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Anti-Inflammatory Effect of Chondrus nipponicus Yendo Ethanol Extract on Lipopolysaccharide-Induced Inflammatory Responses in RAW 264.7 Cells
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 Title & Authors
Anti-Inflammatory Effect of Chondrus nipponicus Yendo Ethanol Extract on Lipopolysaccharide-Induced Inflammatory Responses in RAW 264.7 Cells
Kim, Min-Ji; Bae, Nan-Yong; Kim, Koth-Bong-Woo-Ri; Park, Ji-Hye; Park, Sun-Hee; Jang, Mi-Ran; Ahn, Dong-Hyun;
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The anti-inflammatory activity of ethanol extract from Chondrus nipponicus Yendo (CNYEE) was investigated by measuring production of a lipopolysaccharide-induced inflammatory response mediator. CNYEE had no cytotoxic effects on proliferation of macrophages compared to the control. CNYEE significantly inhibited (over 50%) NO production at , with inhibitory effects on expression levels of cytokines such as interleukin (IL)-6, tumor necrosis factor- (TNF-), and IL-. In particular, IL-6 inhibitory activity of CNYEE was higher than 70% at . CNYEE also reduced protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor (NF)- in a dose-dependent manner. CNYEE also significantly reduced phosphorylation of p38, extracellular signal-regulated kinase, and c-Jun N-terminal kinase. Therefore, these results suggest that CNYEE may have anti-inflammatory effects by modulating the NF- and mitogen-activated protein kinases signaling pathways and may be used as an anti-inflammatory therapeutic material.
Chondrus nipponicus Yendo;anti-inflammatory;cytokine;MAPKs;
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LPS로 유도된 RAW 264.7 세포와 마우스 귀 조직에 대한 주름까막살 에탄올 추출물의 항염증 효과,배난영;김민지;김꽃봉우리;박선희;장미란;안동현;

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