JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Hepatocellular Carcinoma in a Tertiary Referral Hospital in Indonesia: Lack of Improvement of One-Year Survival Rates between 1998-1999 and 2013-2014
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Hepatocellular Carcinoma in a Tertiary Referral Hospital in Indonesia: Lack of Improvement of One-Year Survival Rates between 1998-1999 and 2013-2014
Loho, Imelda M; Hasan, Irsan; Lesmana, C Rinaldi A; Dewiasty, Esthika; Gani, Rino A;
  PDF(new window)
 Abstract
Background: The survival of hepatocellular carcinoma (HCC) patients is usually low due to late diagnosis. Cipto Mangunkusumo Hospital as the largest tertiary referral hospital in Indonesia, has recently improved its modalities for advanced HCC management, but there has not been any evaluation on any improvement in HCC patient survival. Materials and Methods: A retrospective analysis on 114 HCC patients in 2013-2014 were conducted and compared with the database for 77 HCC patients in 1998-1999. Clinical characteristics and treatment received were recorded and the survival of both groups was analyzed using the Kaplan-Meier method and compared using the log-rank test. Results: The percentage of HBV positive patients had increased after fifteen years from 32.5% to 67.5%. Only two patients (1.8%) in 2013-2014 were diagnosed with HCC during surveillance program. Proportions of Barcelona Clinic Liver Cancer A, B, C, and D in 2013-2014 were 1.8%, 42%, 28.1%, and 28.1%, respectively. There was an increase in the use of potentially curative treatment, such as surgical resection or combination of loco-regional therapies. The one-year survival rate increased from 24.1% in 1998-1999 to 29.4% in 2013-2014, while the median survival decreased from 146 days to 138 days, but the difference was not statistically significant (p
 Keywords
Hepatocellular carcinoma;survival;1998-1999;2013-2104;Indonesia;
 Language
English
 Cited by
 References
1.
NCI Dictionary of Cancer Terms [Online]. National Cancer Institute.

2.
1997. AJCC Cancer Staging Manual, Philadelphia, Lippincott- Raven.

3.
(2012a). EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol, 56, 908-43. crossref(new window)

4.
2012b. [Guidelines on Viral Hepatitis Control], Jakarta, Directorate General of Disease Control and Health Restructuring Ministry of Health, Republic of Indonesia [Article in Indonesian].

5.
Davila JA, Henderson L, Kramer JR, et al (2011). Utilization of surveillance for hepatocellular carcinoma among hepatitis C virus-infected veterans in the United States. Ann Intern Med, 154, 85-93. crossref(new window)

6.
Davila JA, Morgan RO, Richardson PA, et al (2010). Use of surveillance for hepatocellular carcinoma among patients with cirrhosis in the United States. Hepatol, 52, 132-41. crossref(new window)

7.
El-Serag HB, Davila JA, Petersen NJ, et al (2003). The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med, 139, 817-23. crossref(new window)

8.
Hiotis SP, Rahbari NN, Villanueva GA, et al (2012). Hepatitis B vs. hepatitis C infection on viral hepatitis-associated hepatocellular carcinoma. BMC Gastroenterol, 12, 64. crossref(new window)

9.
Hucke F, Sieghart W, Schoniger-Hekele M, et al (2011). Clinical characteristics of patients with hepatocellular carcinoma in Austria - is there a need for a structured screening program? Wien Klin Wochenschr, 123, 542-51. crossref(new window)

10.
Johnson PJ, Berhane S, Kagebayashi C, et al (2015). Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade. J Clin Oncol, 33, 550-8. crossref(new window)

11.
Kudo M (2012). Japan's Successful Model of Nationwide Hepatocellular Carcinoma Surveillance Highlighting the Urgent Need for Global Surveillance. Liver Cancer, 1, 141-3. crossref(new window)

12.
Kuo YH, Lu SN, Chen CL, et al (2010). Hepatocellular carcinoma surveillance and appropriate treatment options improve survival for patients with liver cirrhosis. Eur J Cancer, 46, 744-51. crossref(new window)

13.
Lin CS, Chang CS, Yang SS, et al (2008). Retrospective evaluation of serum markers APRI and AST/ALT for assessing liver fibrosis and cirrhosis in chronic hepatitis B and C patients with hepatocellular carcinoma. Intern Med, 47, 569-75. crossref(new window)

14.
Llovet JM, Bru C, Bruix J (1999). Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis, 19, 329-38. crossref(new window)

15.
Lucas ZDF, Pangan CP, Patal PC, et al (2009). The clinical profile of hepatocellular carcinoma patients at the Philippine General Hospital. Phil J Internal Med, 47, 1-9.

16.
Norsa'adah B, Nurhazalini-Zayani CG (2013). Epidemiology and survival of hepatocellular carcinoma in north-east Peninsular Malaysia. Asian Pac J Cancer Prev, 14, 6955-9. crossref(new window)

17.
Omata M, Lesmana L, Tateishi R, et al (2010). Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma. Hepatol International, 4, 439-74. crossref(new window)

18.
Rosa I, Denis J, Renard P, et al (2010). A French multicentric longitudinal descriptive study of hepatocellular carcinoma management (The Changh Cohort): preliminary results. J Hepatol, 52, S231-2.

19.
Santi V, Buccione D, Di Micoli A, et al (2012). The changing scenario of hepatocellular carcinoma over the last two decades in Italy. J Hepatol, 56, 397-405.

20.
Singal AG, Volk ML, Rakoski MO, et al (2011). Patient involvement in healthcare is associated with higher rates of surveillance for hepatocellular carcinoma. J Clin Gastroenterol, 45, 727-32. crossref(new window)

21.
Singal AG, Yopp A, C SS, et al (2012). Utilization of hepatocellular carcinoma surveillance among American patients: a systematic review. J Gen Intern Med, 27, 861-7. crossref(new window)

22.
Sithinamsuwan P, Piratvisuth T, Tanomkiat W, et al (2000). Review of 336 patients with hepatocellular carcinoma at Songklanagarind Hospital. World J Gastroenterol, 6, 339-43. crossref(new window)

23.
Somboon K, Siramolpiwat S, Vilaichone RK (2014). Epidemiology and survival of hepatocellular carcinoma in the central region of Thailand. Asian Pac J Cancer Prev, 15, 3567-70. crossref(new window)

24.
Sulaiman HA, Julitasari, Sie A, et al (1995). Prevalence of hepatitis B and C viruses in healthy Indonesian blood donors. Trans R Soc Trop Med Hyg, 89, 167-70. crossref(new window)