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Anti-Obesity Effects of Foeniculum fructus Water Extract
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 Title & Authors
Anti-Obesity Effects of Foeniculum fructus Water Extract
Seo, Dong-Joo; Kim, Jeong-Mi; Kim, Tae-Hyuk; Baek, Jong-Mi; Kim, Tae-Woo; Kim, Hyun-Sook; Choe, Myeon;
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We investigated the anti-obesity effects of Foeniculum fructus water extract on body weight, epididymal adipocyte size, plasma lipid levels and activities of key enzymes such as lipoprotein lipase (LPL), acyl-CoA synthetase (ACS) in high fat diet-induced obese mice. Experimental groups were normal diet group (ND), high fat diet group (HFD), high fat diet with 0.05% orlistat group (HFDO), and high fat diet with 0.5% Foeniculum fructus group (HFDF). Eleven-weeks feeding with HFD resulted in significant increase in lipid levels, body weight, liver and epididymal adipose tissue weight, compared with the ND group. Diet containing Foeniculum fructus water extract significantly reduced plasma total cholesterol, triglyceride and glucose concentrations as well as body weight, liver and epididymal adipose tissue weights. Plasma LDL cholesterol levels were significantly lower in the HFDF group than those in HFDO group. LPL activities elevated by a high fat diet were significantly decreased by Foeniculum fructus water extract administration. ACS activities decreased in the high fat diet group and markedly increased in the Foeniculum fructus water extract administered group. All things considered, Foeniculum fructus water extract efficiently inhibits the inflow of fatty acid into the cell, and activates metabolic process that uses fatty acids flowing as an energy source. Thus, Foeniculum fructus water extract may have great potential as a novel anti-obesity agent.
obesity;Foeniculum fructus;adipocyte;lipoprotein lipase;acyl-CoA synthetase;
 Cited by
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Albu J, Allison D, Boozer CN, Heymsfield S, Kissileff H, Kretser A, Krumhar K, Leibei R, Nonas C, Pi-Sunyer X, Vanltallie T, Wedral E. 1997. Obesity solutions: report of a meeting. Nutr Res 55: 150-156.

Grundy SM. 1998. Multifactorial causation of obesity: implications for prevention. Am J Clin Nutr 67: 563S-572S. crossref(new window)

Naderali EK. 2009. Obesity and cardiovascular dysfunction: A role for resveratrol? Obes Res Clin Prac 3: 45-52. crossref(new window)

Kim YS. 2001. The update of anti-obesity drug. Kor Endocrine Soc 16: 9-15.

Park HS. 2001. Pharmacological therapy of obesity. Kor J Soc Study Obes 10: 118-127.

Ballinger A, Peikin SR. 2002. Orlistat: its current status as an anti-obesity drug. Eur J Pharmacol 440: 109-117. crossref(new window)

Zacour AC, Sliva ME, Cecon PR, Bambirra EA, Vieira EC. 1992. Effect of dietary chitin on cholesterol absorption and metabolism in rats. J Nutr Sci Vitaminol 38: 609-613. crossref(new window)

Burns AA, Livingstone MB, Welch RW, Dunne A, Rowland IR. 2002. Dose response effects of a novel fat emulsion (Oliibra) on energy and macronutrient intakes up to 36 h post-consumption. Eur J Clin Nutr 56: 368-377. crossref(new window)

Kim YJ, Kim BH, Lee SY, Kim MS, Park CS, Rhee MS, Lee KH, Kim DS. 2006. Screening of medicinal plants for development of functional food ingredients with antiobesity. J Korean Soc Appl Biol Chem 49: 221-226.

Kim YS, Byun SH, Kim SC, Kum M, Cho EH. 2000. Effect on cure and prevention of an obesity. Kor J Herbology 15: 37-43.

Jeon JR, Kim JY, Lee KM, Cho DH. 2005. Anti-obese effects of mixture contained pine needle, black tea and green tea extracts. J Korean Soc Appl Biol Chem 48: 375-381.

