2012). Four years incidence rate of colorectal cancer in Iran: a survey of national cancer registry data-implications for screening. Asian Pac J Cancer Prev, 13, 2695-8. crossref(new window)

Sung JJ, Lau JY, Goh K, Leung W (2005). Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol, 6, 871-6. crossref(new window)