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Antimicrobial resistance rates changes according to the amount of the antimicrobial agent in clinically important strain isolated from blood cultures
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 Title & Authors
Antimicrobial resistance rates changes according to the amount of the antimicrobial agent in clinically important strain isolated from blood cultures
Kim, Jae-Jung;
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The purpose of the study is to investigate the correlation between the amount of antimicrobial agent (Defined Daily Dose, DDD) and antimicrobial resistance rate (%). The treatment of infectious diseases is becoming increasingly difficult, due to the increase in the number of multi-drug resistant bacteria, making it a clinically significant problem. Among the various factors, antimicrobial abuse is a major cause of antimicrobial resistance. The study was conducted on inpatients in a secondary university hospital in the central region utilizing the hospital`s computerized statistical data and microbiological program of laboratory medicine from January 2010 to December 2014 pertaining to the dose of antimicrobial drugs for Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli strains isolated from blood culture. We analyzed the antimicrobial resistance rate per dose with the Pearson correlation coefficient. A significant (positive?) correlation was detected between the cefepime dose and the resistance of E. coli (P<0.033; r
Antimicrobial Drug resistance;Antimicrobial agents;Acinetobacter baumannii;Defined Daily Dose;Escherichia coli;
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