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Allium hookeri Extract Improves Type 2 Diabetes Mellitus in C57BL/KSJ Db/db Obese Mouse via Regulation of Hepatic Lipogenesis and Glucose Metabolism
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  • Journal title : Journal of Life Science
  • Volume 25, Issue 10,  2015, pp.1081-1090
  • Publisher : Korean Society of Life Science
  • DOI : 10.5352/JLS.2015.25.10.1081
 Title & Authors
Allium hookeri Extract Improves Type 2 Diabetes Mellitus in C57BL/KSJ Db/db Obese Mouse via Regulation of Hepatic Lipogenesis and Glucose Metabolism
Kim, Ji-Soo; Heo, Jin-Sun; Choi, Jong-Won; Kim, Gun-Do; Sohn, Kie-Ho;
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 Abstract
Diabetes has been one of major health risks in industrialized countries. Allium hookeri is a wild herb distributed in India and Myanmar. The root of the plant has been used as food and medicine in Southeast Asia. We investigated Allium hookeri extract improves type 2 diabetes mellitus in C57BL/KSJ db/db obese mouse. C57BL/KSJ db/db obese mouse arise out of Type 2 diabetes and we treated Allium hookeri methanol extract 400 mg/kg (AH 400), 800 mg/kg (AH 800), positive control group (thiazolidinedine;TZDs) were administered orally for 8weeks. AH treated group normalized lipid enzyme system (triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol) and serum glucose, HbA1c and plasma insulin level. AH treated group recovered β-cell damage by hyperglycemia and fatty liver disease. AH treated group significantly up regulated expression of Peroxisome proliferator-activated receptor gamma (PPAR-γ), pyruvate dehydrogenase kinase4 (PDK4), Sterol regulatory element-binding protein 1c (SREBP 1) and fork head box O1 (FOX 01) proteins in C57BL/KSJ db/db obese mouse liver. And we found that AH treated group decreased hepatic malondialdehyde formation in C57BL/KSJ db/db obese mouse liver. These results indicate that Allium hookeri methanol extract might be a potential anti-diabetic agent and could be useful in the treatment of type 2 diabetes mellitus.
 Keywords
Allium hookeri;insulin;proliferator-activated receptor γ(PPARγ);type 2 diabetes mellitus;TZDs (thiazolidinedine);
 Language
Korean
 Cited by
1.
The Hypolipidemic Effect of Allium Hookeri in Rats Fed with a High Fat Diet, The Korean Journal of Community Living Science, 2016, 27, 1, 137  crossref(new windwow)