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Effects of Dietary DFA IV on Lumen Short Chain Fatty Acids Production and Intestinal Environment in Rats
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 Title & Authors
Effects of Dietary DFA IV on Lumen Short Chain Fatty Acids Production and Intestinal Environment in Rats
Hong, Kyung Hee; Jang, Ki-Hyo; Kang, Soon Ah;
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This study examined the improving effect of DFA IV obtained from bacterial fermentation on the gut health. The effects of the dietary DFA IV on the intestinal mass, short chain fatty acids production and pH were evaluated in vivo. Sprague-Dawley rats were fed the 0% (control) or 1% DFA IV supplemented diets for 3 weeks. Supplementation of DFA IV resulted in a significant increase in cecal tissue and wall weights. Together with the lowering of the cecal and colonic pH, the amount of acetate and butyrate increased by 1.6 and 3.2 fold of the control group in the cecum, respectively, in the rats fed DFA IV diets. The DFA IV diet also significantly increased the cecal lactate 1.5 fold compared to the control diet, indicating that dietary DFA IV stimulated the growth of lactic acid bacteria and bifidobacteria in the intestine. Based on the above results, it is concluded that the dietary DFA IV may be used as a putative prebiotic supplement.
DFA IV;Shot chain fatty acids;Intestinal environment;Rat;
 Cited by
R. Jha. J. D. Berrocoso, "Review: Dietary fiber utilization and its effects on physiological functions and gut health of swine", Animal, 9(9), pp. 1441-1452, 2015. crossref(new window)

K. Saito, F. Tomita, "Difructose anhydrides: their mass-production and physiological functions", Biosci Biotechnol Biochem, 64(7), pp. 1321-1327, 2000. crossref(new window)

K. B. Song, K. S. Bae, Y.B. Lee, K. Y. Lee, S. K. Rhee, "Characteristics of levan fructotransferase from Arthrobacter ureafaciens K2032 and difructose anhydride IV formation from levan", Enzyme Microb Technol, 27, pp. 212-218, 2000. crossref(new window)

C. W. Lee, L. M. Lee, H. M. Kim, W. K. Yoon, S. H. Kim, H. Y. Son, H. C. Kim, "Single and four-week oral toxicity studies of difructose dianhydride (DFA IV) in Sprague-Dawley rats", J Toxicol Pub Health, 20, pp. 263-272, 2004.

K. Minamida, K. Shiga, I. N. Sujaya, T. Sone, A. Yokota, H. Hara, K. Asano, F. Tomita, "Effects of difructose anhydride III (DFA III) administration on rat intestinal microbiota", J Biosci Bioeng, 99(3), pp. 230-236, 2005 crossref(new window)

J. M. Wong, R. de Souza, C. W. Kendall, A. Emam, D. J. Jenkins, "Colonic health: fermentation and short chain fatty acids", J Clin Gastroenterol, 40(3), pp. 235-243, 2006. crossref(new window)

S. I. Cook, J. H. Sellin, "Short chain fatty acids in health and disease", Aliment Pharmacol Ther, 12(6), pp. 499-507, 1998. crossref(new window)

E. Hijova, A. Chmelarova, "Short chain fatty acids and colonic health", Bratisl Lek Listy, 108(8), pp. 354-358, 2007.

K. H. Jang, S. A. Kang, Y. H. Cho, Y. Y. Kim, Y. J. Lee, K. H. Hong, E. K. Jang, C. H. Kim, R. W. Choue, "The effects of levan and inulin on the growth of lactic acid-producing bacteria and intestinal conditions in rats", Kor J Nutr, 35, pp. 912-918, 2002.

K. Saito, T. Hira, T. Suzuki, H. Hara, A. Yokota, F. Tomita, "Effects of DFA IV in rats: calcium absorption and metabolism of DFA IV by intestinal microorganisms", Biosci Biotechnol Biochem, 63(4), pp. 655-561, 1999. crossref(new window)

H. Hara, S. Onoshima, C. Nakagawa, "Difructose anhydride III promotes iron absorption in the rat large intestine", Nutrition, 26(1), pp. 120-127, 2010. crossref(new window)

A. Tamura, Y. Mita, N. Shigematsu, H. Hara, N. Nishimura, "Different effects of difructose anhydride III and inulin-type fructans on cecal microbiota in rats", Arch Anim Nutr, 60(5), pp. 358-364, 2006. crossref(new window)

A. R. Lobo, J. M. Filho, E. P. Alvares, M. L. Slocato, C. Colli, "Effects of dietary lipid composition and inulin-type fructans on mineral bioavailability in growing rats", Nutrition, 25(2), pp. 216-225, 2009. crossref(new window)

M. J. Peinado, A. Echavarri, R. Ruiz, E. Suarez-Pereira, C. Ortiz Mellet, J. M. Garcia Fernandez, L. A. Rubio, "Effects of inulin and di-D-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens", Animal, 7(11), pp. 1779-1788, 2013. crossref(new window)

J. M. Campbell, G. C. Fahey Jr, B. W. Wolf, "Selected indigestible oligosaccharides affect large bowel mass, cecal and fecal short-chain fatty acids, pH and microflora in rats", J Nutr, 127(1) pp. 130-136, 1997. crossref(new window)

G. Jakobsdottir, C. Jadert, L. Holm, M. E. Nyman, "Propionic and butyric acids, formed in the caecum of rats fed highly fermentable dietary fibre, are reflected in portal and aortic serum", Br J Nutr, 110(9), pp. 1565-1572, 2013. crossref(new window)

B. O. Lim, C. J. Lee, J. D. Kim, "Study on immunoregulatory function of dietary fiber", Food Ind Nutr, 9. pp. 26-30, 2004.