Oktay M, Gulcin I, Kufrevioglu OI. 2003. Determination of vitro anti-oxidant activity of funnel (Foeniculum vulgare) seed extracts. Lebensm Wiss Technol 36: 263-271. crossref(new window)

Choi EM, Koo SJ. 2004. Inhibition of lipopolysaccharide-stimulated inflammatory mediator production in RAW264.7 macrophages by Foeniculum vulgare fruit extract. Korean J Soc Food Cookery Sci 20: 505-510.

Hwang HY, Choi YS, Jung BH, Lim BW, Kim JD. 2007. Effect of Foeniculum vulgare Gaertner extracts on blood pressure in spontaneously hypertensive rats. Proceedings of the Korean Society of Medical Crop Science. p 161-162.

Lee HS, Mun HC, Park JH, Kim DH, Yoo JE, Park YS, Ryu LH, Choi KP, Lee HY. 2003. Comparison of biological activities of essential oils from Foeniculum vulgare Mill, Boswellia carteli Birew and J uniperus rigida Sieb, by a supercritial fluid extraction system. Korean J Medicinal Crop Sci 11: 115-121.

Lee JC, Lee E, Lee YC, Oh H, Yoon HS, Ha TK, Hong EH. 2007. Effects of Fructus foeniculi extract on recovering liver function. Kor J Herbology 22: 213-218.

Farooq A, Muhammad A, Abdullah I, Muahmmad S. 2009. Antioxidant and antimicrobial activities of essential oil and extracts of fennel (Foeniculum vulgare Mill.) seeds from Pakistan. Favour Fragr J 24: 170-176. crossref(new window)

Choe M, Kim DJ, Lee HJ, You JK, Seo DJ, Lee JH, Chung MJ. 2008. A study on the glucose-regulating enzymes and antioxidant activities of water extracts from medicinal herbs. J Korean Soc Food Sci Nutr 37: 542-547. crossref(new window)

Ryu JM, Lee TH, Seo IK, Lee SH, Jang YH, Kim YB, Wang SY. 2006. Anti-obesity effects of Misaengtang in rats fed on a high-fat diet or normal diet. Toxicol Res 22: 339-348.

Singh B, Kale RK. 2008. Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system. Food Chem Toxicol 46: 3842-3850 crossref(new window)

Friedewald WT, Levy RI, Fredrick DS. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.

Seo DJ, Chung MJ, Kim DJ, Choe M. 2009. Antiobese effects of diet containing medicinal plant water extracts in high fat diet-induced obese mice. J Korean Soc Food Sci Nutr 38: 1522-1527. crossref(new window)

Lee JJ, Chung CS, Kim JG, Choi BD. 2000. Effects of fasting-refeeding on rat adipose tissue lipoprotein lipase activity and lipogenesis: influence of food restriction during refeeding. J Korean Soc Food Sci Nutr 29: 471-478.

Mela DJ, Cohen RS, Kris-Etherton PM. 1987. Lipoprotein metabolism in a rat model of diet-induced adiposity. Am J Nutr 117: 1655-1662. crossref(new window)

Quinn DM, Shirai K, Jackson RL, Harmony JK. 1982. Lipoprotein lipase catalyzed hydrolysis of water-soluble p-nitrophenyl esters inhibition by apolipoprotein C-I. Am J Biochem 21: 6872-6879. crossref(new window)

Shirai K, Jackson RL. 1982. Lipoprotein lipase-catalyzed hydolysis of p-nitrophenyl butyrate. J Biochem 257: 1253-1258.

