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Antioxidative Effect of Fermented Rhynchosia nulubilis in Obese Rats
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  • Journal title : Journal of Food Hygiene and Safety
  • Volume 30, Issue 4,  2015, pp.383-389
  • Publisher : The Korean Society of Food Hygiene and Safety
  • DOI : 10.13103/JFHS.2015.30.4.383
 Title & Authors
Antioxidative Effect of Fermented Rhynchosia nulubilis in Obese Rats
Bae, Gui-jeong; Ha, Bae-jin;
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 Abstract
This study was to examine the antioxidative activity of fermented Rhynchosia nulubilis (FRN) in obese rats. Oxidative stress due to reactive oxygen species (ROS) can cause oxidative damage to cells. Mitochondria are especially important in the oxidative stress as ROS have been found to be constantly generated as an endogen threat. Mitochondrial defense depends mainly on superoxide dismutase whereas microsomal defense depends on catalase, which is an enzyme abundant in microsomes. Seven weeks-aged female Sprague-Dawley rats were divided into four groups and fed high fat diets for 44 days. Also fermented Rhynchosia nulubilis was administered orally for 44 days at 7.5 ml/kg of body weight of rats. The antioxidative activities of fermented Rhynchosia nulubilis were measured by the superoxide dismutase, catalase, malondialdehyde levels in liver homogenate. The levels of malondialdehyde in FRN-treated groups were lower than those in obese groups. Superoxide dismutase and catalase levels were significantly increased. These results demonstrated that fermented Rhynchosia nulubilis had the inhibitive effects of oxidative stress in obese rats, suggesting that fermented Rhynchosia nulubilis would be used as an ingredient of the useful functional products.
 Keywords
Obese;Rhynchosia nulubilis;Anti-oxidation;Fermentation;
 Language
Korean
 Cited by
1.
고지방식이로 유도한 신장의 산화적 스트레스에 대한 자화지정(紫花地丁)의 항산화 효과,최미혜;박인식;

동의생리병리학회지, 2016. vol.30. 4, pp.250-256 crossref(new window)
 References
1.
Aebi, H.: Catalase in vitro, In: Packer L, ed methods in Enzymology. N. Y. Academic, 105, 121-126 (1984).

2.
Arellano-gonzalez, M. A., Ramirez-coronel, M. A., Torresmancera, M. T., Perez-morales, G. G. and Saucedo-castaneda, G.: Antioxidant Activity of Fermented and Nonfermented Coffee (Coffea arabica) Pulp Extracts. Food Technol. Biotechnol, 49, 374-378 (2011).

3.
Beauchamp, C. and Fridovich, I.: Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Analytical biochemistry, 44, 276-287 (1971). crossref(new window)

4.
Blois, M.S.: Antioxidant determination by the use of a stable free radical. Nature, 26, 1199-1200 (1958).

5.
Carillon, J., Romain, C., Bardy, G., Fouret, G., Feilletcoudray, C., Gaillet, S., Lacan, D., Cristol, J. and Rouanet, J.: Cafeteria diet induces obesity and insulin resistance associated with oxidative stress but not with inflammation: improvement by dietary supplementation with a melon superoxide dismutase. Free Radical Biology and Medicine, 65, 254-261 (2013). crossref(new window)

6.
Choi, S. H.: Pharmacological and Molecular studies of Atracylodes japonica Koidzumi on anti-oxidant activity, M. S. Thesis, KyungHee University, 1-29 (2011).

7.
Doh, E.S., Chang, J.P., Kil, K.J., Choi, M.S., Yang, J.K., Yun, C.W., Jeong, S.M., Jung, Y.H., Lee, G.H.: Antioxidative Activity and Cytotoxicity of Fermented Allium victorialis L. Extract. Korean J. Plant Res., 24., 30-39 (2011). crossref(new window)

8.
Dordevic, T. M., Siler-Marinkovic, S. S. and Dimitrifevicbrankovic, S. I.: Effect of fermentation on antioxidant properties of some cereals and pseudo cereals. Food Chemistry, 119, 957-963 (2010). crossref(new window)

9.
Folin, A.D. and Denis, W.: A colorimetric method for the determination of phenols (and phenolderivatives) in urine. J. Biol. Chem., 22, 305-308 (1915).

10.
Ha, B.J. and KIm, M.H.: Effect of Chondroitin Sulfate on Collagen Maturity and Aging. J. Food Hygiene and Safety, 14, 45-54 (1999).

