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Anti-diabetic and Hypoglycemic Effect of Eleutherococcus spp.
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 Title & Authors
Anti-diabetic and Hypoglycemic Effect of Eleutherococcus spp.
Lim, Sang-Hyun; Park, Yu-Hwa; Kwon, Chang-Ju; Ham, Hun-Ju; Jeong, Haet-Nim; Kim, Kyung-Hee; Ahn, Young-Sup;
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 Abstract
Hypoglycemic effect through activity inhibition of -glucosidase and -amylase was evaluated using leaves of Eleutherococcus senticosu, Eleutherococcus gracilistylus, Eleutherococcus sieboldianus and Eleutherococcus sessiliflorus which belong to Acanthopanax sessiliflorus genus. As a result of measuring -glucosidase activity inhibition, extract of Eleutherococcus gracilistylus showed around 43.38% of activity inhibition compared with acarbose and extract of Eleutherococcus senticosu showed 41.24% inhibitory effect. As a result of measuring -amylase activity inhibition, acarbose showed 73.25% of activity inhibition in 10 mg/mL concentration, and the extract of Eleutherococcus senticosu leaves showed 91.90% higher activity inhibition compared with acarbose. Also, after subjects in a model were induced diabetes with streptozotocin (STZ) intake plant extract from Acanthopanax sessiliflorus for 2 weeks, effect of improving blood glucose level and fat was examined. In all groups with specimen, Eleutherococcus senticosu (T1), Eleutherococcus gracilistylus (T2), Eleutherococcus sieboldianus (T3) and Eleutherococcus sessiliflorus (T4), blood glucose level was significantly decreased compared with that in control group (C). In an experiment of examining changes in fat concentration in blood, total cholesterol content increased in a control group compared with a normal, while in T1, T3 and T4, it decreased significantly compared with the control group. As for HDL-cholesterol, it significantly increased in all diabetes induced groups compared with the normal group, and in T3, it increased the most significantly by 55.61% compared with the control group. In case of LDL-cholesterol, specific difference between the normal group and the control group was not found; however, significant increase was detected in T2 and T3, whereas in T1 and T4, it decreased significantly compared with the control group. As for triglyceride, its concentration increased in the control group like total cholesterol. It decreased 60.16% in T3, 60.80% in T4 and 50.16% in T1 compared with the control group. As a result of measuring the concentration of triglyceride in extracted liver, the control group showed significant increase compared with the normal group, whereas T1 and T2 showed significant decrease compared with the normal group. The above results show that extracts from Acanthopanax sessiliflorus genus are effective for hypoglycemic and improving fat metabolism due to diabetes.
 Keywords
Eleutherococcus senticosu;Eleutherococcus gracilistylus;Eleutherococcus sieboldianus;Eleutherococcus sessiliflorus; -glucosidase;-amylase;anti-diabetic;streptozotocin;
 Language
Korean
 Cited by
1.
신령버섯균사체 액체배양물의 α-glucosidase 저해 효과,정관주;문연규;권정민;안채린;김정옥;하영래;

생명과학회지, 2011. vol.21. 11, pp.1579-1585 crossref(new window)
2.
오가피(Acanthopanax sessiliflorus Seeman) 열매로부터 분리한 페놀 화합물의 항산화활성,인서지;이대영;서경화;남태규;김대옥;김금숙;노형준;김계원;서우덕;강희철;백남인;

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지골피, 산수유의 streptozotocin 유발 당뇨흰쥐에서의 효과 비교 연구,한윤경;박용기;

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반응표면분석을 이용한 오가자, 오디, 복분자 및 녹차의 항산화 활성 추출 최적화,이지혜;김양;이수용;유상호;

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감마선 조사한 총목피(Aralia elata Cortex) 추출물의 생리활성,박혜진;이은호;김명욱;이선호;안동현;안봉전;권중호;조영제;

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가시오갈피(Eleutherococcus senticosus) 잎으로부터 α-Glucosidase의 저해 활성 물질, Hyperoside와 Isoquercetin의 분리 및 구조·동정,이기연;홍수영;정혜정;이재형;임상현;허남기;김성문;김희연;

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한국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(IX),최소진;김영숙;김주환;김진숙;

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8.
nrDNA ITS 및 엽록체 DNA 염기서열 분석에 의한 유통 한약재 오가피 판별,김정훈;변지희;박효섭;이정훈;이상원;차선우;조준형;

한국약용작물학회지, 2015. vol.23. 6, pp.489-499 crossref(new window)
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