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Antioxidant, Antimicrobial and Anticancer Properties of Seven Traditional Herb-combined Remedies
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  • Journal title : Journal of Life Science
  • Volume 25, Issue 4,  2015, pp.406-415
  • Publisher : Korean Society of Life Science
  • DOI : 10.5352/JLS.2015.25.4.406
 Title & Authors
Antioxidant, Antimicrobial and Anticancer Properties of Seven Traditional Herb-combined Remedies
Lee, Moon Hee; Lee, Jae-wang; Park, Cheol; Han, Min Ho; Hong, Su Hyun; Choi, Yung Hyun;
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 Abstract
In this study, we investigated the antioxidant activities and compared other physiological properties including anti-cancer and antimicrobial effects of several traditional Korean herb-combined remedies such as Gilgyung-tang (GGT), Daihwangmokdan-tang (DHMDT), Sagan-tang (SGT), Socheonryongtang (SCRT), Sihocheonggan-tang (SHCGT), Sipyukmiyuki-eum (SYMYKE) and Hwangheuk-san (HHS), which were recorded in “Dong-eui-bo-gam” for “Ongjeo”. Total phenolic contents of the herb medicines were in a rich order of GGT < SYMYKE < SCRT < SHCGT < DHMDT < SGT < HHS. Among them, HHS appeared highest in superoxide dismutase-like activity, ferric reducing antioxidant power, scavenging of 2,2’-diphenyl-1-picrylhydrazyl, and 2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonate) cationic radical activity. Interestingly, there was a positive relationship between their total phenolic contents and their antioxidant activities. Although all of them showed anti-proliferative activities in human colon cancer HCT-116 cells, HHS was seven times higher than GGT. Antimicrobial activities against Escherichia coli and Helicobacter pylori were revealed only on SGT, SCRT, SYMYKE and HHS. Taken together, these findings reveal the potential use of traditional Korean herbal formulas as functional ingredients in antioxidant and physiological materials.
 Keywords
Anticancer activity;antimicrobial activity;antioxidant activity;traditional herb-combined remedies;
 Language
Korean
 Cited by
1.
5637 인체 방광암세포의 이동성과 침윤성에 미치는 황흑산(黃黑散)의 영향,심원석;김민서;박상은;최영현;홍상훈;

대한한방내과학회지, 2016. vol.37. 1, pp.65-76
1.
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2.
Two Cases of Erythema Multiforme(EM) Treated with Sihochunggan-tang gagambang, The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, 2016, 29, 3, 240  crossref(new windwow)
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Studies on Bioactive Substances and Antioxidant Activities of Marine Algae from Jeju Island, Journal of Marine Bioscience and Biotechnology, 2016, 8, 1, 30  crossref(new windwow)
 References
1.
Bauer, A. W., Kirby, W. M., Sherris, J. C and Turck, M. 1966. Antibiotic susceptibility testing by a standardized single disk method. Am. J. Clin. Pathol. 45, 493-496.

2.
Benzie, I. F. F. and Strain, J. J. 1996. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal. Biochem. 239, 70-76. crossref(new window)

3.
Blios, M. S. 1958. Antioxidant determination by the use of a stable free radical. Nature 26, 1158-1200.

4.
Cataldi, A. 2010. Cell responses to oxidative stressors. Curr. Pharm. Des. 16, 1387-1395. crossref(new window)

5.
Choi, S. W., Kan, H., Sin, B. S, Kim, S. H. Choi, S. H. and Ahn, K. S. 2009. Effect of bupeuri raix on inflammatory cytokine secretion to HMC and mouse immune cells. Kor. J. Ori. Med. Physiol. Pathol. 23, 150-157.

6.
Choi, Y., Kim, M., Shin, J. J., Park, J. M. and Lee, J. 2003. The antioxidant activities of the some commercial teas. J. Kor. Soc. Food Sci. Nutr. 32, 723-727. crossref(new window)

7.
Chu, C. K., Jung, S. K., Jung, H. J. and Kim, J. J. 2010. Research on anti-inflammatory effects of forsythiae fructus. Kor. J. Ori. Int. Med. 31, 242-253.

8.
Chung, S. H., Moon, Y. J., Kim, S. G., Kim, K. Y., Lee, K. T., Kim, H. K. and Whang, H. K. 2008. Isolation of flavonoids from carthami flos and their antioxidative activity. Yakhak Hoeji 52, 241-251.

9.
Dröge, W. 2002. Free radicals in the physiological control of cell function. Physiol. Rev. 82, 47-95. crossref(new window)

10.
Emerit, J., Edeas, M. and Bricaire, F. 2004. Neurodegenerative diseases and oxidative stress. Biomed. Pharmacother. 58, 39-46. crossref(new window)

11.
Fridovich, I. 1998. Oxygen toxicity, a radical explanation. J. Exp. Biol. 201, 1203-1209

12.
Gordon, M. F. 1990. The mechanism of antioxidant action in vitro, pp. 1-18. In: Hudson, B. J. F. (ed.), In Food Antioxidants. Elsevier Applied Food Science publishers, London, UK.

