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Anti-Obesity Effects of Foeniculum fructus Water Extract
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 Title & Authors
Anti-Obesity Effects of Foeniculum fructus Water Extract
Seo, Dong-Joo; Kim, Jeong-Mi; Kim, Tae-Hyuk; Baek, Jong-Mi; Kim, Tae-Woo; Kim, Hyun-Sook; Choe, Myeon;
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 Abstract
We investigated the anti-obesity effects of Foeniculum fructus water extract on body weight, epididymal adipocyte size, plasma lipid levels and activities of key enzymes such as lipoprotein lipase (LPL), acyl-CoA synthetase (ACS) in high fat diet-induced obese mice. Experimental groups were normal diet group (ND), high fat diet group (HFD), high fat diet with 0.05% orlistat group (HFDO), and high fat diet with 0.5% Foeniculum fructus group (HFDF). Eleven-weeks feeding with HFD resulted in significant increase in lipid levels, body weight, liver and epididymal adipose tissue weight, compared with the ND group. Diet containing Foeniculum fructus water extract significantly reduced plasma total cholesterol, triglyceride and glucose concentrations as well as body weight, liver and epididymal adipose tissue weights. Plasma LDL cholesterol levels were significantly lower in the HFDF group than those in HFDO group. LPL activities elevated by a high fat diet were significantly decreased by Foeniculum fructus water extract administration. ACS activities decreased in the high fat diet group and markedly increased in the Foeniculum fructus water extract administered group. All things considered, Foeniculum fructus water extract efficiently inhibits the inflow of fatty acid into the cell, and activates metabolic process that uses fatty acids flowing as an energy source. Thus, Foeniculum fructus water extract may have great potential as a novel anti-obesity agent.
 Keywords
obesity;Foeniculum fructus;adipocyte;lipoprotein lipase;acyl-CoA synthetase;
 Language
Korean
 Cited by
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백모근(白茅根) 청피(靑皮) 오수유(吳茱萸) 복합방(複合方)(YY312)의 고지방식이로 유도된 마우스와 3T3-L1 세포에서 항비만 효과,강인숙;황근영;최아영;노국환;최지현;심여문;박유경;오명숙;

대한본초학회지, 2013. vol.28. 1, pp.23-31 crossref(new window)
2.
어린 으름잎 추출물(Akebia quinata D. Leaves)의 항비만 효과,전용섭;유양희;전우진;

한국식품영양과학회지, 2014. vol.43. 2, pp.200-206 crossref(new window)
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항비만소재의 lipoprotein lipase 억제 작용 연구,이성미;강윤환;김경곤;김태우;최면;

한국식품과학회지, 2015. vol.47. 2, pp.246-253 crossref(new window)
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Comparative study of three herbal medicine formulas on high fat diet-induced obese mice, Proceedings of the Nutrition Society, 2011, 70, OCE4  crossref(new windwow)
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Anti-obesity effects of herbal extract YY312 in C57BL/6 mice fed a high-fat diet and 3T3-L1 cells, The Korea Journal of Herbology, 2013, 28, 1, 23  crossref(new windwow)
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Anti-obesity Effects of Extracts from Young Akebia quinata D. Leaves, Journal of the Korean Society of Food Science and Nutrition, 2014, 43, 2, 200  crossref(new windwow)
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Study of Lipoprotein Lipase Inhibitory Activity of Anti-obesity Herb Extracts, Korean Journal of Food Science and Technology, 2015, 47, 2, 246  crossref(new windwow)
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