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Microchips and their Significance in Isolation of Circulating Tumor Cells and Monitoring of Cancers
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 Title & Authors
Microchips and their Significance in Isolation of Circulating Tumor Cells and Monitoring of Cancers
Sahmani, Mehdi; Vatanmakanian, Mousa; Goudarzi, Mehdi; Mobarra, Naser; Azad, Mehdi;
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 Abstract
In micro-fluid systems, fluids are injected into extremely narrow polymer channels in small amounts such as micro-, nano-, or pico-liter scales. These channels themselves are embedded on tiny chips. Various specialized structures in the chips including pumps, valves, and channels allow the chips to accept different types of fluids to be entered the channel and along with flowing through the channels, exert their effects in the framework of different reactions. The chips are generally crystal, silicon, or elastomer in texture. These highly organized structures are equipped with discharging channels through which products as well as wastes of the reactions are secreted out. A particular advantage regarding the use of fluids in micro-scales over macro-scales lies in the fact that these fluids are much better processed in the chips when they applied as micro-scales. When the laboratory is miniaturized as a microchip and solutions are injected on a micro-scale, this combination makes a specialized construction referred to as "lab-on-chip". Taken together, micro-fluids are among the novel technologies which further than declining the costs; enhancing the test repeatability, sensitivity, accuracy, and speed; are emerged as widespread technology in laboratory diagnosis. They can be utilized for monitoring a wide spectrum of biological disorders including different types of cancers. When these microchips are used for cancer monitoring, circulatory tumor cells play a fundamental role.
 Keywords
Microchips;cancer;circulating tumor cells;monitoring;
 Language
English
 Cited by
1.
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 References
1.
Aitman TJ (2001). DNA microarrays in medical practice. BMJ, 323, 611-5. crossref(new window)

2.
Alexis F, Rhee JW, Richie JP, et al (2008). New frontiers in nanotechnology for cancer treatment. Urol Oncol, 26, 74-85. crossref(new window)

3.
Alizadeh AA, Eisen MB, Davis RE, et al (2000). Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature, 403, 503-11. crossref(new window)

4.
Allan AL, Keeney M (2010). Circulating tumor cell analysis: technical and statistical considerations for application to the clinic. J Oncol, 2010, 426218.

5.
Allen-Mersh TG, McCullough TK, Patel H, et al (2007). Role of circulating tumour cells in predicting recurrence after excision of primary colorectal carcinoma. Br J Surg, 94, 96-105. crossref(new window)

6.
Azad M, Bakhshi Biniaz R, Goudarzi M, et al (2015). Short view of leukemia diagnosis and treatment in iran. Int J Hematol Oncol Stem Cell Res, 9, 88-94.

7.
Backhouse CJ, Crabtree HJ, Glerum DM (2002). Frontal analysis on a microchip. Analyst, 127, 1169-75. crossref(new window)

8.
Bean P (2001). Biochips 2001: the second-generation chip for the clinic. Am Clin Lab, 20, 11-2.

9.
Bhagat AA, Hou HW, Li LD, et al (2011). Pinched flow coupled shear-modulated inertial microfluidics for high-throughput rare blood cell separation. Lab Chip, 11, 1870-8. crossref(new window)

10.
Brivio M, Verboom W, Reinhoudt DN (2006). Miniaturized continuous flow reaction vessels: influence on chemical reactions. Lab Chip, 6, 329-44. crossref(new window)

11.
Brouzes E, Medkova M, Savenelli N, et al (2009). Droplet microfluidic technology for single-cell high-throughput screening. Proc Natl Acad Sci U S A, 106, 14195-200. crossref(new window)

12.
Bunger S, Zimmermann M, Habermann JK (2015). Diversity of assessing circulating tumor cells (CTCs) emphasizes need for standardization: a CTC Guide to design and report trials. Cancer Metastasis Rev, 34, 527-45. crossref(new window)

13.
Chen CL, Chen KC, Pan YC, et al (2011a). Separation and detection of rare cells in a microfluidic disk via negative selection. Lab Chip, 11, 474-83. crossref(new window)

