Advanced SearchSearch Tips
Anti-Diabetic, Alcohol Metabolizing Enzyme, and Hepatoprotective Activity of Acer tegmentosum Maxim. Stem Extracts
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Anti-Diabetic, Alcohol Metabolizing Enzyme, and Hepatoprotective Activity of Acer tegmentosum Maxim. Stem Extracts
Cho, Eun Kyung; Jung, Kyung Im; Choi, Young Ju;
  PDF(new window)
This study was carried out to investigate the antidiabetic, alcohol metabolism, anti-inflammatory, and hepatoprotective effects of Acer tegmentosum extracts (ATE). A. tegmentosum has been traditionally used as a folk medicine to treat hepatic disorders. The antioxidative activities of ATE were measured by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and superoxide (SOD) assay. DPPH radical scavenging and SOD activities of ATE were about 89% and 82.9% at , respectively. Alcohol dehydrogenase and acetaldehyde dehydrogenase activities were 118.0% and 177% at 2 mg/mL, respectively. inhibitory activity of ATE was 75% higher at and remarkably increased in a dose-dependent manner. Nitric oxide productions in macrophage RAW 264.7 cells stimulated by lipopolysaccharide was reduced to 16.7% by addition of ATE at 1 mg/mL. ATE showed significant protective effects against tacrine-induced cytotoxicity in Hep G2 cells at . Based on our results, we conclude that ATE may be used as a major pharmacological agent and anti-diabetic, anti-hepatitis, and anti-inflammatory remedy.
Acer tegmentosum;anti-inflammatory;;alcohol dehydrogenase;hepatoprotective;
 Cited by
Hong BK, Eom SH, Lee CO, Lee JW, Jeong JH, Kim JK, Cho DH, Yu CY, Kwon YS, Kim MJ. 2007. Biological activities and bioactive compounds in the extract of Acer tegmentosum Maxim. stem. Korean J Medicinal Crop Sci 15: 296-303.

Shin IC, Sa JH, Shim TH, Lee J. 2006. The physical and chemical properties and cytotoxic effects of Acer tegmentosum Maxim. extracts. J Korean Soc Appl Biol Chem 49: 322-327.

Kwon DJ, Kim JK, Bae YS. 2011. DPPH radical scavenging activity of phenolic compounds isolated from the stem wood of Acer tegmentosum. Mokchae Konghak 39: 104-112.

Hur JM, Jun M, Yang EJ, Choi SH, Park JC, Song KS. 2007. Isolation of isoprenoidal compounds from the stems of Acer tegmentosum Max. Kor J Pharmacogn 38: 67-70.

Hur JM, Yang EJ, Choi SH, Song KS. 2006. Isolation of phenolic glucosides from the stems of Acer tegmentosum Max. J Korean Soc Appl Biol Chem 49: 149-152.

Won SJ, Park HJ, Lee KT. 2008. Inhibition of LPS induced iNOS, COX-2 and cytokines expression by salidroside through the NF-${\kappa}B$ inactivation in RAW 264.7 cells. Kor J Pharmacogn 39: 110-117.

Kwon HN, Park JR, Jeon JR. 2008. Antioxidative and hepatoprotective effects of Acer tegmentosum M. extracts. J Korean Soc Food Sci Nutr 37: 1389-1394. crossref(new window)

Kim SH, Park HJ, Cho JW. 2008. Hepatoprotective activity of salidroside isolated from Acer termentosum Max on Dgalactosamine induced hepatotoxicity in rats. Korean J Oriental Physiol 22: 1525-1531.

Lee S, Woo H. 2010. A study of the inhibitory effect of Acer tegmentosum Max. on fibrogenesis in hepatic stellate cell line T6. Korean J Orient Int Med 31: 346-355.

