JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Inhibitory Effect of Penthorun chinense Extract on Allergic Responses in vitro and in vivo
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Journal of Food Hygiene and Safety
  • Volume 30, Issue 4,  2015, pp.376-382
  • Publisher : The Korean Society of Food Hygiene and Safety
  • DOI : 10.13103/JFHS.2015.30.4.376
 Title & Authors
Inhibitory Effect of Penthorun chinense Extract on Allergic Responses in vitro and in vivo
Jo, So young; Kim, Young Mi;
  PDF(new window)
 Abstract
Allergic diseases have rapidly increased in recent years. Mast cells play a critical role in IgE-mediated allergy responses and, therefore, closely associated with rhinitis, asthma, and atopic dermatitis. We studied anti-allergic effect of Penthorum chinense extract (PCE) in vitro and in vivo. PCE inhibited the degranulation of mast cells by antigen stimulation and its effect was dose-dependent and reversible in mast cells. PCE also suppressed the production of inflammatory cytokines such as TNF- and IL-4 by antigen in mast cells. Mechanistically, PCE inhibited the activation of Syk/LAT pathway which is a key signaling pathway for the activation of mast cells by antigen. Notably, PCE suppressed IgE-mediated allergic responses by antigen in mice. These results strongly suggest that PCE is a potential candidate for anti-allergic treatment.
 Keywords
Penthorum chinense extract (PCE);mast cell;syk kinases;allergy;anti-allergic effect;
 Language
Korean
 Cited by
 References
1.
Holgate, S.T. and Polosa, R.: Treatment strategies for allergy and asthma. Nat. Rev. Immunol., 8, 218-230 (2008). crossref(new window)

2.
Siraganian RP, Zhang J, Suzuki K and Sada K: Protein tyrosine kinase Syk in mast cell signaling. Mol Immunol, 38, 1229-1233 (2002). crossref(new window)

3.
Beaven MA: Our perception of the mast cell from Paul Ehrlich to now. Eur J Immunol, 39, 11-25 (2009). crossref(new window)

4.
Kang Mo Ahn: Role of Mast Cells in Allergic Inflammation and Innate Immunity. Korean Journal of Pediatrics, 47, 1137-1141 (2004).

5.
Xiao W, Nishimoto H, Hong H, Kitaura J, Nunomura S, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Ra C and Kawakami T : Positive and Negative Regulation of Mast Cell Activation by Lyn via the $Fc{\varepsilon}RI$. J Immunol, 175, 6885- 6892 (2005). crossref(new window)

6.
Roth K, Chen WM and Lin TJ: Positive and negative regulatory mechanisms in high-affinity IgE receptor-mediated mast cell activation. Arch, Immunol Ther Exp, 56, 385-399 (2008). crossref(new window)

7.
D G Raible, E S Schulman, J DiMuzio, R Cardillo and T J Post: Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils., J Immunol, 148, 3536-3542 (1992).

8.
Wang A, Lin L and Wang Y: Traditional Chinese Herbal Medicine Penthorum chinense Pursh: A Phytochemical and Pharmacological Review. Am J Chin Med, 43, 601-620 (2015). crossref(new window)

9.
Schwartz LB and Austen KF: Enzymes of the Mast cell Granule. J Inv Der, 74, 349-353 (1980).

10.
Korea Centers for Disease Control and Prevention: Trend increase in allergic diseases in children youth. 13, 1-13 (2010).

11.
Kyu Eon Kim: Allergic rhinitis diagnosis and treatment guidelines in Korea. AARD, 19, 807-885 (1999).

12.
Gilllan AM and Rivera J: The tyrosine kinase network regulating mast cell activation. Immunol Rev, 228, 149-169 (2009). crossref(new window)

13.
Sang Yup Lee and Gwang Ho In: Immunopathogenesis of Asthma. Tuberculosis and Respiratory Diseases, 60, 1-12 (2006).

14.
Gifillan AM and Tkaczyk C: Integrated signalling pathways for mast-cell activation. Nat Rev Immunol, 6, 218-228 (2006). crossref(new window)

15.
Giorgio Bertona, Attila Mocsaib and Clifford A. Lowellc: Src and Syk kinases: key regulators of phagocytic cell activation. cell press, 26, 208-214 (2005).

16.
Eun Lee, Byung Wook Park, Kum Jeong Huh and Heung Go: A Study on The Side Effects and Toxicity of Herbal Medicine. Journal of Korean Oriental Internal Medicine, 23, 222- 227 (2002).

17.
Kim JH, Kim AR, Kim HS, Kim HW, Park YH, You JS, Park YM, Her E, Kim HS, Kim YM and Choi WS: Rhamnus davurica leaf extract inhibits Fyn activation by antigen in mast cells for anti-allergic activity. BMC Complement Altern Med (2015).

18.
Kim JD, Kim do K, Kim HS, Kim AR, Kim B, Her E, Park KH, Kim HS, Kim YM and Choi WS: Morus bombycis extract suppresses mast cell activation and IgE-mediated allergic reaction in mice. J Ethnopharmacol, 146, 287-93 (2013). crossref(new window)