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Development of Scar Improving Materials using Enkephalin Derivatives
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 Title & Authors
Development of Scar Improving Materials using Enkephalin Derivatives
Kim, Yang Woo; Kim, Hyoung Shik; Kim, Soo-Yun; Choi, Yun-Hee; Moh, Sang Hyun; Cheon, Young Woo;
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Although demand for scar treatment has been rising as our quality of life is improved, most scar treatment products rely on importation. Enkephalin is one of the neuropeptides secreted from neuronal ends. As both skin and neuron are derived from the exoderm during the development process, skin cells express opioid receptors as neuronal cells do. Opioid receptors are categorized into three types, mu(m)-, delta(d)-, and kappa(k)- opioid receptors, all of which are directly involved in the wound healing process. In this study, enkephalin derivatives are synthesized by Alanin Scan and their efficacy was evaluated and compared. In vitro wound healing effects, stimulatory effects of collagen synthesis, and skin hydration effects were also evaluated and confirmed. Among Enkephalin derivatives, AS13 showed highest wound healing effect.
Enkephalin;Neuropeptide;Delta-opioid receptor;Scar;
 Cited by
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