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The Effects of Aerobic Exercise Training on Blood Lipid Profiles, Fibrinolytic Activities, and Nitric Oxide Levels in High-fat-diet induced Rats
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  • Journal title : Journal of Life Science
  • Volume 25, Issue 12,  2015, pp.1432-1438
  • Publisher : Korean Society of Life Science
  • DOI : 10.5352/JLS.2015.25.12.1432
 Title & Authors
The Effects of Aerobic Exercise Training on Blood Lipid Profiles, Fibrinolytic Activities, and Nitric Oxide Levels in High-fat-diet induced Rats
Son, Won-Mok; Kim, Do-Yeon; Sung, Ki-Dong; Kwak, Yi-Sub; Baek, Yeong-Ho; Park, Song-Young;
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Although exercise training has been utilized to improve vascular function in animals and humans, the impact of moderate intensity exercise training on fibrinolytic activities and nitric oxide (NO) bioavailability has not been well documented. Therefore, the purpose of the current study was to examine the impact of moderate intensity aerobic exercise training on fat mass, blood lipid profiles, fibrinolytic activity, and NO levels in high-fat-diet induced rats. The body weight, fat mass, blood lipid profiles, fibrinolytic activity, and nitrite/nitrate were measured pre- and postexercise (10 weeks) training. The body weight and fat mass reduced significantly in the exercise (EX) group compared to the control (CON) group. Blood lipid profiles and low-density lipoprotein were unchanged in the EX group compared to the CON group. However, triglyceride and free fatty acid were significantly lower in the EX group compared to the CON group, and high-density lipoprotein was significantly greater in the EX group compared to the CON group. In addition, fibrinolytic activity and nitrite/nitrate were significantly greater in the EX compared to the CON group. These results suggest that 10 weeks of the moderated intensity aerobic exercise training improves blood lipid profiles, fibrinolytic activity, and the nitrite/nitrate ratio, which may improve vascular health and reduce obesity-related cardiovascular disease risks in high-fat- diet induced rats.
Blood lipid profiles;fat mass;fibrinolytic activity;nitric oxide;
 Cited by
American college of sports medicine. 2006. ACSM’s Guide-lines for Exercise Testing and Prescription (7th eds). Lippinocott, Williams & Wilkins Philadelphis, PA, USA.

Andersen, L. B. and Haraldsdottir, J. 1995. Coronary heartdisease risk factors, physical activity, and fitness in young Danes. Med. Sci. Sports Exerc. 27, 158-163.

Andrade, A. M., Coutinho, S. R., Silva, M. N., Mata, J.,Vieira, P. N., Minderico, C. S., Melanson, K. J., Baptista, F.,Sardinha, L. B. and Teixeira, P. J. 2010. The effect of physicalactivity on weight loss is mediated by eating self-regulation. Patient Educ. Couns. 79, 320-326. crossref(new window)

Astrup, T. and Mullertz, S. 1952. The fibrin plate method for estimating fibrinolytic activity. Arch. Biochem. Biophys. 40, 346-351. crossref(new window)

Beak, I. Y. 2009. Exercise and energy metabolism. Deahanmedia, Seoul, Korea.

Beak, Y. H. and Lee, S. H. 2010. The effect of aerobic exercise and allium tuberosum intake on blood lipids, MDA and antioxidantenzyme in rats. J. Life Sci. 20, 245-252. crossref(new window)

Bedford, T. G., Tipton, C. M., Wilson, N. C., Oppliger, R.A. and Glsolfi, C. V. 1979. Maximum oxygen consumptionof rats and its changes with various experimental procedures. J. Appl. Physiol. Respir. Environ. Physiol. 47, 1278-1283.

Coiro, V., Casti, A., Rubino, P., Manfredi, G., Maffei, M.L., Melani, A., Saccani Jotti, G. and Chiodera, P. 2007. Freefatty acids inhibit adrenocorticotrophic and cortisol secretionstimulated by physical exercise in normal men. Clin. Endocrinol. 66, 740-743. crossref(new window)

David, C. N., David, W. B., Diane, B., Alan, C. U. and Cathy, C. N. 2002. Reducing diet and/or exercise training decreasesthe lipid and lipoprotein risk factors of moderately obesewomen. J. Am. Coll. Nutr. 21, 344-350. crossref(new window)

De Ciuceis, C., Porteri, E., Rizzoni, D., Corbellini, C., LaBoria, E., Boari, G. E., Pilu, A., Mittempergher, F., Di Betta, E., Casella, C., Nascimbeni, R., Rosei, C. A., Ruggeri, G.,Caimi, L and Rosei, E. A. 2011. Effects of weight loss onstructural and functional alterations of subcutaneous smallarteries in obese patients. Hypertension 58, 29-36. crossref(new window)

El-Sayed, M. S., Sale, C., Jones, P. G. and Chester, M. 2000. Blood hemostasis in exercise and training. Med. Sci. Sports Exerc. 32, 918-925.

