Advanced SearchSearch Tips
Development of Anti-Wrinkle Materials using Galloyl-Peptide Derivatives
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Development of Anti-Wrinkle Materials using Galloyl-Peptide Derivatives
Jung, Hae Soo; Song, Mi Young; Kim, Hyoung Sik; Seo, Hyo Hyun; Lee, Jeong Hun; Lee, Kyung Rok; Hong, Il; Moh, Sang Hyun;
  PDF(new window)
Conjugating a phytochemical, a strong antioxidant, with a functional peptide not only compensates for its stability, but also improves its solubility and anti-wrinkle effects, thereby contributing to the possibility of becoming an excellent cosmetic ingredient. Thus, in this study we examined the potential cosmetic use of a phytochemical-peptide derivative using gallic acid, a phytochemical with antioxidant, anti-inflammatory, and anti-cancer effects. To evaluate the antioxidant and wrinkle-improving efficacy of 5 synthesized gallic acids conjugated with LVH, IVH, KTTKS, YGGFM, and YGGFLRKYP respectively, we observed the expression of genes related to wrinkle improvement using DPPH radical scavenging activity and real-time PCR. As a result, all 5 derivatives had excellent free radical scavenging effects. The expression level of genes involved collagen synthesis also increased, and the secreted peptides during collagen production contributed to their antioxidant and wrinkle improving effects. These results mark the potential use of gallic acid peptide derivatives as a cosmetic ingredient for anti-oxidation and wrinkle improvement.
Phytochemical;Gallic acid;Galloyl derivatives;Anti-Oxidant effect;Anti-Wrinkle effect;
 Cited by
Stability of Various Liposome Formulation Containing the Phytochemical-Peptide Derivatives, Journal of the Society of Cosmetic Scientists of Korea, 2016, 42, 2, 135  crossref(new windwow)
Kasture VS, Sahu RK, Anjan K, Musmade DS, "Synthesis and antiparkinson activity of Gallic acid derivatives" Medicinal Chemistry and Drug Discovery, 3(2), pp. 134-139, 2012.

Reynolds LD, Wilson NG "Scribes and Scholars" 3rd edition, Oxford University Press, pp. 193-194, 1991.

Nguyen DM, Seo DJ, Lee HB, Kim IS, Kim KY, Park RD, Jung WJ, "Antifungal activity of gallic acid purified from Terminalia nigrovenulosa bark against Fusarium solani." Microb Pathog 56, pp. 8-15, 2013. DOI: crossref(new window)

Choi HJ, Song JH, Park KS, Baek SH, "In vitro anti-enterovirus 71 activity of gallic acid from Woodfordia fruticosa flowers." Lett Appl Microbiol 50, pp. 438-440, 2010. DOI: crossref(new window)

Liu Z, Ma LP, Zhou B, Yang L, Liu ZL, "Antioxidative effects of green tea polyphenols on free radical initiated and photosensitized peroxidation of human low density lipoprotein." Chem Phys Lipids, 106(1), pp. 53-63, 2000. DOI: crossref(new window)

Paolo R, "Peptides and Peptidomimetics in Medicinal Chemistry", Medicinal Chemistry and Drug Design, 8, pp. 978-953, 2012.

Hashimoto SI, Kyowa C, Hofu S, "Ribosome-independent Peptide Synthesis in Nature and Their Application to Dipeptide Production", J. Biol. Macromol, 8(2), pp. 28-37, 2008.

Ioannis, S., F. Demosthenes, V. Katerina, G. T. Andreas, K. Valentinos, B. Evangelos "Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs." Mar. Drugs, 8, pp. 629-657, 2010. DOI: crossref(new window)

Ruiz, M. A., B. Clares, M. E. Morales, and V. Gallardo, "Evaluation of the anti-wrinkle efficacy of cosmetic formulations with an anti-aging peptide." Ars. Pharm. 50, pp. 168-176, 2010.

Robinson, L. R., N. C. Fitzgerald, D. G. Doughty, N. C. Dawes, C. A. Berge, D. L. Bissett, "Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin." J. Cosmetic science 27, pp. 155-160, 2005. DOI: crossref(new window)

van Meerloo J1, Kaspers GJ, Cloos J, "Cell sensitivity assays: the MTT assay" Methods Mol Biol. 731, pp. 237-245, 2011. DOI: crossref(new window)

Fotakis G, Timbrell JA, "In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride." Toxicol Lett. 160, pp. 171-177, 2006. DOI: crossref(new window)

Huang D, Ou B, Prior RL, "The chemistry behind antioxidant capacity assays." J Agric Food Chem. 53(6), pp. 1841-1856, 2005. DOI: crossref(new window)

Imai J, Ide N, Nagae S, Moriguchi T, Matsuura H, Itakura Y, "Antioxidant and radical scavenging effects of aged garlic extract and its constituents." Planta Med., 60(5), 417-420, 1994. DOI: crossref(new window)

Takagi M, Nishioka M, Kakihara H, Kitabayashi M, Inoue H, Kawakami B, Oka M, Imanaka T, "Characterization of DNA polymerase from Pyrococcus sp. strain KOD1 and its application to PCR." Appl Environ Microbiol. 63(11), 4504-4510, 1997.

Hashimoto H, Nishioka M, Fujiwara S, Takagi M, Imanaka T, Inoue T, Kai Y, "Crystal structure of DNA polymerase from hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1." J Mol Biol. 306(3), 469-477, 2001. DOI: crossref(new window)

Atsushi Masamune, Shin Hamada, Kazuhiro Kikuta, Tetsuya Takikawa, Shin Miura, Eriko Nakano, Tooru Shimosegawa. "The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice" Journal of Gastroenterology. 48, pp. 602-609, 2013. DOI: crossref(new window)

Cho S, Kim HH, Lee MJ, Lee S, Park CS, Nam SJ, Han JJ, Kim JW, Chung JH, "Phosphatidylserine prevents UV-induced decrease of type I procollagen and increase of MMP-1 in dermal fibroblasts and human skin in vivo" J Lipid Res. 49, pp. 1235-1245, 2008. DOI: crossref(new window)