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Study on the degradation rate and pH change of PLGA membrane with a biodegradation
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 Title & Authors
Study on the degradation rate and pH change of PLGA membrane with a biodegradation
Xie, Yuying; Park, Jong-Soon; Kang, Soon-Kook;
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Medical polymer PLGA is biocompatible, biodegradation, mechanical characteristic and biostability, and the degradation time can be adjust by controlling the number of monomer. In this paper, PLGA membranes have different composition ratio by L/D type was prepared by phase transition method. And the PLGA membrane in phosphate buffered saline(PBS) at the different test temperatures for different periods of time to examined for change in mass and measured the pH of degradation media. Measurement of Tg and surface structure was performed using a DSC and Stereoscopic microscope. As the molecular weighter increase, hydrolysis rate was decrease in geometrical progression. According to the composition ratio by L/D type, degradation rate and the change of pH are large.
Activation energy;biodegradation;Glass transtion temperature;PLGA membrane;Phase transition method;
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