Fantuzzi, G. 2005. Adipose tissue, adipokines and inflammation. J. Allergy Clin. Immunol. 155, 911-919.

Figueroa, A., Park, S. Y., Seo, D. Y., Sanchez-Gonzlez, M.A. and Beak, Y. H. 2011. Combined resistance and enduranceexercise training improves arterial stiffness, blood pressure,and muscle strength in postmenopausal women. Menopause 18, 980-984. crossref(new window)

Giovannoni, G., Land, J. M., Keir, G., Thompson, E. J. and Heales, S. J. 1997. Adaptation of the nitrate reductase andgriess reaction methods for the measurement of serum nitrateplus nitrite levels. Ann. Clin. Biochem. 34, 193-198. crossref(new window)

Glass, C. K. and Witztum, J. L. 2001. Atherosclerosis: Theroad ahead. Cell 104, 503-516. crossref(new window)

Goldberg, L., Elliot, D. L., Schultz, R. W. and Kloster, F.E. 1984. Changers in lipid and lipoprotein levels after weighttraining. JAMA 252, 504-506. crossref(new window)

Grassi, G., Seravalle, G., Scopelliti, F., Dell’Oro, R., Fattori,L., Quarti-Trevano, F., Brambilla, G., Schiffrin, E. L. and Mancia, G. 2010. Structural and functional alterations of subcutaneous small resistance arteries in severe human obesity. Obesity 18, 92-98. crossref(new window)

Haddock, B. L., Hopp Marshak, H. P., Mason, J. J. and Blix, G. 2000. The effect of hormone replacement therapy and exercise on cardiovascular disease risk factors in postmenopausal women. Sports Med. 29, 39-49. crossref(new window)

Han, S. S. 2001. The effect of regulary aerobic exercise bytreadmill on GL, TG, PL and serum lipid in rat. Kor. J. Physi.Eudc. 40, 953-964.

Hawiger, J. J. 2000. Platelets: receptors, adhesion, secretion. Academic Press. San Diego, USA.

Heo, S., Hong, K. Y. and Jang, J. H. 2006. Change of plasmaleptin concentrations, obesity and blood lipid profiles accordingto the intensity of the exercise on rats. Korea Sport Research 17, 311-320.

Husain, K. and Hazelrigg, S. R. 2002. Oxidative injury due to chronic nitric oxide synthase inhibition in rat: effect of regular exercise on the heart. Biochim. Biophys. Acta. 1587, 75-82. crossref(new window)

Jacobs, K. A., Krauss, R. M., Fattor, J. A., Friedlander, A.L., Bauer, T. A., Hagobian, T. A., Wolfel, E. E. and Brooks,G. A. 2006. Endurance training has little effect on activemuscle free fatty acid, lipoprotein cholesterol, triglyceride net balances. Am. J. Physiol. Endocrinol. Metab. 291, 656-665. crossref(new window)

Jae, S. Y. and Park, W. H. 1998. The relationship of cardiopulmonaryfitness to plasma fibrinogen, plasminogen activatorinhibitor Type-1 (PAI-1), and Lipoprotein (a) [LP(a)]in healthy postmenopausal women. Kor. J. Sports Med. 16, 282-291.

Jungersten, L., Ambring, A., Wall, B. and Wennamalm, A.1977. Both physical fitness and acute exercise regulate nitricoxide formation in healthy humans. J. Appl. Physiol. 82,760-764.

Kim, S. B. 2013. Effects of combined aerobic and resistance exercise on fibrinolytic factors and carotid intima-media thickness in menopausal women. J. Kor. Soc. Living Environ. Sys. 20, 479-489.

Klein, S., Burke, L. E., Bray, G. A., Blair, S., Allison, D. B., Pi-Sunyer, X., Hong, Y. and Eckel, R. H. 2004. Clinical implications of obesity with specific focus on cardiovasculardisease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Foundation. Circulation 110, 2952-2967. crossref(new window)

Landmesser, U. and Helmut, D. 2007. Endothelial function and hypertension. Curr. Opin. Cardiol. 22, 316-320. crossref(new window)

Lee, H. H., OH, M. J., Min, D. S., Kim, J. O., Park, S. T.,Yoon, J. H. and Jung, I. G. 2005. Effect of treadmill exercise on plasma lipid profile and leptin concentration in high fatfed rats. Kor. J. Physi. Education 44, 507-518.