14.
Chen KC, Lee TP, Pan YC, et al (2011b). Detection of circulating endothelial cells via a microfluidic disk. Clin Chem, 57, 586-92. crossref(new window)

15.
Chiu TK, Lei KF, Hsieh CH, et al (2015). Development of a microfluidic-based optical sensing device for label-free detection of circulating tumor cells (CTCs) through their lactic acid metabolism. Sensors (Basel), 15, 6789-806. crossref(new window)

16.
Chuang WC, Lee HL, Chang PZ, et al (2010). Review on the modeling of electrostatic MEMS. Sensors (Basel), 10, 6149-71. crossref(new window)

17.
Cibilic D (2000). Microchip action. Aust Vet J, 78, 598.

18.
de Bono JS, Attard G, Adjei A, et al (2007). Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor. Clin Cancer Res, 13, 3611-6. crossref(new window)

19.
den Toonder J (2011). Circulating tumor cells: the Grand Challenge. Lab Chip, 11, 375-7. crossref(new window)

20.
DeRisi J, Penland L, Brown PO, et al (1996). Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat Genet, 14, 457-60. crossref(new window)

21.
Dharmasiri U, Balamurugan S, Adams AA, et al (2009). Highly efficient capture and enumeration of low abundance prostate cancer cells using prostate-specific membrane antigen aptamers immobilized to a polymeric microfluidic device. Electrophoresis, 30, 3289-300. crossref(new window)

22.
Dharmasiri U, Njoroge SK, Witek MA, et al (2011). High-throughput selection, enumeration, electrokinetic manipulation, and molecular profiling of low-abundance circulating tumor cells using a microfluidic system. Anal Chem, 83, 2301-9. crossref(new window)

23.
Di Carlo D, Wu LY, Lee LP (2006). Dynamic single cell culture array. Lab Chip, 6, 1445-9. crossref(new window)

24.
Dingwall R (1979). Are you ready for the microchip? Nurs Times, 75, 975-6.

25.
Emmert-Buck MR, Bonner RF, Smith PD, et al (1996). Laser capture microdissection. Science, 274, 998-1001. crossref(new window)

26.
Fabian TK, Fejerdy P, Csermely P (2008). Salivary Genomics, Transcriptomics and Proteomics: The Emerging Concept of the Oral Ecosystem and their Use in the Early Diagnosis of Cancer and other Diseases. Curr Genomics, 9, 11-21. crossref(new window)

27.
Fey MF (2002). The impact of chip technology on cancer medicine. Ann Oncol, 13, 109-13.

28.
Figeys D, Pinto D (2000). Lab-on-a-chip: a revolution in biological and medical sciences. Anal Chem, 72, 330A-5A.

29.
Gleghorn JP, Pratt ED, Denning D, et al (2010). Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody. Lab Chip, 10, 27-9. crossref(new window)

30.
Gomez-Sjoberg R, Leyrat AA, Pirone DM, et al (2007). Versatile, fully automated, microfluidic cell culture system. Anal Chem, 79, 8557-63. crossref(new window)

31.
Goodale D, Phay C, Postenka CO, et al (2009). Characterization of tumor cell dissemination patterns in preclinical models of cancer metastasis using flow cytometry and laser scanning cytometry. Cytometry A, 75, 344-55.

32.
Gross A, Schoendube J, Zimmermann S, et al (2015). Technologies for Single-Cell Isolation. Int J Mol Sci, 16, 16897-919. crossref(new window)

33.
Guzman NA, Phillips TM (2011). Immunoaffinity capillary electrophoresis: a new versatile tool for determining protein biomarkers in inflammatory processes. Electrophoresis, 32, 1565-78.

