Advanced SearchSearch Tips
Radiological Downstaging with Neoadjuvant Therapy in Unresectable Gall Bladder Cancer Cases
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Radiological Downstaging with Neoadjuvant Therapy in Unresectable Gall Bladder Cancer Cases
Agrawal, Sushma; Mohan, Lalit; Mourya, Chandan; Neyaz, Zafar; Saxena, Rajan;
  PDF(new window)
Background: Gall bladder cancer (GBC) usually presents as unresectable or metastatic disease. We conducted a feasibility study to evaluate the effect of neoadjuvant therapy (NAT) on radiologic downstaging and resectability in unresectable GBC cases. Materials and Methods: Patients with locally advanced disease were treated with chemoradiotherapy [CTRT] ( external radiotherapy (45Gy) along with weekly concurrent cisplatin and 5-FU 500 mg) and those with positive paraaortic nodes were treated with neoadjuvant chemotherapy [NACT (cisplatin and gemcitabine day 1 and 8, 3 weekly for 3 cycles). Radiological assessment was according to RECIST criteria by evaluating downstaging of liver involvement and lymphadenopathy into complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD). Results: A total of 40 patients were evaluated from January 2012 to December 2014 (CTRT
Radiologic downstaging;neoadjuvant therapy;unresectable gallbladder cancer;
 Cited by
1. ctcaev3.pdf

de Aretxabala X, Roa I, Burgos L, et al (1999). Preoperative chemoradiotherapy in the treatment of gallbladder cancer, Am Surg, 65, 241-6.

3. Ed Cancer Staging Manual Part1.pdf

Gangopadhyay A, Nath P, Biswas J (2015). Reduced dose intensity of chemotherapy may not lead to inferior palliation in locally advanced carcinoma of the gall bladder: An experience from a regional cancer center in Eastern India, J Gastrointest Cancer, 46, 297-300 crossref(new window)

Kato A, Shimizu H, Ohtsuka M, et al (2013). Surgical resection after downsizing chemotherapy for initially unresectable locally advanced biliary tract cancer: a retrospective singlecenter study, Ann Surgical Oncol, 20, 318-24. crossref(new window)

Randi G, Franceschi S, La Vecchia C (2006). Gallbladder cancer worldwide:geographical distribution and risk factors, Int J Cancer, 118, 1591-2. crossref(new window)

Saxena R, Sikora SS, Kaushik SP (1995). A triple bypass procedure for advanced carcinoma of the neck of the gall bladder. Br J Surg, 82, 394-5. crossref(new window)

Sirohi B, Mitra A, Jagannath P, et al (2015). Neoadjuvant chemotherapy in patients with locally advanced gallbladder cancer. Future Oncol, 11, 1501-9. crossref(new window)

Therasse P, Arbuck SG, Eisenhauer EA, Kaplan RS, Rubinstein L (2000). New guidelines to evaluate the response to treatment in Solid Tumors. J Natl Cancer Inst, 9, 205-6.