Seo Y, Bazarsad D, Choe SY. 2012. Effect of Acer tegmentosum Maxim. extracts on acute hepatitis and fatty liver in rats. J Biomed Res 13: 165-170. crossref(new window)

Hwang YH, Park H, Ma JY. 2013. In vitro and in vivo safety evaluation of Acer tegmentosum. J Ethnopharmacol 148: 99-105. crossref(new window)

Ha H, Shim KS, Kim T, An H, Lee CJ, Lee KJ, Ma JY. 2014. Water extract of Acer tegmentosum reduces bone destruction by inhibiting osteoclast differentiation and function. Molecules 19: 3940-3954. crossref(new window)

Seo HW, Park KJ, Guahk GH, Im JS, Kim DK, Leem JY, Cha DS, Kwon J, Oh CH, Jeon H. 2013. Anti-nociceptive activity of Acer tegmentosum MeOH extract. Kor J Pharmacogn 44: 188-192.

Liu Q, Shin E, Ahn MJ, Hwang BY, Lee MK. 2011. Antiadipogenic activity of Acer tegmentosum and its constituent, catechin in 3T3-L1 cells. Natural Product Sci 17: 212-215.

Yu T, Lee J, Lee YG, Byeon SE, Kim MH, Sohn EH, Lee YJ, Lee SG, Cho JY. 2010. In vitro and in vivo anti-inflammatory effects of ethanol extract from Acer tegmentosum. J Ethnopharmacol 128: 139-147. crossref(new window)

Kim S, Hur SJ, Kim KH, Gi KS, Whang WK. 2012. Antioxidant and anti-inflammatory compounds isolated from Acer tegmentosum. J Med Plants Res 6: 3971-3976.

Choi JH, Lee SH, Park YH, Lee SG, Jung YT, Lee IS, Park JH, Kim HJ. 2013. Antioxidant and alcohol degradation activities of extracts from Acer tegmentosum Maxim. J Korean Soc Food Sci Nutr 42: 378-383. crossref(new window)

Singleton VL, Orthofer R, Lamuela-Raventos RM. 1999. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 299: 152-178. crossref(new window)

Chu CJ, Hsiao CC, Wang TF, Chan CY, Lee FY, Chang FY, Chen YC, Huang HC, Wang SS, Lee SD. 2005. Prostacyclin inhibition by indomethacin aggravates hepatic damage and encephalopathy in rats with thioacetamide-induced fulminant hepatic failure. World J Gastroenterol 11: 232-236. crossref(new window)

Yun HY, Dawson VL, Dawson TM. 1996. Neurobiology of nitric oxide. Crit Rev Neurobiol 10: 291-316. crossref(new window)

Weisz A, Cicatiello L, Esumi H. 1996. Regulation of the mouse inducible-type nitric oxide synthase gene promoter by interferon-$\gamma$, bacterial lipopolysaccharide and $N^G$-monomethyl-L-arginine. Biochem J 316: 209-215. crossref(new window)

Byun E, Jeong GS, An RB, Li B, Lee DS, Ko EK, Yoon KH, Kim YC. 2007. Hepatoprotective compound of Cassiae Semen on tacrine-induced cytotoxicity in Hep G2 cells. Kor J Pharmacogn 38: 400-402.

Watkins PB, Zimmerman HJ, Knapp MJ, Gracon SI, Lewis KW. 1994. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. J Am Med Assoc 271: 992-998. crossref(new window)

Blois MS. 1958. Antioxidant determinations by the use of a stable free radical. Nature 181: 1199-1200. crossref(new window)

Tibbot BK, Skadsen RW. 1996. Molecular cloning and characterization of a gibberellin-inducible, putative alpha-glucosidase gene from barley. Plant Mol Biol 30: 229-241. crossref(new window)

Choi JT, Joo HK, Lee SK. 1995. The effect of Schizandra fructus extract on alcohol fermentation and enzyme activities of Saccharomyces cerevisiae. Agric Chem Biotechnol 38: 278-282.

Racker E. 1955. Alcohol dehydrogenase from baker's yeast. Methods of Enzymology 1: 500-506. crossref(new window)

Koivula T, Koivusalo M. 1975. Different forms of rat liver aldehyde dehydrogenase and their subcellular distribution. Biochim Biophys Acta 397: 9-23. crossref(new window)

Marletta MA. 1993. Nitric oxide synthase structure and mechanism. J Biol Chem 268: 12231-12234.