34.
Helo P, Cronin AM, Danila DC, et al (2009). Circulating prostate tumor cells detected by reverse transcription-PCR in men with localized or castration-refractory prostate cancer: concordance with CellSearch assay and association with bone metastases and with survival. Clin Chem, 55, 765-73. crossref(new window)

35.
Holden C (1989). Engineers' nobel to microchip pioneers. Science, 246, 214.

36.
Hosokawa M, Hayata T, Fukuda Y, et al (2010). Size-selective microcavity array for rapid and efficient detection of circulating tumor cells. Anal Chem, 82, 6629-35. crossref(new window)

37.
Huang F, Adelman J, Jiang H, et al (1999). Identification and temporal expression pattern of genes modulated during irreversible growth arrest and terminal differentiation in human melanoma cells. Oncogene, 18, 3546-52. crossref(new window)

38.
Hung LY, Chuang YH, Kuo HT, et al (2013). An integrated microfluidic platform for rapid tumor cell isolation, counting and molecular diagnosis. Biomed Microdevices, 15, 339-52. crossref(new window)

39.
Hur SC, Henderson-MacLennan NK, McCabe ER, et al (2011). Deformability-based cell classification and enrichment using inertial microfluidics. Lab Chip, 11, 912-20. crossref(new window)

40.
Kang JH, Krause S, Tobin H, et al (2012). A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells. Lab Chip, 12, 2175-81. crossref(new window)

41.
Kanwar SS, Dunlay CJ, Simeone DM, et al (2014). Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes. Lab Chip, 14, 1891-900. crossref(new window)

42.
Kartalov EP, Zhong JF, Scherer A, et al (2006). High-throughput multi-antigen microfluidic fluorescence immunoassays. Biotechniques, 40, 85-90. crossref(new window)

43.
Kim H, Lee S, Lee JH, et al (2015). Integration of a microfluidic chip with a size-based cell bandpass filter for reliable isolation of single cells. Lab Chip, 15, 4128-32. crossref(new window)

44.
Kim YJ, Koo GB, Lee JY, et al (2014). A microchip filter device incorporating slit arrays and 3-D flow for detection of circulating tumor cells using CAV1-EpCAM conjugated microbeads. Biomaterials, 35, 7501-10. crossref(new window)

45.
Kuo JS, Chiu DT (2011). Disposable microfluidic substrates: transitioning from the research laboratory into the clinic. Lab Chip, 11, 2656-65. crossref(new window)

46.
Kuo JS, Zhao Y, Schiro PG, et al (2010). Deformability considerations in filtration of biological cells. Lab Chip, 10, 837-42. crossref(new window)

47.
Li Y, Zheng Q, Bao C, et al (2015). Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res, 25, 981-4. crossref(new window)

48.
Lianidou ES, Markou A, Strati A (2015). The Role of CTCs as Tumor Biomarkers. Adv Exp Med Biol, 867, 341-67. crossref(new window)

49.
Liu RH, Yang J, Lenigk R, et al (2004). Self-contained, fully integrated biochip for sample preparation, polymerase chain reaction amplification, and DNA microarray detection. Anal Chem, 76, 1824-31. crossref(new window)

50.
Mach AJ, Adeyiga OB, Di Carlo D (2013). Microfluidic sample preparation for diagnostic cytopathology. Lab Chip, 13, 1011-26. crossref(new window)

51.
Maheswaran S, Haber DA (2010). Circulating tumor cells: a window into cancer biology and metastasis. Curr Opin Genet Dev, 20, 96-9. crossref(new window)

52.
Maheswaran S, Sequist LV, Nagrath S, et al (2008). Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med, 359, 366-77. crossref(new window)

53.
Mair DA, Geiger E, Pisano AP, et al (2006). Injection molded microfluidic chips featuring integrated interconnects. Lab Chip, 6, 1346-54. crossref(new window)

54.
Marques MP, Fernandes P (2011). Microfluidic devices: useful tools for bioprocess intensification. Molecules, 16, 8368-401. crossref(new window)

55.
Meng S, Tripathy D, Shete S, et al (2004). HER-2 gene amplification can be acquired as breast cancer progresses. Proc Natl Acad Sci U S A, 101, 9393-8. crossref(new window)

56.
Meng S, Tripathy D, Shete S, et al (2006). uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues. Proc Natl Acad Sci U S A, 103, 17361-5. crossref(new window)

