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Anti-Inflammatory Activities of Extracts from Fermented Taraxacum platycarpum D. Leaves Using Hericium erinaceum Mycelia
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 Title & Authors
Anti-Inflammatory Activities of Extracts from Fermented Taraxacum platycarpum D. Leaves Using Hericium erinaceum Mycelia
Kim, Yon-Suk; Joung, Mi-Yeun; Ryu, Beom-Seok; Park, Pyo-Jam; Jeong, Jae-Hyun;
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This study investigated the fermentation effect of Taraxacum platycarpum Dahlst. leaf extracts using Hericium ernaceum mycelia to test antioxidant and anti-inflammatory activities in vitro. The antioxidant activities of fermented or non-fermented extracts of T. platycarpum leaves were determined by 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, ferric reducing antioxidant power, and 2,2`-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity. The leaf extract of T. platycarpum showed higher antioxidant activity than extract of fermented leaves. However, ethanolic extract of fermented T. platycarpum leaves decreased levels of nitric oxide production and pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor- in lipopolysaccharide-stimulated RAW 264.7 cells. Moreover, fermented leaf extract suppressed protein expression of inducible nitric oxide synthase in RAW 264.7 cell culture. Therefore, the enhanced anti-inflammatory activity of ethanolic extracts of fermented T. platycarpum leaves might be attributed to the molecular conversion of leaf ingredients during fermentation and the active ingredients might have specific affinity with ethanol during extraction.
antioxidant activity;anti-inflammatory effect;Taraxacum platycarpum D.;Hericium erinaceum mycelia;
 Cited by
Kang MJ, Kim KS. 2001. Current trends of research and biological activities of dandelion. Food Industry and Nutrition 6(3): 60-67.

Chon SU. 2012. Antioxidant activity and cytotoxicity of different Taraxacum species in Korea. Korean J Crop Sci 57: 51-59. crossref(new window)

Williams CA, Goldstone F, Greenham J. 1996. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. Phytochemistry 42: 121-127. crossref(new window)

Bradley P. 1992. British herbal compendium: A handbook of scientific information on widely used plant drugs. British Herbal Medicine Association, Bournemouth, UK. Vol 1, p73.

Gonzalez-Castejon M, Visioli F, Rodriguez-Casado A. 2012. Diverse biological activities of dandelion. Nutr Rev 70: 534-547. crossref(new window)

Racz-Kotilla E, Racz G, Solomon A. 1974. The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals. Planta Med 26: 212-217. crossref(new window)

Jo JW. 1999. Compositae 10. In Encyclopedia of Oriental Medicine. Kyung Hee University Press, Seoul, Korea. p 514.

Han EK, Lee JY, Jung EJ, Jin YX, Chung CK. 2010. Antioxidative activities of water extracts from different parts of Taraxacum officinale. J Korean Soc Food Sci Nutr 39: 1580-1586. crossref(new window)

Han EK, Jung EJ, Lee JY, Jin YX, Chung CK. 2011. Antioxidative activity of ethanol extracts from different parts of Taraxacum officinale. J Korean Soc Food Sci Nutr 40: 56-62. crossref(new window)

Kim HW, Kim BJ, Lim SH, Kim HY, Lee SY, Cho SI, Kim YK. 2009. Anti-oxidative effects of taraxaci herba and protective effects on human HaCat keratinocyte. Kor J Herbology 24: 103-108.

Lim AK, Kim JO, Jung MJ, Jung HK, Hong JH, Kim DI. 2008. Functional biological activity of hot water and ethanol extracts from Taraxaci Herba. J Korean Soc Food Sci Nutr 37: 1231-1237. crossref(new window)

Lee DS, Li B, Lee YJ, Chun HJ, Ryu IW, Jae YJ, Chae GU, Kwon YS, Shon JU, Kang HG, Lee SH, An RB, Lee HS. 2011. Anti-inflammatory effect of extracts from the roots of Taraxacum coreanum on lipopolysaccharide-induced inflammation in BV2 cells. Kor J Oral Maxillofac Pathol 35: 231-238.

Back HU. 2003. In vitro free radical scavenging and hepatoprotective activities of Taraxacum mongolicum. Kor J Pharmacogn 34:4 324-326.

Duke JA. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. In Herbal Reference Library. CRC Press, Boca Raton, FL, USA. p 587-589.

Kang MG, Jo WS, Kim WH, Choi SY, Park SD. 2015. The difference of occurring pattern of Hericium erinaceus by pinheading induction methods. J Mushrooms 13: 11-15. crossref(new window)

Ha JH, Jeong HS, Oh SH, Jeong SS, Jeong MH, Jeong HS, Jeong JH, Yu KW, Lee HY. 2009. Comparison of immuno activities of fresh ginseng cultured Phelinus linteus and Hericium erinaceum mycelium associated with ultrasonification extraction. Korean J Medicinal Crop Sci 17: 311-320.

