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Anti-obesity Effects of Ethanolic Extract of Polygonatum sibiricum Rhizome in High-fat Diet-fed Mice
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 Title & Authors
Anti-obesity Effects of Ethanolic Extract of Polygonatum sibiricum Rhizome in High-fat Diet-fed Mice
Ko, Jong-Hee; Jeon, Woo-Jin; Kwon, Hyuk-Sang; Yeon, Seung-Woo; Kang, Jae-Hoon;
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We investigated the anti-obesity effects of ethanolic extract (ID1216) of Polygonatum sibiricum rhizome and its potential underlying mechanism in an animal model. ID1216 treatment decreased body weight gain and white adipose tissue weight in the prevention study. The mRNA levels of sirtuin-1 (SIRT1), peroxisome proliferator-activated receptor coactivator- (), and peroxisome proliferator-activated receptor () significantly increased in the epididymal white adipose tissue of ID1216-administered mice. The stimulation effects of ID1216 on these gene expressions were also observed in a cell-based assay using differentiated 3T3-L1 adipocytes. In addition, similar to orlistat, ID1216 treatment improved weight gain and reduced epididymal fat in the treatment model. These results suggest that ID1216 has potential as an anti-obesity agent by modulating the expression of genes related to thermogenesis, lipid metabolism and fatty acid oxidation.
obesity;Polygonatum sibiricum;sirtuin-1;
 Cited by
황정 에탄올 추출물의 비만 조절 유전자에 대한 효과,전우진;이도섭;손서연;서윤지;연승우;강재훈;

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