57.
Minhas H (2015). Developing the Lab on a Chip-microTAS community. Lab Chip, 15, 15-6. crossref(new window)

58.
Moon HS, Kwon K, Kim SI, et al (2011). Continuous separation of breast cancer cells from blood samples using multi-orifice flow fractionation (MOFF) and dielectrophoresis (DEP). Lab Chip, 11, 1118-25. crossref(new window)

59.
Mrksich M, Whitesides GM (1996). Using self-assembled monolayers to understand the interactions of man-made surfaces with proteins and cells. Annu Rev Biophys Biomol Struct, 25, 55-78. crossref(new window)

60.
Muluneh M, Issadore D (2014). Microchip-based detection of magnetically labeled cancer biomarkers. Adv Drug Deliv Rev, 66, 101-9. crossref(new window)

61.
Munro NJ, Snow K, Kant JA, et al (1999). Molecular diagnostics on microfabricated electrophoretic devices: from slab gel- to capillary- to microchip-based assays for T- and B-cell lymphoproliferative disorders. Clin Chem, 45, 1906-17.

62.
Myung JH, Launiere CA, Eddington DT, et al (2010). Enhanced tumor cell isolation by a biomimetic combination of E-selectin and anti-EpCAM: implications for the effective separation of circulating tumor cells (CTCs). Langmuir, 26, 8589-96. crossref(new window)

63.
Nagrath S, Sequist LV, Maheswaran S, et al (2007). Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature, 450, 1235-9. crossref(new window)

64.
Nandi P, Lunte SM (2009). Recent trends in microdialysis sampling integrated with conventional and microanalytical systems for monitoring biological events: a review. Anal Chim Acta, 651, 1-14. crossref(new window)

65.
Ng AH, Wheeler AR (2015). Next-generation microfluidic point-of-care diagnostics. Clin Chem, 61, 1233-4. crossref(new window)

66.
Nge PN, Rogers CI, Woolley AT (2013). Advances in microfluidic materials, functions, integration, and applications. Chem Rev, 113, 2550-83. crossref(new window)

67.
Nind F (1999). Microchip identification. Vet Rec, 145, 532.

68.
Pantel K, Brakenhoff RH, Brandt B (2008). Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer, 8, 329-40. crossref(new window)

69.
Pappalardo PA, Bonner R, Krizman DB, et al (1998). Microdissection, microchip arrays, and molecular analysis of tumor cells (primary and metastases). Semin Radiat Oncol, 8, 217-23. crossref(new window)

70.
Payne RE, Yague E, Slade MJ, et al (2009). Measurements of EGFR expression on circulating tumor cells are reproducible over time in metastatic breast cancer patients. Pharmacogenomics, 10, 51-7. crossref(new window)

71.
Ratajczak J, Wysoczynski M, Hayek F, et al (2006). Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia, 20, 1487-95. crossref(new window)

72.
Reyes DR, Iossifidis D, Auroux PA, et al (2002). Micro total analysis systems. 1. Introduction, theory, and technology. Anal Chem, 74, 2623-36. crossref(new window)

73.
Saliba AE, Saias L, Psychari E, et al (2010). Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays. Proc Natl Acad Sci U S A, 107, 14524-9. crossref(new window)

74.
Sato K, Tokeshi M, Kimura H, et al (2001). Determination of carcinoembryonic antigen in human sera by integrated bead-bed immunoassay in a microchip for cancer diagnosis. Anal Chem, 73, 1213-8. crossref(new window)

75.
Sato K, Yamanaka M, Takahashi H, et al (2002). Microchip-based immunoassay system with branching multichannels for simultaneous determination of interferon-gamma. Electrophoresis, 23, 734-9. crossref(new window)

76.
Seemann R, Brinkmann M, Pfohl T, et al (2012). Droplet based microfluidics. Rep Prog Phys, 75, 016601. crossref(new window)

77.
Seigneuric R, Markey L, Nuyten DS, et al (2010). From nanotechnology to nanomedicine: applications to cancer research. Curr Mol Med, 10, 640-52. crossref(new window)

