Development of Gastric Retentive Bi-layered Tablet using Floating Drug Delivery System

Title & Authors
Development of Gastric Retentive Bi-layered Tablet using Floating Drug Delivery System
Park, Jun-Bom;

Abstract
The aim of this study was to develop gastric retentive bi-layered tablet using floating drug delivery technique. Metformin was selected as a model drug due to its narrow absorption window as well as very highly water solubility. These properties of metformin led to be difficult controlling the drug release. The bi-layered tablet was prepared with bi-layered compression machine to minimize interference between floating part and controlling part. The tablet weight, appearance and hardness were evaluated after compression process. The times of 'time to floating' and 'Floating duration' were tested for floating ability and drug release study was also carried out to understand drug release behavior. Furthermore, the drug release of bi-layered tablet was compared with marketed metformin tablet with sustained release pattern (Glucopharge XR$\small{^{(R)}}$).The floating ability and drug release behaviors were well controlled by changing amounts of $\small{NaHCO_3}$ (floating substance) and hydroxypropyl methylcellulose (HPMC; release control material). Bi-layered tablet had 13s of time to float, over 10h of floating duration and very similar drug release behavior compared with Glucopharge XR$\small{^{(R)}}$($\small{f_2}$: 89.6). Consequently, the bi-layered tablet with floating ability was successfully prepared and these properties can maximize the efficacy of metformin.
Keywords
Bi-layer tablet;Floating Delivery;Gastric retentive;HPMC;Metformin;
Language
Korean
Cited by
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