Park CK, Kim H, Tu Qi, Yu KW, Jeong HS, Lee HY, Jeong JH. 2009. Chemical composition and immunostimulating activity of the fermented Korean ginseng (Panax ginseng C.A. Meyer) with mushroom mycelium by solid culture. J Korean Soc Food Sci Nutr 38: 1145-1152. crossref(new window)

Jang JY, Shin S, Choi B, Park D, Jeon JH, Cho YM, Cho JH, Jung DH, Hwang SY, Ahn B, Jeong MS, Jeong JH, Kim YB. 2006. Effects of $Erinacol^{(R)}$, extract of Hericium erinacium cultivated with Artemisia iwayomogi, on alcoholic hangover and immune function. Lab Anim Res 22: 157-163.

Shin S, Jang JY, Choi B, Jeon JH, Ji HJ, Moon SH, Jung DH, Yeo YG, Baek SJ, Hwang SY, Chung JH, Kin YB. 2006. Effects of $Erinacol^{(R)}$, extract of Hericium erinacium cultivated with Artemisia iwayomogi, on alcoholic fatty liver. Lab Anim Res 22: 165-170.

Choi BI, Shin SH, Jang JY, Park DS, Kang DH, Nahm SS, Yeo YG, Cho JH, Hwang SY, Jeong MS, Jeong JH, Kim YB. 2006. Single- and repeated-dose toxicities of $Erinacol^{(R)}$, extract of Hericium erinacium cultivated with Artemisia iwayomogi, in rats. Lab Anim Res 22: 171-179.

Gutfinger T. 1981. Polyphenols in olive oils. J Am Oil Chem Soc 58: 966-968. crossref(new window)

Zhishen J, Mengcheng T, Jianming W. 1999. The determination of flavonoid content in mulberry and their scavenging effects on superoxide radicals. Food Chem 64: 555-559. crossref(new window)

Blois MS. 1958. Antioxidant determinations by the use of a stable free radical. Nature 1181: 1199-1200.

Park MK, Kim CH. 2009. Extraction of polyphenols from apple peel using cellulase and pectinase and estimation of antioxidant activity. J Korean Soc Food Sci Nutr 38: 535-540. crossref(new window)

Benzie IF, Strain JJ. 1999. Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol 299: 15-27. crossref(new window)

Titheradge MA. 1998. The enzymatic measurement of nitrate and nitrite. Methods Mol Biol 100: 83-91.

Kim YS, Lee SJ, Hwang JW, Kim EH, Park PJ, Jeong JH. 2012. Anti-inflammatory effects of extracts from Ligustrum ovalifolium H. leaves on RAW264.7 macrophages. J Korean Soc Food Sci Nutr 41: 1205-1210. crossref(new window)

Kim JS, Jeong JY, Nam JB, Oh JS, Yun CY, Ha SY, Choi MS, Yang JK. 2011. Polyphenol absorption potential in Lentinula edodes mycelium growth. Mushroom 15: 49.

Jun DH, Lee JT, Cheon SJ, Kim TH, Lee DH, Han J, Kim SH. 2009. Polyphenol and anti-oxidant effects of Kalopanax septemlobus Koidz. leaf extracts. Korean J Plant Res 22: 343-348.

Park MR, Yoo C, Chang YN, Ahn BY. 2012. Change of total polyphenol content of fermented Gastrodia elata Blume and radical scavenging. Korean J Plant Res 25: 379-386. crossref(new window)

Shon MY. 2007. Antioxidant and anticancer activities of Poria cocos and Machilus thunbergii fermented with mycelial mushrooms. Food Industry and Nutrition 12(2): 51-57.

Tenhunen R, Marver HS, Schmid R. 1970. The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin. J Lab Clin Med 75: 410-421.

Knowles RG, Moncada S. 1994. Nitric oxide synthases in mammals. Biochem J 298: 249-258. crossref(new window)

Yoon WJ, Lee JA, Kim KN, Kim JY, Park SY. 2007. In vitro anti-inflammatory activity of the Artemisia fukudo extracts in murine macrophage RAW 264.7 cells. Korean J Food Sci Technol 39: 464-469.

Han J, Kim Y, Sung J, Um Y, Lee Y, Lee J. 2009. Suppressive effects of Chrysanthemum zawadskii var. latilobum flower extracts on nitric oxide production and inducible nitric oxide synthase expression. J Korean Soc Food Sci Nutr 38: 1685-1690. crossref(new window)