Choi SY, Lin SH, Kim JS, Ha TY, Kim SR, Kang KS, Hwang IK. 2005. Evaluation of the estrogenic and antioxidant activity of some edible and medicinal plant. Korean J Food Sci Technol 37: 549-556.

Jung YT, Lee IS, Whang K, Yu MH. 2012. Antioxidant effects of Picrasma quassioides and Chamaecyparis obtusa (S. et Z.) ENDL extracts. J Life Sci 22: 354-359. crossref(new window)

Jeong HJ, Lee SG, Lee EJ, Park W, Kim JB, Kim HJ. 2010. Antioxidant activity and anti-hyperglycemic activity of medicinal herbal extracts according to extraction methods. Korean J Food Sci Technol 42: 571-577.

Maisuthisakul P, Suttajit M, Pongsawatmanit R. 2007. Assessment of phenolic content and free radical-scavenging capacity of some Thai indigenous plants. Food Chem 100: 1409-1418. crossref(new window)

Matsukawa R, Dubinsky Z, Kishimoto E, Masaki K, Masuda Y, Takeuchi T, Chihara M, Yamamoto Y, Niki E, Karube I. 1997. A comparison of screening methods for antioxidant activity in seaweeds. J Appl Phycol 9: 29-35. crossref(new window)

Kim EY, Bai IH, Kim JH, Kim SR, Rhyu MR. 2004. Screening of the antioxidant activity of some medicinal plants. Korean J Food Sci Technol 36: 333-338.

Kim SH, Choi DS, Athukorala Y, Jeon YJ, Senevirathne M, Rha CK. 2007. Antioxidant activity of sulfated polysaccharides isolated from Sargassum fulvellum. J Food Sci Nutr 12: 63-73.

Heo SJ, Park EJ, Lee KW, Jeon YJ. 2005. Antioxidant activities of enzymatic extracts from brown seaweeds. Bioresource Technol 96: 1613-1623. crossref(new window)

Cho EK, Kang SH, Choi YJ. 2013. Biological analysis of enzymatic extracts from Sargassum fulvellum using polysaccharide degrading enzyme. KSBB J 28: 349-355. crossref(new window)

Moller DE. 2001. New drug targets for type 2 diabetes and the metabolic syndrome. Nature 414: 821-827. crossref(new window)

Lee EH, Ham J, Ahn HR, Kim MC, Kim CY, Pan CH, Um BH, Jung SH. 2009. Inhibitory effects of the compound isolated from Sargassum yezoense on $\alpha$-glucosidase and oxidative stress. Kor J Pharmacogn 40: 150-154.

Shinde J, Taldone T, Barletta M, Kunaparaju N, Hu B, Kumar S, Placido J, Zito SW. 2008. $\alpha$-Glucosidase inhibitory activity of Syzygium cumini (Linn.) Skeels seed kernel in vitro and in Goto-Kakizaki (GK) rats. Carbohydr Res 343: 1278-1281. crossref(new window)

Lee KS, Kim GH, Seong BJ, Kim HH, Kim MY, Kim MR. 2009. Effects of aqueous medicinal herb extracts and aqueous fermented extracts on alcohol-metabolizing enzyme activities. Korean J Food Preserv 16: 259-265.

Cha JY, Jeong JJ, Yang HJ, Lee BJ, Cho YS. 2011. Effect of fermented sea tangle on the alcohol dehydrogenase and acetaldehyde dehydrogenase in Saccharomyces cerevisiae. J Microbiol Biotechnol 21: 791-795. crossref(new window)

Lugnier C, Keravis T, Eckly-Michel A. 1999. Cross talk between NO and cyclic nucleotide phosphodiesterases in the modulation of signal transduction in blood vessel. J Physiol Pharmacol 50: 639-652.

Moncada S, Palmer RM, Higgs EA. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142.