Advanced SearchSearch Tips
The Neutrophil to Lymphocyte Ratio is an Independent Prognostic Factor in Patients with Metastatic Gastric Cancer
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
The Neutrophil to Lymphocyte Ratio is an Independent Prognostic Factor in Patients with Metastatic Gastric Cancer
Musri, Fatma Yalcin; Mutlu, Hasan; Eryilmaz, Melek Karakurt; Salim, Derya Kivrak; Gunduz, Seyda; Coskun, Hasan Senol;
  PDF(new window)
Inflammation can play an important role in cancer progression and the prognostic importance of neutrophil to lymphocyte ratio (NLR), a marker of inflammation, in cancer is a current investigation topic. In the present study, we aimed to determine whether there is a prognostic link between NLR and metastatic gastric cancer (mGC). A total of 143 patients from the Akdeniz University and Antalya Training and Research Hospital database were retrospectively analyzed. The median NLR value was 3.34. The median overall survival (OS) and median progression-free survival (PFS) were 11.6 and 7.9 months, respectively, in patients with NLR<3.34 while these values were 8.3 and 6.2 months respectively in patients with NLR>3.34 (p<0.001 and p
Gastric cancer;neutrophil-to-lymphocyte ratio;progression-free survival;overall survival;
 Cited by
Cho IR, Park JC, Park CH, et al (2014). Pre-treatment neutrophil to lymphocyte ratio as a prognostic marker to predict chemotherapeutic response and survival outcomes in metastatic advanced gastric cancer. Gastric Cancer, 17, 703-10 crossref(new window)

Colotta F, Allavena P, Sica A, et al (2009). Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis, 30, 1073-81. crossref(new window)

Fogar P, Sperti C, Basso D, et al (2006). Decreased total lymphocytecounts in pancreatic cancer: an index of adverse outcome. Pancreas, 32, 22-8. crossref(new window)

Grivennikov SI, Greten FR, Karin M (2010). Immunity, inflammation, and cancer. Cell, 140, 883-99 crossref(new window)

Gomez D, Farid S, Malik HZ, et al (2008). Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor aftercurative resection for hepatocellular carcinoma. World J Surg, 32, 1757-62 crossref(new window)

Hanahan D, Weinberg RA (2011) .Hallmarks of cancer: the next generation. Cell, 144, 646-74. crossref(new window)

Herszenyi L, Tulassay Z (2010) . Epidemiology of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci, 14, 249-58.

Jung MR, Park YK, Jeong O, et al (2011). Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer. J Surg Oncol, 104, 504-10. crossref(new window)

Kaya V, Yildirim M, Demirpence O, et al (2013). Prognostic significance of basic laboratory methods in non- small-cell-lung cancer. Asian Pac J Cancer Prev, 14, 5473-6. crossref(new window)

Kishi Y, Kopetz S, Chun YS, et al (2009). Blood neutrophil-to-lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy. Ann Surg Oncol, 16, 614-22. crossref(new window)

Martinet L, Garrido I, Filleron T, et al (2011). Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer. Cancer Res, 71, 5678-87. crossref(new window)

Nakano K, Hosoda M, Yamamoto M, et al (2014) . Prognostic significance of pre-treatment neutrophil: lymphocyte ratio in Japanese patients with breast cancer. Anticancer Res, 34, 3819-24.

Ozdemir Y, Akin ML, Sucullu I, et al (2014). Pretreatment neutrophil/lymphocyte ratio as a prognostic aid in colorectal cancer. Asian Pac J Cancer Prev, 15, 2647-50. crossref(new window)

Roxburgh CS, McMillan DC (2010) . Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol, 6,149-63. crossref(new window)

Sarraf KM, Belcher E, Raevsky E ,et al (2009). Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer. J Thorac Cardiovasc Surg, 137, 425-8. crossref(new window)

Shimada H, Takiguchi N, Kainuma O, et al (2010). High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer. Gastric Cancer, 13, 170-6. crossref(new window)

Smyth MJ, Dunn GP, Schreiber RD (2006). Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity. Adv Immunol, 90, 1-50. crossref(new window)

Templeton AJ, McNamara MG, Seruga B, et al (2014). Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst, 106, 124. crossref(new window)

Vigano A, Bruera E, Jhangri GS, et al (2000). Clinical survival predictors in patients with advanced cancer. Arch Intern Med, 160, 861-8. crossref(new window)

Yamanaka T, Matsumoto S, Teramukai S, et al (2007). The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncol, 73, 215-20. crossref(new window)