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Improvement of Learning Behavior of Mice by an Antiacetylcholinesterase and Neuroprotective Agent NX42, a Laminariales-Alga Extract
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 Title & Authors
Improvement of Learning Behavior of Mice by an Antiacetylcholinesterase and Neuroprotective Agent NX42, a Laminariales-Alga Extract
Lee, Bong-Ho; Stein, Steven M.;
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Brown-alga-derived natural agent NX42, mainly composed of algal polysaccharides and phlorotannins, showed mild but dose-dependent inhibition of acetylcholinesterase with . Phlorotannin-rich fraction of NX42 showed substantial increase of the activity by more than one order of magnitude () and significant protection of SK-N-SH cells from oxidative stress by . Learning trials of mice for 5 consecutive days revealed electric-shock treatment during learning period significantly retarded learning process, whereas NX42-treated mice showed significant resistance against leaning deficiency possibly mainly due to anticholinesterase and neuroprotective activities of phlorotannin.
learning behavior;anticholinesterase;neuroprotective;alga extract;
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