78.
Sheng W, Ogunwobi OO, Chen T, et al (2014). Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip. Lab Chip, 14, 89-98. crossref(new window)

79.
Sin ML, Gao J, Liao JC, et al (2011). System Integration - A Major Step toward Lab on a Chip. J Biol Eng, 5, 6. crossref(new window)

80.
Smith RJ (1984). Pentagon hit by new microchip troubles. Science, 226, 953.

81.
Stathopoulou A, Gizi A, Perraki M, et al (2003). Real-time quantification of CK-19 mRNA-positive cells in peripheral blood of breast cancer patients using the lightcycler system. Clin Cancer Res, 9, 5145-51.

82.
Stott SL, Hsu CH, Tsukrov DI, et al (2010). Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci U S A, 107, 18392-7. crossref(new window)

83.
Taylor DD, Gercel-Taylor C (2005). Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br J Cancer, 92, 305-11. crossref(new window)

84.
Tian H, Jaquins-Gerstl A, Munro N, et al (2000). Single-strand conformation polymorphism analysis by capillary and microchip electrophoresis: a fast, simple method for detection of common mutations in BRCA1 and BRCA2. Genomics, 63, 25-34. crossref(new window)

85.
Tsujiura M, Ichikawa D, Komatsu S, et al (2010). Circulating microRNAs in plasma of patients with gastric cancers. Br J Cancer, 102, 1174-9. crossref(new window)

86.
Van Loo P, Voet T (2014). Single cell analysis of cancer genomes. Curr Opin Genet Dev, 24, 82-91. crossref(new window)

87.
Vidi PA, Leary JF, Lelievre SA (2013). Building risk-on-achip models to improve breast cancer risk assessment and prevention. Integr Biol, 5, 1110-8. crossref(new window)

88.
Wang C, Ye M, Cheng L, et al (2015). Simultaneous isolation and detection of circulating tumor cells with a microfluidic silicon-nanowire-array integrated with magnetic upconversion nanoprobes. Biomaterials, 54, 55-62. crossref(new window)

89.
Wang J, Chen J, Sen S (2016). MicroRNA as Biomarkers and Diagnostics. J Cell Physiol, 231, 25-30. crossref(new window)

90.
Whitesides GM (2006). The origins and the future of microfluidics. Nature, 442, 368-73. crossref(new window)

91.
Whitesides GM, Ostuni E, Takayama S, et al (2001). Soft lithography in biology and biochemistry. Annu Rev Biomed Eng, 3, 335-73. crossref(new window)

92.
Wu A, Wang L, Jensen E, et al (2010). Modular integration of electronics and microfluidic systems using flexible printed circuit boards. Lab Chip, 10, 519-21. crossref(new window)

93.
Xi L, Nicastri DG, El-Hefnawy T, et al (2007). Optimal markers for real-time quantitative reverse transcription PCR detection of circulating tumor cells from melanoma, breast, colon, esophageal, head and neck, and lung cancers. Clin Chem, 53, 1206-15. crossref(new window)

94.
Yang J, Vykoukal J, Noshari J, et al (2000). Dielectrophoresis-Based Microfluidic Separation and Detection Systems. Int J Adv Manuf Syst, 3, 1-12.

95.
Yang J, Weinberg RA (2008). Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell, 14, 818-29. crossref(new window)

96.
Zhang P, Sun C, Zhang R, et al (2013). A novel and facile microchip based on nitrocellulose membrane toward efficient capture of circulating tumor cells. Se Pu, 31, 518-21 (in Chinese).

97.
Zhang Z, Nagrath S (2013). Microfluidics and cancer: are we there yet? Biomed Microdevices, 15, 595-609. crossref(new window)

98.
Zhao L, Lu YT, Li F, et al (2013). High-purity prostate circulating tumor cell isolation by a polymer nanofiber-embedded microchip for whole exome sequencing. Adv Mater, 25, 2897-902. crossref(new window)

99.
Zheng S, Lin H, Liu JQ, et al (2007). Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells. J Chromatogr A, 1162, 154-61. crossref(new window)