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Frequency and Pattern of Bone Marrow Infiltration in Classical Hodgkin`s Lymphoma: Experience from Southern Pakistan
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 Title & Authors
Frequency and Pattern of Bone Marrow Infiltration in Classical Hodgkin`s Lymphoma: Experience from Southern Pakistan
Sultan, Sadia; Irfan, Syed Mohammed; Parveen, Saira; Haider, Syeda Amna; Masood, Mahira;
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 Abstract
Background: Hodgkin`s lymphoma (formerly, Hodgkins disease) is a potentially curable malignancy with distinctive biological behavior and specific clinical characteristics. Limited information is available from developing countries for patients with classical Hodgkin`s lymphoma (cHL). Therefore we reviewed the demographical and clinico-hematological profiles along with bone marrow infiltration patterns in adult patients presenting at Liaquat National Hospital and Medical College. Materials and Methods: In this cross sectional study, 62 adult () patients with cHL were enrolled from January 2010 to December 2014. Results: The mean age was with a median of 30 years. The male to female ratio was 2:1. B symptoms were present in 72.5% of patients and lymph node enlargement in 85.4%. The frequency of bone marrow infiltration in our cHL patients was found to be 27.4%, the pattern being predominantly focal followed by diffuse. The mean hemoglobin was with a mean MCV of , a mean total leukocyte count of and a mean platelet count of . Conclusions: Our analysis shows that clinico-pathological features of cHL in Pakistan are comparable to published data. Peripheral lymphodenopathy associated with B symptoms is the commonest presentation. Bone marrow involvement is more common in our setup as patients usually presented at an advanced stage of disease.
 Keywords
Hodgkin`s lymphoma;clinico-pathology;bone marrow infiltration;Pakistan;
 Language
English
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