Lee, H. M., Seo, D. Y., Lee, S. H. and Beak, Y. H. 2010. Effects of exhaustive exercise and aged garlic extract supplementation on weight, adipose tissue mass, lipid profiles andoxidative stress in high fat diet induced obese rats. J. Life Sci. 20, 1889-1895. crossref(new window)

Maeda, S., Miyauchi, T., Kakiyama, T., Sugawara, J., Iemitsu,M., Irukayama-Tomobe, Y., Murakami, H., Kumagai, Y., Juno, S. and Matsuda, M. 2001. Effects of exercise training of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans. Life Sci. 69, 1005-1016. crossref(new window)

Martins, C., Morgan, L. M., Bloom, S. R. and Robertson, M. D. 2007. Effects of exercise on gut peptides, energy intake and appetite. J. Endocrinol. 193, 251-258 crossref(new window)

Mestek, M. L., Carner, J. C., Plaisance, E. P., Taylor, J. K., Alhassan, S. and Grandjean, P. W. 2006. Blood lipid responsesafter continuous and accumulated aerobic exercise. Int J. Sport Nutr. Exerc. Metab. 16, 245-254.

Min, D. S. 2005. Effect of treadmill exercise on plasma lipidprofile and leptin concentration in high fat fed rats. Master’s Thesis, Hannam University. Deajeon, Korea.

Mora, S., Lee, I. M., Buring, J. E. and Ridker, P. M. 2006. Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. JAMA 295, 1412-1419. crossref(new window)

Palmer, R. M., Ashton, D. S. and Moncada, S. 1988. Vascularendothelial cells synthesize nitric oxide from L-arginine. Nature 333, 664-666. crossref(new window)

Palmer, R. M., Ferrige, A. G. and Moncada, S. 1987. Nitric oxide release accounts for the biologic activity of endothelium derived factor. Nature 327, 524-526. crossref(new window)

Park, H. J. 2007. The effects of the existence and the nonexistence of participation of Korean traditional dance progrmaand β3-adrenergic receptor gene mutation on the function of immune system, inflammatory markers and anticoagulant inhibition for elderly women. Ph.d. Dissertation, Sookmyung Women’s university, Seoul, Korea.

Richter, E. A. and Ruderman, N. B. 2009. AMPK and thebiochemistry of exercise : implications for human health and disease. Biochem. J. 418, 261-275. crossref(new window)

Scjokman, C. P., Ingrid, H., Rutishauser, E. and Wallace, R.J. 1990. Pre and post game macronutrient intake of a group of elite Australian football players. Int. J. Sport Nutr. Exerc. Metab. 9, 60-96.

Son, Y. H. 2005. Effects of sports dance training on lipid superoxide production and anti-oxidant capacity in clmacterium women. Korea Sport Research 16, 25-34.

Sung, J. M., Bang, G. H., Kong, M. A., Kim, J. S. and Kang, H. S. 2012. The effects of aerobic exercise on blood lipids, stress and growth hormones of middle aged women. Exerc. Sci. 21, 446-455.

Virdis, A., Santini, F., Colucci, R., Duranti, E., Salvetti, G.,Rugani, I., Segnani, C., Anselmino, M., Bernardini, N., Blandizzi, C., Salvetti, A., Pinchera, A. and Taddei, S. 2011.Vascular generation of tumor necrosis factor-alpha reduces nitric oxide availability in small arteries from visceral fat of obese patients. J. Am. Coll. Cardiol. 58, 238-247. crossref(new window)

Woo, S. H., Kang, S. H., Woo, J. H. and Shin, K. O. 2013. Effects of exercise training on the relationship with brain-derivedneurotrophic factor expression and leptin mRNA expression in hypothalamus, serum leptin, and anti-obesity in high-fat diet-induced obese rats. J. Kor. Soc. Food Sci. Nutr. 42, 1585-1591. crossref(new window)

Yoon, C. J., Jeon, W. S., Kim, Y. W. and Moon, K. H. 2006. Effect of metformin on the expression of nitric oxide synthase in high fat fed obese rats. Kor. J. Androl. 24, 44-50.

Yoon, E. J., Park, S. H., Lee, H. and An, U. S. 2004. Effects of long-term training on blood coagulation and anticoagulants of resting and after high-intensity exercise. Kor. J. Physi. Educ. 43, 521-533.

Yoon, E. S., Jung, S. J. and Jae, S. Y. 2010. Effects of exercise training program on carotid intima-media thickness and brachial artery endothelium-dependent flow mediated vasodilation in obese adolescents. Exerc. Sci. 19, 165-174. crossref(new window)