Advanced SearchSearch Tips
Mean Platelet Volume as an Independent Predictive Marker for Pathologic Complete Response after Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Mean Platelet Volume as an Independent Predictive Marker for Pathologic Complete Response after Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer
Mutlu, Hasan; Eryilmaz, Melek Karakurt; Musri, Fatma Yalccn; Gunduz, Seyda; Salim, Derya Kivrak; Coskun, Hasan Senol;
  PDF(new window)
Background: The impact of mean platelet volume (MPV) on prognosis, diagnosis and response to therapy in cancer patients has been widely investigated. In the present study, we evaluated whether MPV at diagnosis has predictive value for pathologic complete response (pCR) after neoadjuvant chemotherapy in patients with locally advanced breast cancer (LABC). Materials and Methods: A total of 109 patients with LABC from Akdeniz University and Antalya Research and Training Hospital were evaluated retrospectively. Results: ROC curve analysis suggested that the optimum MPV cut-off point for LABC patients with pCR (+) was 8.15 (AUC:0.378, 95%CI [0.256-0.499], p
Mean platelet volume;pathologic complete response;breast cancer;neoadjuvant chemotherapy;
 Cited by
Aliustaoglu M, Bilici A, Seker M, et al (2010). The association of pre-treatment peripheral blood markers with survival in patients with pancreatic cancer. Hepatogastroenterol, 5, 640-45.

Bear HD, Anderson S, Smith RE, et al (2006). Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol, 24, 2019-27. crossref(new window)

Berruti A, Amoroso V, Gallo F, et al (2014). Pathologic complete response as a potential surrogate for the clinical outcome in patients withbreast cancer after neoadjuvant therapy: a meta-regression of 29 randomized prospective studies. J Clin Oncol, 32, 3883-91. crossref(new window)

Buzdar AU, Ibrahim NK, Francis D, et al (2005). Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer. J Clin Oncol, 23, 3676-85. crossref(new window)

Canan A, Halicioglu SS, Gurel S (2012). Mean platelet volume and D-dimer in patients with suspected deep venous thrombosis. J Thromb Thrombolysis, 34, 283-7. crossref(new window)

Colleoni M, Viale G, Zahrieh D, et al (2004). Chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: a study of preoperative treatment. Clin Cancer Res, 10, 6622-8. crossref(new window)

Cristofanilli M, Gonzalez-Angulo A, Sneige N, et al (2005). Invasive lobular carcinoma classic type: response to primary chemotherapy and survival outcomes. J Clin Oncol, 23, 41-8. crossref(new window)

Davi G, Patrono C (2007). Platelet activation and atherothrombosis. NEngl Jmed, 357, 2482-94. crossref(new window)

Dirican A, Kucukzeybek Y, Erten C, et al (2013). Prognostic and predictive value of hematologic parameters in patients with metastatic renal cell carcinoma: second line sunitinib treatment following IFN-alpha. Asian Pac J Cancer Prev, 14, 2101-5. crossref(new window)

Eryilmaz MK, Mutlu H, Salim DK, et al (2014). The neutrophil to lymphocyte ratio has a high negative predictive value for pathologic complete response in locally advanced breast cancer patients receiving neoadjuvant chemotherapy. Asian Pac J Cancer Prev, 15, 7737-40. crossref(new window)

Ferlay J, Soerjomataram I, Dikshit R, et al (2012). Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 136, 359-86.

Gralow JR, Burstein HJ, Wood W , et al (2008). Preoperative therapy in invasive breast cancer: pathologic assessment and systemic therapy issues in operable disease. J Clin Oncol, 26, 814-19. crossref(new window)

Greisenegger S, Endler G, Hsieh K, et al (2004). Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke, 35, 1688-91. crossref(new window)

Guthrie GJ, Charles KA, Roxburgh CS, et al (2013). The systemic inflammation-based neutrophil-lymphocyte ratio: 45 experience in patients with cancer. Crit Rev Oncol Hematol, 88, 218-30. crossref(new window)

Han JS, Park TS, Cho SY, et al (2013). Increased mean platelet volume and mean platelet volume/platelet count ratio in Korean patients with deep vein thrombosis. Platelets, 24, 590-3. crossref(new window)

Inagaki N, Kibata K, Tamaki T, et al (2014). Prognostic impact of the mean platelet volume/platelet count ratio in terms of survival in advanced non-small cell lung cancer. Lung Cancer, 83, 97-101. crossref(new window)

Kim KI, Lee KH, Kim TR, et al (2014). Ki-67 as a predictor of response to neoadjuvant chemotherapy in breast cancer patients. J Breast Cancer, 17, 40-6. crossref(new window)

Kobayashi T, Teruya M, Kishiki T, et al (2008). Inflammation-based prognostic score, prior to neoadjuvant chemoradiotherapy, predicts postoperative outcome in patients with esophageal squamous cell carcinoma. Surgery, 144, 729-35. crossref(new window)

Koh YW, Lee HJ, Ahn JH, et al (2014). Prognostic significance of the ratio of absolute neutrophil to lymphocyte counts for breast cancerpatients with ER/PR-positivity and HER2- negativity in neoadjuvant setting. Tumour Biol, 35, 9823-30. crossref(new window)

Kong X, Moran MS, Zhang N, et al (2011). Meta-analysis confirms achieving pathological complete response after neoadjuvant chemotherapy predicts favourable prognosis for breast cancer patients. Eur J Cancer, 47, 2084-90. crossref(new window)

Krauthamer M, Rouvinov K, Ariad S, et al (2013). A study of inflammation-based predictors of tumor response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Oncol, 85, 27-32. crossref(new window)

Madan SA, John F, Pitchumoni CS (2016). Nonalcoholic Fatty Liver Disease and Mean Platelet Volume: A Systemic Review and Meta-analysis. J Clin Gastroenterol, 50, 69-74. crossref(new window)

Noble F, Hopkins J, Curtis N, et al (2013). The role of systemic inflammatory and nutritional blood-borne markers in predicting response to neoadjuvant chemotherapy and survival in oesophagogastric cancer. Med Oncol, 30, 596. crossref(new window)

Pistelli M, De Lisa M, Ballatore Z, et al (2015). Pre treatment neutrophil to lymphocyte ratio may be a useful tool in predicting survival in early triple negative breast cancer patients. BMC Cancer, 15, 195. crossref(new window)

Sansanayudh N, Anothaisintawee T, Muntham D, et al (2014). Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol, 175, 433-40. crossref(new window)

Tuncel T, Ozgun A, Emirzeoglu L, et al (2014). Mean platelet volume as a prognostic marker in metastatic colorectal cancer patients treated with bevacizumab-combined chemotherapy. Asian Pac J Cancer Prev, 15, 6421-23. crossref(new window)

von Minckwitz G (2013). Neoadjuvant therapy: what are the lessons so far? Hematol Oncol Clin North Am, 27, 767-84. crossref(new window)

Yao M, Liu Y, Jin H, et al (2014). Prognostic value of preoperative inflammatory markers in Chinese patients with breast cancer. Onco Targets Ther, 7, 1743-52.