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Lack of Associations between TNF-α Polymorphisms and Cervical Cancer in Thai women
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 Title & Authors
Lack of Associations between TNF-α Polymorphisms and Cervical Cancer in Thai women
Chinchai, Teeraporn; Homchan, Krittaphak; Sopipong, Watanyoo; Chansaenroj, Jira; Swangvaree, Sukumarn; Junyangdikul, Pairoj; Vongpunsawad, Sompong; Poovorawan, Yong;
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 Abstract
The risk of developing cervical cancer in women infected with human papillomavirus (HPV) may be influenced by an individual`s genetic susceptibility. Published data linking single nucleotide polymorphisms (SNPs) in the tumor necrosis factor-alpha (TNF-) promoter region at positions -308G>A (rs1800629) and -238G>A (rs361525) to cervical cancer risk have been inconclusive. In this study, we examined 251 cervical specimens and classified them into two groups according to their cytological findings: 121 cancer cases and 130 controls (low-grade squamous intraepithelial lesion and normal cytology). All specimens were typed by PCR and sequencing for TNF- promoter -308G>A (rs1800629) and -238G>A (rs361525). The genotype distribution of SNPs in either rs1800629 or rs361525 did not significantly demonstrate higher frequency in the cancer group (p
 Keywords
Human papillomavirus;TNF-;sequencing;single nucleotide polymorphism;cervical cancer risk;
 Language
English
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