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Radiological Downstaging with Neoadjuvant Therapy in Unresectable Gall Bladder Cancer Cases
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 Title & Authors
Radiological Downstaging with Neoadjuvant Therapy in Unresectable Gall Bladder Cancer Cases
Agrawal, Sushma; Mohan, Lalit; Mourya, Chandan; Neyaz, Zafar; Saxena, Rajan;
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 Abstract
Background: Gall bladder cancer (GBC) usually presents as unresectable or metastatic disease. We conducted a feasibility study to evaluate the effect of neoadjuvant therapy (NAT) on radiologic downstaging and resectability in unresectable GBC cases. Materials and Methods: Patients with locally advanced disease were treated with chemoradiotherapy [CTRT] ( external radiotherapy (45Gy) along with weekly concurrent cisplatin and 5-FU 500 mg) and those with positive paraaortic nodes were treated with neoadjuvant chemotherapy [NACT (cisplatin and gemcitabine day 1 and 8, 3 weekly for 3 cycles). Radiological assessment was according to RECIST criteria by evaluating downstaging of liver involvement and lymphadenopathy into complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD). Results: A total of 40 patients were evaluated from January 2012 to December 2014 (CTRT
 Keywords
Radiologic downstaging;neoadjuvant therapy;unresectable gallbladder cancer;
 Language
English
 Cited by
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