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Anti-amnesic and Neuroprotective Effects of Artemisia argyi H. (Seomae mugwort) Extracts
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 Title & Authors
Anti-amnesic and Neuroprotective Effects of Artemisia argyi H. (Seomae mugwort) Extracts
Ha, Gi-Jeong; Lee, Doo Sang; Seung, Tae Wan; Park, Chang Hyeon; Park, Seon Kyeong; Jin, Dong Eun; Kim, Nak-Ku; Shin, Hyun-Yul; Heo, Ho Jin;
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The anti-amnesic effect of Artemisia argyi H against trimethyltin (TMT)-induced learning and memory impairment and its neuroprotective effect against -inducedoxidative stress were investigated. Cognitive behavior was examined by Y-maze and passive avoidance test for 4 weeks, which showed improved cognitive functions in mice treated with the extract. In vitro neuroprotective effects against -induced oxidative stress were examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium-bromide and lactate dehydrogenase (LDH) assays. A. argyi H. extract showed protective effects against -induced neurotoxicity; moreover, LDH release into the medium was inhibited. Finally, high-performance liquid chromatography (HPLC) analysis showed that eupatilin and jaceosidin were the major phenolic compounds in A. argyi H. extract. These results suggest that A. argyi H. could be a good source of functional substances to prevent neurodegenerative diseases.
Artemisia argyi H;Seomae mugwort;trimethyltin;neurodegeneration;
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