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Evaluation of KiSS1 as a Prognostic Biomarker in North Indian Breast Cancer Cases
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 Title & Authors
Evaluation of KiSS1 as a Prognostic Biomarker in North Indian Breast Cancer Cases
Singh, Richa; Bhatt, Madan Lal Brahma; Singh, Saurabh Pratap; Kumar, Vijay; Goel, Madhu Mati; Mishra, Durga Prasad; Kumar, Rajendra;
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Background: Breast cancer is the commonest female cancer worldwide and its propensity to metastasize negatively impacts on therapeutic outcome. Several clinicopathological parameters with prognostic/predictive significance have been associated with metastatic suppressor expression levels. The role of metastatic suppressor gene (MSG) KiSS1 in breast cancer remains unclear. Our goal was to investigate the possible clinical significance of KiSS1 breast cancer. Materials and Methods: The study was conducted on 87 histologically proven cases of breast cancer and background normal tiisue. Quantitative reverse transcriptase polymerase chain reaction (qRT PCR) and immunohistochemistry (IHC) were used to investigate KiSS1 at gene and protein levels, respectively, for correlation with several patient characteristics including age, family history, hormonal receptor status, stage, tumor size, nodal involvement and metastatic manifestation and finally with median overall survival (OS). Results: Our study revealed (i) KiSS1 levels were generally elevated in breast cancer vs normal tissue (P < 0.05). (ii) however, a statistically significant lower expression of KiSS1 was observed in metastatic vs non metastatic cases (P
Breast cancer;prognosis;KiSS1;North India;metastasis;
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