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Co-treatment with Fermented Black Raspberry and Red Ginseng Extracts Improves Lipid Metabolism and Obesity in Rats Fed with a High-fat and High-cholesterol Diet
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 Title & Authors
Co-treatment with Fermented Black Raspberry and Red Ginseng Extracts Improves Lipid Metabolism and Obesity in Rats Fed with a High-fat and High-cholesterol Diet
Lee, Min Jung; Choi, Hye Ran; Lee, Jung-Hyun; Lee, Su Jung; Kwon, Ji Wung; Choi, Kyung-Min; Cha, Jeong-Dan; Hwang, Seung-Mi; Park, Jong Hyuk; Lee, Sang Cheon; Park, Pill Jae; Lee, Tae-Bum;
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 Abstract
This study investigated the effects of fermented black raspberry (BR) and red ginseng (RG) extract co-treatment on lipid metabolism and obesity in rats fed with a high fat/high cholesterol diet (HFHCD) for 12 weeks. Compared to the corresponding values in rats fed with a HFHCD, total cholesterol and low-density lipoprotein (LDL)-cholesterol and triglyceride levels decreased whereas high-density lipoprotein (HDL)-cholesterol levels increased in rats treated with fermented BR and RG extracts. These extracts significantly increased the expression of HMG-CoA reductase, LDL receptor, and sterol regulatory-element-binding protein-2 (SREBP-2) mRNA, but decreased the mRNA expression of SREBP-1. Additionally the serum levels of leptin and fatty acid synthase were decreased. Moreover, supplementation with fermented BR and RG effectively increased fecal cholesterol excretion. These results suggest that fermented BR and RG extracts might be effective at preventing hypercholesterolemia and obesity.
 Keywords
black raspberry;red ginseng;lipid metabolism;obesity;fermented extract;
 Language
Korean
 Cited by
1.
Comparison of the phenolic composition and antioxidant activity of Korean black raspberry, Bokbunja, (Rubus coreanus Miquel) with those of six other berries, CyTA - Journal of Food, 2016, 1  crossref(new windwow)
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