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Development of Anti-Wrinkle Materials using Galloyl-Peptide Derivatives
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 Title & Authors
Development of Anti-Wrinkle Materials using Galloyl-Peptide Derivatives
Jung, Hae Soo; Song, Mi Young; Kim, Hyoung Sik; Seo, Hyo Hyun; Lee, Jeong Hun; Lee, Kyung Rok; Hong, Il; Moh, Sang Hyun;
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Conjugating a phytochemical, a strong antioxidant, with a functional peptide not only compensates for its stability, but also improves its solubility and anti-wrinkle effects, thereby contributing to the possibility of becoming an excellent cosmetic ingredient. Thus, in this study we examined the potential cosmetic use of a phytochemical-peptide derivative using gallic acid, a phytochemical with antioxidant, anti-inflammatory, and anti-cancer effects. To evaluate the antioxidant and wrinkle-improving efficacy of 5 synthesized gallic acids conjugated with LVH, IVH, KTTKS, YGGFM, and YGGFLRKYP respectively, we observed the expression of genes related to wrinkle improvement using DPPH radical scavenging activity and real-time PCR. As a result, all 5 derivatives had excellent free radical scavenging effects. The expression level of genes involved collagen synthesis also increased, and the secreted peptides during collagen production contributed to their antioxidant and wrinkle improving effects. These results mark the potential use of gallic acid peptide derivatives as a cosmetic ingredient for anti-oxidation and wrinkle improvement.
Phytochemical;Gallic acid;Galloyl derivatives;Anti-Oxidant effect;Anti-Wrinkle effect;
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파이토케미컬 펩타이드 유도체를 포함하는 다양한 리포좀 제형의 안정성,한병석;김수영;이경록;서효현;모상현;

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