11.
Ha, B.J., Kim, H.J., Lee, S.H., Ha, J.M., Lee, S.H., Lee, J.H., Lee, D.G., Park, E.K. and Nam, C.S.: The Hepatoprotective Effects of Epimedii Herba through the Antioxidation. J. of Life Sci., 15, 572-577 (2005). crossref(new window)

12.
Ha, B.J.: Effects of Rhynchosia molubilis Saponin on Hepatotoxicity and Pathology. J. of Life Sci., 16, 186-191 (2006). crossref(new window)

13.
Ha. B. J.: Studies on the Antilipidperoxidation effect of Brazilin and Hematoxylin. Ph. D. Dissertation. Seoul university, Seoul, Korea (1985).

14.
Hong, J.Y., Shin, S.R., Kong, H.J., Choi, E.M., Woo, S.C., Lee, M.H. and Yang, K. M.: Antioxidant activity of extracts from soybean and small black bean. Korean J. Food Preserv., 21, 404-411 (2014). crossref(new window)

15.
Kang, M.H., Lee, J.H., Lee, J.S., Kim, J.H., Chung, H.K.: Effects of Acorn Supplementation on Lipod Profiles and Antioxidant Enzyme Acticities in High Fat Diet-Induced Obese Rats. Korean J. of nutrition, 37, 169-175 (2004).

16.
Kang, S.A. and Han, J.A.: Acetycholinesterase Inhibiting Effect and Free Radical Scavenging Effect of Soybean(Glycine max) and Yak-Kong(Rhychosia nolubilis)*. J. East Asian Soc. Dietary Life, 14, 64-69 (2004).

17.
Kim, H.J., Lee, S.G., Park, S.J., Yu, M.H., Lee, E.J., Lee, S.P., Lee, I.S.: Antioxidant Effects of Extracts from Fermented Red Ginseng Added with Medicinal Herbs in STZinduced Diabetic Rats. Korean J. Food Sci. Technol, 44, 367- 372 (2012). crossref(new window)

18.
Kim, J. D., Lee, B. I., Jeon, Y. H., Bak, J. P., Jin, H. L. and Lim, B. O.: Anti-Oxidative and Anti-Inflammatory Effects of Green Tea Mixture and Dietary Fiber on Liver of High Fat Diet-Induced Obese Rats. Korean J. Medicinal Crop Sci., 18, 224-230 (2010).

19.
Kim, J. Y., Shin, M., Heo, Y. R.: Effects of Stabilized Rice Bran on Obesity and Antioxidative Enzyme Activity in High Fat Diet-induced Obese C57BL/6 Mice. J. Korean Soc. Food Sci. Nutr., 43, 1148-1157 (2014). crossref(new window)

20.
Kim, Y.H., Lee, Y.J., Park, S.O., Lee, S.J., Lee, O.H.: Antioxidant Compounds and Antioxidant Activities of Fermented Black Rice and Its Fractions. Korean J. Food Sci. Technol, 45, 262-266 (2013). crossref(new window)

21.
Kobayashi, M.M., Fujita, H. and Mitsuhashi.: Components of Cnidium officinale Makino: occurrence of pregnenolone, coniferylferulate, ferulate and hydroxylprthalides. Cham Pharm. Bull. 23, 3770-3773 (1984).

22.
Kwon, C.S.: Antioxidant Properties of Red Yeast Rice (Monascus purpureus) Extracts. J. Korean Soc. Food Sci. Nutr., 41, 437-442 (2012). crossref(new window)

23.
Park, H.J., Nam, J.H., Jung, H.J., Lee, M.S., Lee, K.T., Jung, M.H., Choi, J.W.: Inhibitory Effect of Euscaphic Acid and Tormentic Acid from the Roots of Rosa rugosa on High Fat Diet-Induced Obesity in the Rat. Korea J. Pharmacogn, 36, 324-331 (2005).

24.
Park, J.W., Lee, Y.J. and Yoon, S.: Total flavonoids and phenolics in fermented soy products and their effects on antioxidant activities determined by different assays. Korean J. Food Culture, 22, 353-358 (2007).

25.
Ryu, B.H., Park, J.O., Kim, H.S. and Lim, B.G.: Activity of Superoxide dismutase(SOD) by fermented soybean. Korean J. Life Science, 11, 574-581 (2001).

26.
Shin, M.K. and Han, S.H.: Effects of Methanol Extracts from Rhynchosia nulubilis on serum Lipid Concentractions in Rats fed High Fat and High Cholesterol Diet. Korean J. Dietary Culture. 17, 64-69 (2002).

27.
Sim, Y.S.: Effects of Paeonia suffruticosa Extract on Antioxidation and Activation of Caspase on Human Lung Cancer cell A549. M. S. Thesis, Dongguk University, 1-39 (2015).

28.
Sung, K.S. Chun, C., Kwon, Y.H., Kim, K.H. and Chang, C.C.: Effects of Red Component on the Antioxidative Enzymes Activities and Lipid Peroxidation in the Liver of Mice. J. Ginseng Res., 24, 29-34 (2000).