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Predictive Effect of Preoperative Anemia on Long-Term Survival Outcomes with Non-Muscle Invasive Bladder Cancer
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 Title & Authors
Predictive Effect of Preoperative Anemia on Long-Term Survival Outcomes with Non-Muscle Invasive Bladder Cancer
Celik, Orcun; Akand, Murat; Keskin, Mehmet Zeynel; Ekin, Rahmi Gokhan; Yoldas, Mehmet; Ilbey, Yusuf Ozlem;
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 Abstract
Background: Anemia is the most common hematologic abnormality in bladder cancer (BC) patients. We evaluated the impact of preoperative anemia on oncologic outcomes in BC undergoing transurethral resection of a bladder tumor (TURBT) for the first time diagnosis. Materials and Methods: We retrospectively evaluated the data collected from 639 patients who underwent TURBT between January 2006 and September 2014 in our department. Of these patients, 320 qualified for inclusion in the study. The primary efficacy endpoint was the effect of preoperative anemia status on cancer-specific and overall survival. Independent t-test and chi-square analyses were performed to assess the effects of anemia on oncologic outcomes. Survival was estimated by using the Kaplan-Meier test. Results: There were 118 (36.9%) and 202 (63.1%) patients in the anemia (Group-1) and non-anemia groups (Group-2), respectively. The median follow-up duration was 68 months. Anemia was associated with decreased overall survival (p<0.001). Comparison between cancer-specific survival of two groups did not show any statistically significant difference (p
 Keywords
Urothelial carcinoma;hemoglobin;anemia;survival;bladder;
 Language
English
 Cited by
1.
Prognostic implications of preoperative anemia in urothelial carcinoma: A meta-analysis, PLOS ONE, 2017, 12, 2, e0171701  crossref(new windwow)
2.
Prognostic impact of preoperative anemia on non-muscle-invasive bladder carcinoma treated with GreenLight laser vaporization, Lasers in Medical Science, 2017, 32, 2, 397  crossref(new windwow)
3.
Prognostic value of impaired estimated glomerular filtration rate in intravesical BCG-treated non–muscle-invasive bladder cancer patients, Scientific Reports, 2017, 7, 1  crossref(new windwow)
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