Shimizu S, Inoue K, Tani Y, Yamada H. 1979. Enzymatic microdetermination of serum free fatty acids. Anal Biochem 98: 341-344. crossref(new window)

Jayasooriya AP, Sakono M, Yukizaki C, Kawano M, Yamamoto K, Fukuda N. 2000. Effects of Momordica charantia powder on serum glucose levels and various lipid parameters in rats fed with cholesterol-free and cholesterol enriched diets. J Ethnopharmacol 72: 331-336. crossref(new window)

Lee JJ, Shin HD, Lee YM, Kim AR, Lee MY. 2009. Effect of broccoli sprouts on cholesterol-lowering and anti-obesity effects in rats fed high fat diet. J Korean Soc Food Sci Nutr 38: 309-318. crossref(new window)

Park YS, Yoon Y, Ahn HS. 2007. Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats. World J Gastroenterol 13: 3493-3499. crossref(new window)

Kim HS, Kim TW, Kim DJ, Hwang HJ, Lee HJ, Choe M. 2007. Effects of natural plants supplementation on adipocyte size of the epididymal fat pads in rats. J Korean Soc Food Sci Nutr 36: 419-423. crossref(new window)

Shin JH, Lee SJ, Sung NJ. 2002. Effects of Zingiber mioga, Zingiber mioga root and Zingiber officinale on the lipid concentration in hyperlipidemic rats. J Korean Soc Food Sci Nutr 31: 679-684. crossref(new window)

Kang SA, Jang KH, Park SK, Lim JP, Jeon H, Cui X, Leem KH. 2003. Effects of herbal composition on obese rats fed high fat diet. Kor J Herbology 18: 59-64.

Cho YS, Shon MY, Lee MK. 2007. Lipid-lowering action of powder and water extract of mulberry leaves in C57BL/6 mice fed high-fat diet. J Korean Soc Food Sci Nutr 36: 405-410. crossref(new window)

Lee HJ, Chung MJ, Kim DJ, Choe M. 2009. Effects of Oenanthe J avanica, Coicis lachryma-jobi L. var., and Plantaginis asiatica L. water extracts on activities of key enzymes on lipid metabolism. J Korean Soc Food Sci Nutr 38: 1516-1521. crossref(new window)

Park SH, Ko SK, Chung SH. 2005. Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice. J Ethnopharmacol 102: 326-335. crossref(new window)

Wat E, Tandy S, Kapera E, Kamili A, Chung RWS, Brown A, Rowney M, Cohn JS. 2009. Dietary phospholipid-rich dairy milk extract reduces hepatomegaly, hepatic steatosis and hyperlipidemia in mice fed a high-fat diet. Atherosclerosis 205: 144-150. crossref(new window)

Park HS, Lee YS, Choi SJ, Kim JK, Lee YL, Kim HG, Koo SH, Ku DH, Ki SI, Lim SS. 2009. Effects of herbal complex on blood glucose in streptozotocin-induced diabetic rats and in mice model of metabolic syndrome. Kor J Pharmacogn 40: 196-204.

Moon GA, Choi SM, Kim SH, Kim SS, Kang JY, Yoon Y. 2003. Human and animal study on the natural food for obesity and metabolic syndrome risk factors. J Korean Soc Food Sci Nutr 32: 1394-1400. crossref(new window)

Lee JJ, Choe MS, Chung CS, Choe B. 2003. Effect of food restriction on rat adipotise tissue lipoprotein lipase activity and lipogenesis. Kor J Exercise Nutr 7: 135-141.

Sememkovich CF, Colemen T, Daugherty A. 1998. Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice. J Lipid Res 39: 1411-1488.

Chiu KM, Schmidt MJ, Shug AL, Binkley N, Gravenstein S. 1997. Effect of dehydroepiandrosterone sulfate on carnitine acetyl transferase activity and L-carnitine levels in oophorectomized rats. Biochim Biophys Acta 1344: 201-209. crossref(new window)

Ryu MH, Daily JW, Cha YS. 2005. Effect of starvation on hepatic acyl-CoA synthetase, carnitine palmitoyltransferase-I, and acetyl-CoA carboxylase mRNA levels in rats. Nutrition 21: 537-542. crossref(new window)