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Phytochemicals and Antioxidant Activity of Codonopsis lanceolata Leaves
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 Title & Authors
Phytochemicals and Antioxidant Activity of Codonopsis lanceolata Leaves
Kim, Gi Ho; Kim, Na Yeon; Kang, Shin-Ho; Lee, Hwa Jin;
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Phytochemicals in Codonopsis lanceolata leaves were saponins, triterpenes, tannins, and flavonoids, not alkaloids. The levels of total polyphenols and flavonoids in Codonopsis lanceolata leaves were measured to evaluate the antioxidant activity. C. lanceolata leaves showed strong 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and potent reducing power. In addition, C. lanceolata leaf extracts inhibited production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated RAW 264.7 cells. To examine active phytochemical for antioxidant activity, aglycone fraction of C. lanceolata leaves was analyzed by high performance liquid chromatography (HPLC). Luteolin was identified as a main component of aglycone fraction and showed potent antioxidant activity as determined by a DPPH radical scavenging assay and reducing power test. These results suggest that C. lanceolata leaves are a good source of antioxidants.
Codonopsis lanceolata leaf;Campanulaceae;polyphenol;flavonoid;antioxidant activity;
 Cited by
잘피(Zostera marina) 추출물의 항균효과에 대한 연구,이소연;김보애;신동철;박관순;양재찬;

한국유화학회지, 2016. vol.33. 2, pp.225-231 crossref(new window)
Antioxidant Activity and Tyrosinase Inhibitory Effects of Fallopia sachalinensis Rhizome Ethanol Extract, Journal of Investigative Cosmetology, 2016, 12, 1, 15  crossref(new windwow)
Devasagayam TPA, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS, Lele RD. Free radicals and antioxidants in human health: Current status and future prospects. J. Assoc. Physician. I. 52: 794-804 (2004)

Alfadda AA, Sallam RM. Reactive oxygen species in health and disease. J. Biomed. Biotechnol. 2012: 936486 (2012)

Khurana S, Piche M, Hollingsworth A, Venkataraman K, Tai TC. Oxidative stress and cardiovascular health: Therapeutic potential of polyphenols. Can. J. Physiol. Pharm. 91: 198-212 (2013) crossref(new window)

Kancheva VD, Kasaikina OT. Bio-antioxidants-a chemical base of their antioxidant activity and beneficial effect on human health. Curr. Med. Chem. 20: 4784-4805 (2013) crossref(new window)

Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn. Rev. 4: 118-126 (2010) crossref(new window)

Alok S, Jain SK, Verma A, Kumar M, Mahor A, Sabharwal M. Herbal antioxidant in clinical practice: A review. Asian Pac. J. Trop. Biomed. 4: 78-84 (2014)

Yoo HH, Baek SH, Park YK, Lee SH, Kim CM, Lee KS, Park MK, Park JH. Quality control of dired roots of Codonopsis lanceolata. Kor. J. Pharmacogn. 33: 85-87 (2002)

He X, Kim SS, Park SJ, Seong DH, Yoon WB, Lee HY, Park DS, Ahn JH. Combined effects of probiotic fermentation and high-pressure extraction on the antioxidant, antimicrobial, and antimutagenic activities of deodeok (Codonopsis lanceolata). J. Agr. Food Chem. 58: 1719-1725 (2010) crossref(new window)

Xu LP, Wang H, Yuan Z. Triterpenoid saponins with anti-inflammatory activity from Codonopsis lanceolata. Planta Med. 74: 1412-1415 (2008) crossref(new window)

Cho KS, Kim SJ, Park SH, Kim SJ, Park TS. Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. J. Med. Food 12: 1293-1301 (2009) crossref(new window)

Kim MH, Lee JH, Yoo DS, Lee YG, Byeon SE, Hong EK, Cho JY. Protective effect of stress-induced liver damage by saponin fraction from Codonopsis lanceolata. Arch. Pharm. Res. 32:1441-1446 (2009) crossref(new window)

Kim SS, Jeong MH, Seo YC, Kim JS, Kim NS, Woon WB, Ahn JH, Hwang B, Park DS, Park SJ, Lee HY. Comparison of antioxidant activities by high pressure extraction of Conodopsis laneolata from different production areas. Korean J. Medicinal Crop. Sci. 18:248-254 (2010)

Li JP, Liang ZM, Yuan Z. Triterpenoid saponins and anti-inflammatory activity of Codonopsis lanceolata. Pharmazie 62: 463-436 (2007)

He X, Zou Y, Yoon WB, Park SJ, Park DS, Ahn JH. Effects of probiotic fermentation on the enhancement of biological and pharmacological activities of Codonopsis lanceolata extracted by high pressure treatment. J. Biosci. Bioeng. 112: 188-193 (2011) crossref(new window)

