Publisher : The Korean Society of Food Science and Nutrition
DOI : 10.3746/jkfn.2016.45.2.293
Title & Authors
Inhibitory Effects of Transglycoslyation Products of Soy Isoflavones on Cholesterol Biosynthesis Yoo, Lang Kuk; Choi, Seung Jun; Moon, Tae Wha; Shim, Jae-Hoon;
Hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) is the rate-limiting enzyme in biosynthesis of cholesterol in animals. In this study, inhibitory effects of isoflavone glycosides on HMG-CoA reductase were investigated. At sample concentration of , genistein-7-O-triglucoside (G2-genistin) inhibited HMG-CoA reductase activity by approximately 18%, whereas daidzein-7-O-triglucoside had no inhibitory effect. In the kinetic experiments with Syrian hamster HMG-CoA reductase, G2-genistin showed inhibitory efficacy with an invariable value, suggesting that G2-genistin works as a competitive inhibitor of HMG-CoA reductase and has potential for hypocholesterolemic action through direct regulation of HMG-CoA reductase.
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