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Cell proliferation inhibition effects of epigallocatechin-3-gallate in TREK2-channel overexpressing cell line
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 Title & Authors
Cell proliferation inhibition effects of epigallocatechin-3-gallate in TREK2-channel overexpressing cell line
Kim, Yangmi; Kim, Kyung-Ah;
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Two-pore domain potassium (K2P) channels are the targets of physiological stimuli, such as intracellular pH, bioactive lipids, and neurotransmitters, and they set the resting membrane potential. Some types of K2P channels play a critical role in both apoptosis and tumoriogenesis. Among the K2P channels, no antagonists of the TREK2 channel have been reported. The aim of the present study was to determine if the TREK2 channel is blocked and whether cell proliferation is influenced by flavonoids in the TREK2 overexpressing HEK293 cells (HEKT2). The electrophysiological current was recorded using single channel patch clamp techniques and cell proliferation was measured using a XTT assay. The electrophysiological results showed that the TREK2 channel activity was reduced to (n
Epigallocatechin-3-gallate(EGCG);Flavonoid;Quercetin;TREK2;Two-pore domain potassium(K2P) channels;
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