Advanced SearchSearch Tips
Development of Scar Improving Materials using Enkephalin Derivatives
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Development of Scar Improving Materials using Enkephalin Derivatives
Kim, Yang Woo; Kim, Hyoung Shik; Kim, Soo-Yun; Choi, Yun-Hee; Moh, Sang Hyun; Cheon, Young Woo;
  PDF(new window)
Although demand for scar treatment has been rising as our quality of life is improved, most scar treatment products rely on importation. Enkephalin is one of the neuropeptides secreted from neuronal ends. As both skin and neuron are derived from the exoderm during the development process, skin cells express opioid receptors as neuronal cells do. Opioid receptors are categorized into three types, mu(m)-, delta(d)-, and kappa(k)- opioid receptors, all of which are directly involved in the wound healing process. In this study, enkephalin derivatives are synthesized by Alanin Scan and their efficacy was evaluated and compared. In vitro wound healing effects, stimulatory effects of collagen synthesis, and skin hydration effects were also evaluated and confirmed. Among Enkephalin derivatives, AS13 showed highest wound healing effect.
Enkephalin;Neuropeptide;Delta-opioid receptor;Scar;
 Cited by
최적의 luminescence 신호 분석을 위한 유전자 전달 방법의 비교연구,박서현;이승호;

한국산학기술학회논문지, 2016. vol.17. 11, pp.640-647 crossref(new window)
Bello, Y.M. and T.J. Phillips, Recent advances in wound healing. JAMA, 283(6), pp.716-718, 2000. DOI: crossref(new window)

Midwood, K.S., L.V. Williams, J.E. Schwarzbauer, Tissue repair and the dynamics of the extracellular matrix. Int J Biochem Cell Biol, 36(6), pp.1031-1037, 2004. DOI: crossref(new window)

Stadelmann, W.K., A.G. Digenis, G.R. Tobin, Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg, 176, pp.26-38, 1998. DOI: crossref(new window)

Rosenberg L., de la Torre J. Wound EHaling, Growth Factors, 2006.

Bigliardi-Qi, M., Gaveriaux-Ruff, C., Zhou, H., Hell, C., Bady, P., Rufli, T., Kieffer, B. and Bigliardi, P., Deletion of delta-opioid receptor in mice alters skin differentiation and delays wound healing. Differentiation, 74, pp.174-185, 2006. DOI: crossref(new window)

Bigliardi, P.L., Neumann, C., Teo, Y.L., Pant, A. and Bigliardi-Qi, M., Activation of the delta-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration. Br J Pharmacol, 2014

Tominaga, M., Ogawa, H. and Takamori, K., Possible roles of epidermal opioid systems in pruritus of atopic dermatitis. J Invest Dermatol, 127, pp.2228-2235, 2007. DOI: crossref(new window)

Bigliardi-Qi, M., Bigliardi, P.L., Buchner, S. and Rufli, T., Characterization of mu-opiate receptor in human epidermis and keratinocytes. Ann N Y Acad Sci., 885, pp.368-371, 1999. DOI: crossref(new window)

Martens, G.J. and Herbert, E., Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis. Nature, 310, pp.251-254, 1984. DOI: crossref(new window)

Slominski, A.T., Zmijewski, M.A., Zbytek, B., Brozyna, A.A., Granese, J., Pisarchik, A., Szczesniewski, A., Tobin, D.J., Regulated proenkephalin expression in human skin and cultured skin cells. J Invest Dermatol, 131, pp.613-622, 2011. DOI: crossref(new window)

Haase, I., Evans, R., Pofahl, R. Watt, F.M., Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways. J Cell Sci, 116, pp.3227-3238, 2003. DOI: crossref(new window)