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Effect of a Mixed Extract of Fenugreek Seeds and Lespedeza cuneata on Testosterone Deficiency Syndrome
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 Title & Authors
Effect of a Mixed Extract of Fenugreek Seeds and Lespedeza cuneata on Testosterone Deficiency Syndrome
Lee, Kyeong Soo; Lee, Eun Kyung; Kim, Shin Yeon; Kim, Tae Hwan; Kim, Hyun Pyo;
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 Abstract
Testosterone deficiency syndrome (TDS) is normally observed in elderly men and is a clinical and biochemical syndrome, characterized by a decline in plasmic testosterone levels resulting in a significant decrease in quality of life. The aim of this study was to evaluate the effect of a mixed extract of fenugreek seeds and Lespedeza cuneata (YHM) on TDS. Rats were divided into three groups: the negative control, YHM-40 (40 mg/kg), and YHM-80 (80 mg/kg) groups. After 4 weeks of YMH administration, an increase was observed in the plasmic testosterone levels, vastus lateralis muscular strength, forced swimming time, total sperm counts, and motile sperm counts in YHM-40 and YHM-80 groups compared to the negative control group. Moreover, sex hormone binding globulin, the epididymal fat pad, total plasmic cholesterol, and triglyceride levels were significantly decreased in the YHM-fed groups. However, prostate specific antigen, aspartate aminotransferase, and alanine aminotransferase levels did not differ among the groups. These results suggest that YHM may enhance testosterone levels in elderly men and alleviate TDS without common side effects.
 Keywords
testosterone deficiency syndrome;testosterone;fenugreek seeds;Lespedeza cuneata;
 Language
Korean
 Cited by
1.
호로파와 야관문 복합추출물이 과산화수소로 산화적 스트레스가 가해진 TM3 세포의 테스토스테론 합성에 미치는 영향,이경수;이은경;서윤희;최수영;

Journal of Applied Biological Chemistry, 2016. vol.59. 4, pp.305-311 crossref(new window)
1.
Effects of the mixture of fenugreek seeds and Lespedeza cuneata extracts on testosterone synthesis in TM3 cells oxidative stressed with H2O2, Journal of Applied Biological Chemistry, 2016, 59, 4, 305  crossref(new windwow)
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