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Role of P57KIP2 Immunohistochemical Expression in Histological Diagnosis of Hydatidiform Moles
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 Title & Authors
Role of P57KIP2 Immunohistochemical Expression in Histological Diagnosis of Hydatidiform Moles
Triratanachat, Surang; Nakaporntham, Pattawan; Tantbirojn, Patou; Shuangshoti, Shanop; Lertkhachonsuk, Ruangsak;
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 Abstract
Purpose: To determine the significance of P57KIP2 immunohistochemistry expression in the histopathological diagnosis of hydatidiform mole. Materials and Methods: Hydatidiform mole patients at King Chulalongkorn Memorial Hospital between January 1999 and December 2011 were recruited. Two gynecologic pathologists reviewed histopathologic slides to confirm diagnosis. Formalin-fixed, paraffin-embedded tissue sections were stained using a bstandard immunostaining system with monoclonal antibodies against P57KIP2 protein. Correlations among pathological features, immunohistochemical expression and clinical data were analyzed. Results: One hundred and twenty-seven hydatidiform mole patients were enrolled. After consensus review, 97 cases were diagnosed as complet (CHM) and 30 cases as partial (PHM). Discordance between the first and final H&E diagnoses was found in 19 cases (14.9%, k
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 Language
English
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 References
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