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Effects of Agaricus blazei Murill Water Extract on Immune Response in BALB/c Mice
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 Title & Authors
Effects of Agaricus blazei Murill Water Extract on Immune Response in BALB/c Mice
Kang, In Soon; Kim, Rang Ie; Kim, Gwang Sub; Kim, Na Ri; Shin, Joong Yup; Kim, Chaekyun;
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The edible mushroom Agaricus blazei Murill is known to have many physiological functions, including antitumor, antiviral, and anti-inflammatory effects. Aqueous extracts were obtained by extracting A. blazei in water at for 15 h, followed by spray-drying with dextran at a 70:30 ratio. In this study, we examined the immunomodulatory effect of A. blazei Murill water extract (ABM) in BALB/c mice. Mice were administered orally with 4, 20, and 100 mg/kg of ABM for 21 days. ABM-treated mice did not show significant differences in body and organ weights compare to saline-treated control mice. Splenocytes isolated from ABM-administered mice revealed similar levels of cellularity and proliferation compared to control mice, whereas they showed increased natural killer (NK) cell activity and decreased IL-4 and IL-12 production. Different from in vivo results, splenocytes isolated from normal mice showed increased proliferation and production following ABM treatment in vitro. In addition, ABM treatment enhanced macrophage proliferation and nitric oxide (NO) production in a dose-dependent manner. However, ABM had no effect on LPS-induced NO production. These results suggest that A. blazei modulates immune function by increasing NK cell activity and macrophage function.
Agaricus blazei Murill;splenocytes;natural killer cell;macrophage;nitric oxide;
 Cited by
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