K. Afsana, K. Shiga, S. Ishizuka, H. Hara, "Ingestion of an indigestible saccharide, difructose anhydride III, partially prevents the tannic acid-induced suppression of iron absorption in rats", J Nutr, 133(11), pp. 3553-3560, 2003. crossref(new window)

D. J. Jenkins, T. M. Wolever, A. Jenkins, F. Brighenti, V. Vuksan, A. V. Rao, S. C. Cunnane, A. Ocana, P. Corey, C. Vezina, "Specific types of colonic fermentation may raise low-density-lipoprotein-cholesterol concentrations", Am J Clin Nutr, 54(1), pp. 141-147 1991. crossref(new window)

A. Hague, D. J. Elder, D. J. Hicks, C. Paraskeva, "Apoptosis in colorectal tumour cells: induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate", Int J Cancer, 60(3), pp. 400-406, 1995. crossref(new window)

K. E. Scholz-Ahrens, G. Schaafsma, E. G. van den Heuvel, J. Schrezenmeir, "Effects of prebiotics on mineral metabolism" Am J Clin Nutr 73(2 Suppl), pp. 459S-464S, 2001. crossref(new window)

S. Macfarlane, G. T. Macfarlane, "Regulation of short-chain fatty acid production", Proc Nutr Soc, 62(1), pp. 67-72, 2003. crossref(new window)

G. R. Gibson, M. B. Roberfroid, "Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics", J Nutr, 25(6), pp. 1401-1412, 1995.

K. Kimura, A. L. McCartney, M. A. McConnell, G. W. Tannock, "Analysis of fecal populations of bifidobacteria and lactobacilli and investigation of the immunological responses of their human hosts to the predominant strains", Appl Environ Microbiol, 63(9), pp. 3394-3398, 1997.

J. M. Campbell, G. C. Fahey Jr, B. W. Wolf, "Selected indigestible oligosaccharides affect large bowel mass, cecal and fecal short-chain fatty acids, pH and microflora in rats", J Nutr, 127(1), pp. 130-136, 1997. crossref(new window)

H. J. Flint, "The impact of nutrition on the human microbiome", Nutr Rev, 70 Suppl 1, pp. S10-13, 2012. crossref(new window)

G. Le Blay, C. Michel, H. M. Blottiere, C. Cherbut, "Prolonged intake of fructo-oligosaccharides induces a short-term elevation of lactic acid-producing bacteria and a persistent increase in cecal butyrate in rats", J Nutr, 129(12), pp. 2231-2235, 1999. crossref(new window)

D. J. Kim, M. J. Han, "Inhibition of intestinal bacterial enzyme by lactic acid bacteria", Yakhak Hoeji, 38, pp. 169-174, 1995.

M. Teramura, S. Wynn, M. Reshalaitihan, W. Kyuno, T. Sato, M. Ohtani, C. Kawashima, M. Hanada, "Supplementation with difructose anhydride III promotes passive calcium absorption in the small intestine immediately after calving in dairy cows", J Dairy Sci, 98(12), pp. 8688-8697, 2015. crossref(new window)

G. Schaafsma, J. L. Slavin, "Significance of inulin fructans in the human diet", Comprehensive Reviews in the Food Science and Food safety, 14, pp. 37-47, 2015. crossref(new window)

H. D. Hoscher, J. L. Doligale, L. L. Bauer, V. Gourineni, C. L. Pelkman, G. C. Fahey, K. S. Swanson, "Gastrointestinal tolerance and utilization of agave inulin by healthy adults", Food Funct, 5, pp. 1142-1149, 2014. crossref(new window)

D. J. Chae, K. H. Jang, "Development of the sourdough Manju production with cake flour and mixed probiotics", Journal of the Korea Academia-Industrial Cooperation Society, 15(9), pp. 5693-5699, 2014. DOI: crossref(new window)

K. H. Hong, H. S. Kim, K. H. Jang, S. A. Kang, "The improvement effects of beta-glucan on adiposity and serum lipids levels in high fat diet-induced obse rats", Journal of the Korea Academia-Industrial Cooperation Society, 16(6), pp. 3973-3981, 2015. crossref(new window)

M. J. Kim, Y. G. Kim, H. S. Kim, C. Cheong, K. H. Jang, S. A. Kang, "Effects of antioxidant activities in ethanol extract of apple peel, grape peel, and sweet potato as natural antioxidant", Journal of the Korea Academia-Industrial Cooperation Society, 15(6), pp. 3766-3773, 2014. DOI: crossref(new window)