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Roles of Steroid Receptor Coactivator-3 and TTF-1 in Lung Development and Lung Cancer
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  • Journal title : Journal of Life Science
  • Volume 25, Issue 12,  2015, pp.1439-1444
  • Publisher : Korean Society of Life Science
  • DOI : 10.5352/JLS.2015.25.12.1439
 Title & Authors
Roles of Steroid Receptor Coactivator-3 and TTF-1 in Lung Development and Lung Cancer
Kwak, Inseok;
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 Abstract
Steroid receptor coactivators (SRC) are transcriptional coactivators. Among SRCs, SRC-3 is the most studied in relation to different types of tumors. However, the role of SRC-3 in early lung development and lung cancer has not been well studied. The expression profiles of SRC-3 showed that SRC-3 contributed to bronchial and alveolar development in embryonic lung development. SRC-3 was strongly expressed in Clara cells and type II alveolar cells during fetal lung development (E17.5- E18.5), and SRC-3 was expressed in both cell types in the adult lung. TTF-1 was expressed in the lungs of heterozygote SRC-3 mice and Clara cell-specific-CCSP-TAg tumor mice, along with SRC-3 expression. The expression of TTF-1 was localized at transformed Clara cells and multifocal adenocarcinomas in lung cancer mice. However, SRC-3 was not expressed in the multifocal adenocarcinomas, suggesting that SRC-3 might not be involved in the invasiveness of lung cancer. Cotransfection of TTF-1 in Clara cell-specific mtCC cell lines resulted in significant activation of CCSP expression. However, cotransfection of SRC-3 had no significant effects on transient transfection. These in vivo and in vitro results suggest that SRC-3 does not play a significant role in lung tumor progression. In conclusion, SRC-3 is involved in bronchial and alveolar development in fetal and adult lungs, but it does not play an important role in the progression of Clara cell-derived lung cancer.
 Keywords
CCSP;lung cancer;lung development;SRC-3;TTF-1;
 Language
English
 Cited by
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