13.
Han, I. S. 2013. Anti-inflammatory effect of sihocheonggantang extraction. Master dissertation, Sangji University, Seoul, Korea.

14.
Han, J. H. and Lee, S. Y. 2011. Comparing medical efficacy of Socheongyong-tang with lactic acid bacteria fermented Socheongyong-tang. Kor. J. Ori. Med. Physiol. Pathol. 5. 246-256.

15.
Hansen, M. B., Nielsen, S. E. and Berg, K. 1989. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 119, 203-210. crossref(new window)

16.
Heo, J. Donguibogam, 1999. pp. 1433-1439. In: Kim, K. J. (ed.), Beopinmunhwasa publishers, Seoul, Korea.

17.
Hollman, P. C. H. 2001. Evidence for health effects of plant phenols: localor systemic effects? J. Sci. Food Agric. 81, 842-852. crossref(new window)

18.
Hong, S. H., Park, C., Han, M. H., Kim, H. J., Lee, M. H. and Choi, Y. H. 2014. Effects of Platycodon grandiflorum on the induction of autophagy and apoptosis in HCT-116 human colon cancer cells. J. Life Sci. 24, 1244-1251. crossref(new window)

19.
Jang, M., Seo, J., Lee, J. H. and Kim, G. H. 2010. Antibacterial activities of essential oil from Zanthoxlum schinifolium against foodborne pathogens. Kor. J. Food Cook Sci. 26, 206-213.

20.
Kim, B. J. 2000. Antimicrobial activities of the extracts of Platycodon glandiforum A. De. Candolle on the growth of Listeria monocytogenes. Kor. J. Soc. Food Sci. 16, 379-384.

21.
Kim, C. J., Cho, S. K., Choi, C. S. and Choi, Y. S. 1990. Hepatoprotective activities of traditional Korean Herbal prescritions. Kor. J. Pharmacongn. 21, 223-224.

22.
Kim, D. O., Jeong, S. W. and Lee, C. Y. 2003. Antioxidant capacity of phenolic phytochemicals from various cultivars of plums. Food Chem. 81, 321-326. crossref(new window)

23.
Kim, H. W., Lim, C. Y., Kim, B. Y. and Cho, S. I. 2014. So-Cheong-Ryong-Tang, a herbal medicine, modulates inflammatory cell infiltration and prevents airway remodeling via regulation of interleukin-17 and GM-CSF in allergic asthmain mice. Pharmacogn. Mag. 10, 506-511. crossref(new window)

24.
Kim, S. Y., Lee, E. B. and Jeong, E. J. 2009. Anti-Inflammatory action of the fractions of Platycodi radix. Kor. J. Food Nutr. 22, 618-624.

25.
Kim, Y. K., Ha, H. K., Lee, J. H. and Kim, C. S. 2002. COX-2 inhibition and anti-inflammatory effects of traditional herbal medicine. Kor. J. Ori. Med. 8, 65-74.

26.
Lee, I. S., Choi, M. C. and Moon, H. Y. 2000. Effect of Platycodon grandiflorum A. DC extract on the bronchus diseases bacteria. Kor. J. Biotech. Bioeng. 15, 162-166.

27.
Lee, J. Y., Lee, J. M., Lee, C. H., Cho, J. H., Jang, J. B. and Lee, K. S. 2010. Antitumor and immunomodulatory activities of Platycodon grandiflorum. J. Ori. Obes. Gynecol. 23.10-19.

28.
Li, Z., Li, L. J., Sun Y. and Li, J. 2007. Identification of natural compounds with anti-hepatitis B virus activity from Rheum palmatum L. ethanol extract. Chemotherapy 53, 320-326. crossref(new window)

29.
Lim, H. R. and Shin, S. W. 2010. Effects of the essential oil components from Ligusticum chuanxiong on proinflammatory mediators of Raw 264.7 macrophage cells. Nat. Prod. Sci. 16, 259-264.

30.
Lim, Y., Park, K. R., Lee, D. U., Kim, Y. S. and Kim, H. P. 2008. Effects of the constituents of gardenia fructus on prostaglandin and NO production. Biomolecules Therapeutics 16, 82-86. crossref(new window)

31.
Liu, L., Sun, Y., Laura, T., Liang, X., Ye, H. and Zeng, X. 2009. Determination of polyphenolic content and antioxidant activity of kudingcha made from Ilex kudingcha C. J. Tseng. Food Chem. 112, 35-41. crossref(new window)

32.
Luximon-Ramma, A., Bahorun, T., Soobrattee, A. M. and Aruoma, O. I. 2005. Antioxidant activities of phenolic, proanthocyanidin and flavonoid components in extracts of Acacia fistula. J. Agric. Food Chem. 50, 5042-5047.

