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Significance of Proliferation Markers and Prognostic Factors in Egyptian Patients with Multiple Myeloma
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 Title & Authors
Significance of Proliferation Markers and Prognostic Factors in Egyptian Patients with Multiple Myeloma
Abdelgawad, Iman A; Radwan, Noha H; Shafik, Roxan E; Shokralla, Hala A;
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Background: Multiple myeloma (MM) is influenced by genetic and micro-environmental changes. Malignant plasma cells produce an abnormal monoclonal immunoglobulin, as well as cytokines, such as IL-10 and IL-6 which stimulate cells of the bone marrow microenvironment (BMM) and cause dysfunction and failure of many organs. B cell activating factor (BAFF), IL6 and IL10 are known to influence the growth and survival of malignant clones. Aim: The objectives of the present study were to investigate the circulating levels of BAFF, IL-10 and IL-6, correlate them with well-known parameters of disease activity in patients with MM, and to detect their impact on patients` survival. Materials and Methods: This study was conducted on 89 newly diagnosed MM patients and seventy apparently healthy volunteers as a normal control group. BAFF, IL6, IL10 were measured by ELISA for both groups and survival analysis was performed for all patients. Results: Studied markers were higher in the MM patients compared to the normal control subjects. Patients survival was improved by high serum BAFF levels. Conclusions: High levels of BAFF were found to improve patients` survival. BAFF and IL-6 can be considered probable diagnostic markers for MM.
Multiple myeloma;BAFF;IL6;IL10;
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