JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Clinical Significance of Smudge Cells in Peripheral Blood Smears in Hematological Malignancies and Other Diseases
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Clinical Significance of Smudge Cells in Peripheral Blood Smears in Hematological Malignancies and Other Diseases
Chang, Chih-Chun; Sun, Jen-Tang; Liou, Tse-Hsuan; Kuo, Chin-Fu; Bei, Chia-Hao; Lin, Sheng-Jun; Tsai, Wei-Ting; Tan, N-Chi; Liou, Ching-Biau; Su, Ming-Jang; Yen, Tzung-Hai; Chu, Fang-Yeh;
  PDF(new window)
 Abstract
Background: It is reported that the percentage of smudge cells in the blood smear could be a prognostic indicator in chronic lymphocytic leukemia. However, the clinical significance of smudge cells in other hematological malignancies, solid tumors or non-malignant diseases is less clear. Hence, this study was conducted to survey the clinical significance of smudge cells in hematological cancers and other disorders. Materials and Methods: From January to November, 2015, the clinical data of patients who received blood examination with differential counts for clinical purpose and were found to have smudge cells in the peripheral blood film in Far Eastern Memorial Hospital were selected. The percentage of smudge cells and patient outcomes were evaluated for further univariate and survival analyses. Results: A total of 102 patients with smudge cells in their blood smears were included. Smudge cells were frequently presented in out-of-hospital cardiac arrest (OHCA; n
 Keywords
Smudge cells;chronic lymphocytic leukemia;hematological malignancies;cardiac arrest;
 Language
English
 Cited by
 References
1.
Carulli G, Marini A, Baccelli E, et al (2007). Association of B-chronic lymphocytic leukemia and acute myeloid leukemia. J Exp Clin Cancer Res, 26, 421-4.

2.
Go RS (2009). Smudge cells, serum albumin, and prognosis in B-cell chronic lymphocytic leukemia. J Clin Oncol, 27, 44. crossref(new window)

3.
Gogia A, Raina V, Gupta R, et al (2014). Prognostic and predictive significance of smudge cell percentage on routine blood smear in chronic lymphocytic leukemia. Clin Lymphoma Myeloma Leuk, 14, 514-7 crossref(new window)

4.
Gumprecht F (1986). Leucocytenzerfall in blute bal leukemic und bel sohwaren anamlan. Deutches Archlv Kinlache Medicin, 5, 523-48.

5.
Heinivaara O (1959). Smudge cells in lymphocytic leukemia. Ann Med Intern Fenn, 48, 69-75.

6.
Johansson P, Eisele L, Klein-Hitpass L, et al (2010). Percentage of smudge cells determined on routine blood smears is a novel prognostic factor in chronic lymphocytic leukemia. Leuk Res, 34, 892-8. crossref(new window)

7.
Khandelwal A, Seilstad KH, Magro CM (2006). Subclinical chronic lymphocytic leukaemia associated with a 13q deletion presenting initially in the skin: apropos of a case. J Cutan Pathol, 33, 256-9. crossref(new window)

8.
Lunning MA, Zenger VE, Dreyfuss R, et al (2004). Albumin enhanced morphometric image analysis in CLL. Cytometry B Clin Cytom, 57, 7-14.

9.
Macdonald D, Richardson H, Raby A (2003). Practice guidelines on the reporting of smudge cells in the white blood cell differential count. Arch Pathol Lab Med, 127, 105.

10.
Mozaheb Z, Hasanzadeh NazarAbadi MH, Aghaee MA (2012). Chronic lymphocytic leukemia and prognostic factors. Asian Pac J Cancer Prev, 13, 3009-13. crossref(new window)

11.
Nosanchuk JS (1979). The effect of smudge cells on leukocyte counting--are chamber counts necessary? Am J Clin Pathol, 71, 161-6. crossref(new window)

12.
Nowakowski GS, Lee YK, Bone ND, et al (2005). Proteomic analysis of chronic lymphocytic leukemia cells identifies vimentin as a novel prognostic factor for aggressive disease. Blood, 106, 707.

13.
Nowakowski GS, Hoyer JD, Shanafelt TD, et al (2007). Using smudge cells on routine blood smears to predict clinical outcome in chronic lymphocytic leukemia: A universally available prognostic test. Mayo Clin Proc, 82, 449-53.

14.
Nowakowski GS, Hoyer JD, Shanafelt TD, et al (2009). Percentage of smudge cells on routine blood smear predicts survival in chronic lymphocytic leukemia. J Clin Oncol, 27, 1844-9. crossref(new window)

15.
Paydas S (1999). Interesting morphologic finding in T-cell acute lymphoblastic leukemia. Diagn Cytopathol, 21, 55-6. crossref(new window)

16.
Paydas S (2010). Smudge cells: very old history and new conclusions. Leuk Res, 34, 1680. crossref(new window)

17.
Rizzo D, Lotay A, Gachard N, et al (2013). Very low levels of surface CD45 reflect CLL cell fragility, are inversely correlated with trisomy 12 and are associated with increased treatment-free survival. Am J Hematol, 88, 747-53. crossref(new window)

18.
Strati P, Keating MJ, O’Brien SM, et al (2014). Outcomes of first-line treatment for chronic lymphocytic leukemia with 17p deletion. Haematologica, 99, 1350-5. crossref(new window)

19.
Szerafin L, Jakó J, Riskó F, et al (2012). The prognostic value of smudge cells (Gumprecht shadows) in chronic lymphocytic leukaemia. Orv Hetil, 153, 1732-7. crossref(new window)

20.
Trajkova S, Cevreska L, Pivkova-Veljanovska A, et al (2013). Multivariable model consisting of clinical and biological markers for time to first treatment in CLL patients: Preliminary results from single centre experience. Prilozi, 34, 39-48.

21.
Wierda WG, O’Brien S, Wang X, et al (2011). Multivariable model for time to first treatment in patients with chronic lymphocytic leukemia. J Clin Oncol, 29, 4088-95. crossref(new window)

22.
Xu W, Li J, Wu Y, et al (2009). CD38 as a prognostic factor in Chinese patients with chronic lymphocytic leukemia. Leuk Res, 33, 237-43. crossref(new window)

23.
Zaher A, Elgamal B (2011). Peripheral blood smudge cells percentage in de novo CLL: a comparison with other stablished laboratory prognostic markers. Life Sci J, 8, 239-44.