Cha A, Choi YS, Jin YJ, Sung MK, Koo YC, Lee KW, Park TS. Antilipogenic and anti-inflammatory activities of Codonopsis lanceolata in mice hepatic tissues after chronic ethanol feeding. J. Biomed. Biotechnol. 2012: 141395 (2012)

Choi HK, Won EK, Jang YP, Choung SY. Antiobesity effect of Codonopsis lanceolata in high-calorie/high-fat-diet-induced obese rats. Evid.-Based. Compl. Alt. 2013: 210297 (2013)

Kim EJ, Yang WS, Kim JH, Park JG, Kim HG, Ko JY, Hong YD, Rho HS, Shin SS, Sung GH, Cho JY. Lancemaside a from Codonopsis lanceolata modulates the inflammatory responses mediated by monocytes and macrophages. Mediat. Inflamm. 2014: 405158 (2014)

Byeon SE, Choi WS, Hong EK, Lee JH, Rhee MH, Park HJ, Cho JY. Inhibitory effect of saponin fraction from Codonopsis lanceolata on immune cell-mediated inflammatory responses. Arch. Pharm. Res. 32: 813-822 (2009) crossref(new window)

Whang WK, Park KY, Chung SH, Oh IS, Kim IH. Flavonoids from Codonopsis lanceolata leaves. Kor. J. Pharmacogn. 25: 204-208 (1994)

Lee YG, Kim JY, Lee JY, Byeon SE, Hong EK, Lee JH, Rhee MH, Park HJ, Cho JY. Regulatory effects of Codonopsis lanceolata on macrophage-mediated immune responses. J. Ethnopharmacol. 112: 180-188 (2007) crossref(new window)

Park EA. Physicochemical characteristics and antioxidant activities of Codonopsis lanceolata leaves. Korean J. Culin. Res. 20: 183-192 (2014)

Uddin R, Saha MR, Subhan N, Hossain H, Jahan IA, Akter R, Alam A. HPLC-analysis of polyphenolic compounds in Gardenia jasminoides and determination of antioxidant activity by using free radical scavenging assays. Adv. Pharm. Bull. 4: 273-281 (2014)

Aziz MA. Qualitative phytochemical screening and evaluation of anti-inflammatory, analgesic and antipyretic activities of Microcos paniculata barks and fruits. J. Integr. Med. 13: 173-184 (2015) crossref(new window)

Padda MS, Picha DH. Methodology optimization for quantification of total phenolics and individual phenolic acids in sweetpotato (Ipomoea batatas L.) roots. J. Food Sci. 72: C412-C416 (2007) crossref(new window)

Blois MS. Antioxidant determinations by the use of a stable free radical. Nature 181: 1199-1200 (1958) crossref(new window)

Lee HJ, Park JH, Jang DI, Ryu JH. Antioxidant components from Broussonetia kazinoki. Yakhak Heoji 41: 439-443 (1997)

Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients 2: 1231-1246 (2010) crossref(new window)

Malireddy S, Kotha SR, Secor JD, Gurney TO, Abbott JL, Maulik G, Maddipati KR, Parinandi NL. Phytochemical antioxidants modulate mammalian cellular epigenome: Implications in health and disease. Antioxid. Redox Sign. 17: 327-339 (2012) crossref(new window)

Kennedy DO. Polyphenols and the human brain: Plant "secondary metabolite" ecologic roles and endogenous signaling functions drive benefits. Adv. Nutr. 5: 515-533 (2014) crossref(new window)

Na GM, Han HS, Ye SH, Kim HK. Extraction characteristics antioxidative activity of Cassia tora L. extracts. J. Korean Soc. Food Cult. 19: 499-505 (2004)

Seelinger G, Merfort I, Schempp CM. Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. Planta Med. 74: 1667-1677 (2008) crossref(new window)

Rahman I. Dietary polyphenols mediated regulation of oxidative stress and chromatin remodeling ininflammation. Nutr. Rev. 66: S42-S45 (2008) crossref(new window)

Rathee P, Chaudhary H, Rathee S, Rathee D, Kumar V, Kohli K. Mechanism of action of flavonoids as anti-inflammatory agents: A review. Inflamm. Allergy Drug Targets 8: 229-235 (2009) crossref(new window)

Choi JS, Islam MN, Ali MY, Kim YM, Park HJ, Sohn HS, Jung HA. The effects of C-glycosylation of luteolin on its antioxidant, anti-alzheimer's disease, anti-diabetic, and anti-inflammatory activities. Arch. Pharm. Res. 37: 1354-1363 (2014) crossref(new window)

Jeong CH, Shim KH. Chemical composition and antioxidative activities of Platycodon grandiflorum leaves and stems. J. Korean Soc. Food Sci. Nutr. 35: 511-515 (2006) crossref(new window)