33.
Markland, S. and Markland, G. 1974. Involvement of superoxide radical in the autoxidation of pyrogallol and convenient assay for superoxide dismutase. Eur. J. Biochem. 47, 469-472. crossref(new window)

34.
Mello, L. D., Hernandez, S., Marrazza, G., Mascini, M. and Kubota, L. T. 2006. Investigations of the antioxidant properties of plant extracts using a DNA-electrochemical biosensor. Biosens Bioelectron 21, 1374-1382. crossref(new window)

35.
Milne, L., Nicotera, P., Orrenius, S. and Burkitt, M. 1993. Effects of glutathione and chelating agents on copper-mediated DNA oxidation: Prooxidant and antioxidant properties of glutathione. Arch. Biochem. Biophys. 304, 102-109. crossref(new window)

36.
Mo, J. H., Lee, S. E., Wee, J. H., Lee, J. E., Rhee, C. S., Lee, C. H. and Kim, D. Y. 2013. Anti-allergic effects of So-Cheong- Ryong-Tang, a traditional Korean herbal medicine, in an allergic rhinitis mouse model. Eur. Arch. Otorhinolaryngol. 270, 923-30. crossref(new window)

37.
Paik, S. B., Kyung, S. H., Kim, J. J. and Oh, Y. S. 1996. Effect of bioactive substance extracted from Rheum undulatum on control of cucumber powdery mildew. Kor. J. Plant Pathol. 12. 85-90.

38.
Park, K. H., Kim, S. Y. and Chae, H. J. 2007. Selection of oriental medicinal plants for screeninf of anticancer agents. Kor. J. Biotechnol. Bioeng. 22. 139-145.

39.
Park, U. Y., Chang, D. S. and Cho, H. R. 1992. Screenging of antimicrobial activity for medicinal herb extracts. J. Kor. Soc. Food Nurt. 21. 91-96

40.
Robards, K., Prernzler, P. D., Tucker, G. and Swatsitang, P. and Glover, W. 1999. Phenolic compounds and their role in oxidative processes in fruits. Food Chem. 66, 401-436. crossref(new window)

41.
Roberta, R., Nicoletta, P., Anna, P., Ananth, P., Min., Y. and Catherine, R. E. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. J. Free Rad. Biol. Med. 26, 1231-1237. crossref(new window)

42.
Ryu, J. H., Jang, J. H., Lee, S. Y., Lee, H. J. and Han, Y. N. 1998. Inhibitors of nitric oxide synthesis from ginseng in activated macrophages. J. Ginseng Res. 22, 181-187.

43.
Singleton, V. L. and Rossi, J. A. 1965. Colorimetry of total phenolics with phosphomolybdic–phosphotungstic acid reagents. Am. J. Enol. Vitic. 16, 144-158.

44.
Shung, S. H., Moon, Y. J., Kim, S. G., Kim, K. Y., Lee, K. T., Kim, H. K. and Whang, Y. K. 2008. Isolation of flavonoids from Carthami Flos and their antioxidative activity. Yakhak Hoeji 52, 241-251.

45.
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M. and Mazur, M. 2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact 10, 1-40.

46.
Vaya, J., Belinky, P. A. and Aviram, M. 1997. Antioxidant constituents from licorice roots: Isolation, structure elucidation and antioxidative capacity toward LDL oxidation. Free Radic. Biol. Med. 23, 302-313. crossref(new window)

47.
Wolfenden, B. S. and Willson, R. L. 1982. Radical-cations as reference chromogens in kinetic studies of one-electron transfer reactions: pulse radiolysis studies of 2, 2’-azinobis-(3-ethylbenzthiazoline-6-sulphonate). J. Chem. Soc. Perkin. Trans. 2, 805-812.

48.
Xu, Q., Mori, H., Sakamoto, O., Uesugi, Y. and Koda, A. 1989. Immunological mechanisms of antitumor activity of some kinds of crude drugs on tumor necrosis factor production. Int. J. Immunopharmacol. 11, 607-613. crossref(new window)

49.
Yang, Z. C., Wang, B. C., Yang, X. S., Wang Q. and Ran, L. 2005. The synergistic activity of antibiotics combined with eight traditional Chinese medicines against two different strains of Staphylococcus aureus. Colloids Surf. B. Biointerfaces 25, 79-81.

50.
Yoon, S. B., Han, H. S. and Lee, Y. J. 2011. Effect of scutellariae radix extract on the proinflammatory mediators in Raw 7 cells induced by LPS. Kor. J. Herbology 26, 75-81.

51.
Yoon, T. S., Cheon, M. S., Kim, S. J., Lee A. Y., Moon, B. C., Chun, J. M., Choo, B. K. and Kim, H. K. 2010. Evaluation of solvent extraction on the anti-inflammatory efficacy of Glycyrrhiza uralensis. Kor. J. Med. Crop. Sci. 18, 28-33.

52.
Yoon, Y. H., Kim, S. B., Kang, O. H., Mun, S. H., Seo, Y. S., Yang, D. W., Kang, D. H., Wi, G., Lim, J. S., Kim, M. R., Kwak, N. W., Komg, R. and Kwon, D. Y. 2014. The study of anti-inflammatory effect of Suryeon-hwan water extract in RAW 264.7 cells. Kor. J. Herbology 29. 125-135. crossref(new window)