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Allium hookeri Extract Improves Type 2 Diabetes Mellitus in C57BL/KSJ Db/db Obese Mouse via Regulation of Hepatic Lipogenesis and Glucose Metabolism
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  • Journal title : Journal of Life Science
  • Volume 25, Issue 10,  2015, pp.1081-1090
  • Publisher : Korean Society of Life Science
  • DOI : 10.5352/JLS.2015.25.10.1081
 Title & Authors
Allium hookeri Extract Improves Type 2 Diabetes Mellitus in C57BL/KSJ Db/db Obese Mouse via Regulation of Hepatic Lipogenesis and Glucose Metabolism
Kim, Ji-Soo; Heo, Jin-Sun; Choi, Jong-Won; Kim, Gun-Do; Sohn, Kie-Ho;
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 Abstract
Diabetes has been one of major health risks in industrialized countries. Allium hookeri is a wild herb distributed in India and Myanmar. The root of the plant has been used as food and medicine in Southeast Asia. We investigated Allium hookeri extract improves type 2 diabetes mellitus in C57BL/KSJ db/db obese mouse. C57BL/KSJ db/db obese mouse arise out of Type 2 diabetes and we treated Allium hookeri methanol extract 400 mg/kg (AH 400), 800 mg/kg (AH 800), positive control group (thiazolidinedine;TZDs) were administered orally for 8weeks. AH treated group normalized lipid enzyme system (triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol) and serum glucose, HbA1c and plasma insulin level. AH treated group recovered β-cell damage by hyperglycemia and fatty liver disease. AH treated group significantly up regulated expression of Peroxisome proliferator-activated receptor gamma (PPAR-γ), pyruvate dehydrogenase kinase4 (PDK4), Sterol regulatory element-binding protein 1c (SREBP 1) and fork head box O1 (FOX 01) proteins in C57BL/KSJ db/db obese mouse liver. And we found that AH treated group decreased hepatic malondialdehyde formation in C57BL/KSJ db/db obese mouse liver. These results indicate that Allium hookeri methanol extract might be a potential anti-diabetic agent and could be useful in the treatment of type 2 diabetes mellitus.
 Keywords
Allium hookeri;insulin;proliferator-activated receptor γ(PPARγ);type 2 diabetes mellitus;TZDs (thiazolidinedine);
 Language
Korean
 Cited by
1.
Effect of Allium hookeri Root on Plasma Blood Glucose and Fat Profile Levels in Streptozotocin-Induced Diabetic Rats, Journal of the East Asian Society of Dietary Life, 2016, 26, 6, 481  crossref(new windwow)
2.
Effects of Dietary Supplementation with Allium hookeri Root on Hepatic Enzyme Contents in Streptozotocin-induced Diabetic Rats, Journal of the East Asian Society of Dietary Life, 2017, 27, 4, 399  crossref(new windwow)
3.
The Hypolipidemic Effect of Allium Hookeri in Rats Fed with a High Fat Diet, The Korean Journal of Community Living Science, 2016, 27, 1, 137  crossref(new windwow)