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Chitosan Nanoparticle System for Improving Blood Circulation
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 Title & Authors
Chitosan Nanoparticle System for Improving Blood Circulation
Lee, Ji-Soo; Yoon, Hyun-Sook; Kim, Eun Suh; Nam, Hee Sop; Lee, Hyeon Gyu;
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The principal objective of this study was to produce a chitosan nanoparticle (NP) system for improving blood circulation. Chitosan NPs were prepared using fucoidan and acid (PGA), denoted as CS/Fu and CS/Fu/PGA NPs, respectively. As the chitosan concentration was increased, the activated partial thromboplastin time (APTT) of the NPs significantly increased (p<0.05). When the concentration of fucoidan and was 5-20 and , respectively, the size of the CS/Fu and CS/Fu/PGA NPs was approximately 200 and 100 nm, respectively. With an increase in the fucoidan and PGA concentration, the APTT of CS/Fu and CS/Fu/PGA NPs significantly increased (p<0.05). These results suggest that CS/Fu and CS/Fu/PGA NPs could be used as a potent NP system for improving blood circulation.
blood circulation;activated partial thromboplastin time;nanoparticle;chitosan;
 Cited by
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