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Safety Study of Yeast Hydrolysate on a Postmenopausal Animal Model
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 Title & Authors
Safety Study of Yeast Hydrolysate on a Postmenopausal Animal Model
Jung, Eun-Young;
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 Abstract
The objective of this study was to obtain data on safety-in-use of yeast hydrolysate with a molecular weight of 10~30 kDa as a dietary supplement by assessing its subacute oral toxicity in ovariectomized rats. Yeast hydrolysate did not produce mortality or significant changes in general behavior or gross appearance of internal organs of rats. There were no significant differences in organ weights between control and yeast hydrolysate groups. Hematological analysis and blood chemistry revealed no toxic effects of yeast hydrolysate. Neither gross abnormalities nor histopathological changes were observed. These results show that yeast hydrolysate possesses very low toxicity as indicated in a postmenopausal animal model.
 Keywords
yeast hydrolysate;safety study;toxicity;postmenopause;
 Language
Korean
 Cited by
 References
1.
Imthurn B, Maurer-Major E. 2000. Climacteric syndrome. Ther Umsch 57: 595-599. crossref(new window)

2.
Delcominette S, Gaspard U. 2008. Female sexual dysfunction and postmenopausal androgen therapy. Rev Med Liege 63: 23-30.

3.
Polisseni AF, de Araujo DA, Polisseni F, Mourao Junior CA, Polisseni J, Fernandes ES, Guerra Mde O. 2009. Depression and anxiety in menopausal women: associated factors. Rev Bras Ginecol Obstet 31: 28-34. crossref(new window)

4.
Albertazzi P. 2007. Non-estrogenic approaches for the treatment of climacteric symptoms. Climacteric 10(Suppl 2): 115-120. crossref(new window)

5.
Harrison RF, Bonnar J. 1980. Clinical uses of estrogens. Pharmacol Ther 11: 451-467. crossref(new window)

6.
Suh HJ, Kim SY, Chang UJ, Kim JM. 2008. Anti-stress effects of chewing gum prepared with yeast hydrolysate. Eur Food Res Technol 227: 331-336. crossref(new window)

7.
Yu KW, Oh SH, Choi YS, Hwang WJ, Suh HJ. 2001. The reduction effect of yeast hydrolysate SCP-20 premenstrual syndrome. J Korean Soc Food Sci Nutr 30: 1000-1003.

8.
Yu KW, Kim JM, Oh SH, Chang UJ, Suh HJ. 2002. Physiological effects of yeast hydrolysate SCP-20. Food Res Int 35: 879-884. crossref(new window)

9.
Kim JM, Lee SW, Kim KM, Chang UJ, Song JC, Suh HJ. 2003. Anti-stress effect and functionality of yeast hydrolysate SCP-20. Eur Food Res Technol 217: 168-172. crossref(new window)

10.
Hong JW, Kim IH, Yoo SH, Lee HS, Kwon OS, Min BJ, Lee WB, Shon KS, Kim JM. 2004. The effects of yeast hydrolysate SCP-20 on reproductive function in male mice. J Korean Soc Food Sci Nutr 33: 451-454. crossref(new window)

11.
Jung EY, Kang DH, Suh HJ, Chang UJ. 2009. Effects of yeast hydrolysate on neuropeptide Y (NPY) and tryptophan hydroxylase (TPH) immunoreactivity in rats. Phytother Res 23: 619-623. crossref(new window)

12.
Jung EY, Suh HJ, Kim SY, Hong YS, Kim MJ, Chang UJ. 2008. Appetite suppressive effects of yeast hydrolysate on nitric oxide synthase (NOS) expression and vasoactive intestinal peptide (VIP) immunoreactivity in hypothalamus. Phytother Res 22: 1417-1422. crossref(new window)

13.
Kim JM, Kim SY, Jung EY, Bae SH, Suh HJ. 2009. Yeast hydrolysate induces longitudinal bone growth and growth hormone release in rats. Phytother Res 23: 731-736. crossref(new window)

14.
Kim KM, Chang UJ, Kang DH, Kim JM, Choi YM, Suh HJ. 2004. Yeast hydrolysate reduces body fat of dietary obese rats. Phytother Res 18: 950-953. crossref(new window)

15.
Jung EY, Lee HS, Choi JW, Ra KS, Kim MR, Suh HJ. 2011. Glucose tolerance and antioxidant activity of spent brewer's yeast hydrolysate with a high content of Cyclo-His-Pro (CHP). J Food Sci 76: C272-C278. crossref(new window)

16.
Jung EY, Lee HS, Chang UJ, Bae SH, Kwon KH, Suh HJ. 2010. Acute and subacute toxicity of yeast hydrolysate from Saccharomyces cerevisiae. Food Chem Toxicol 48: 1677- 1681. crossref(new window)

17.
Jung EY, Park SS, Kim JH, Chang UJ, Bae SH, Choi JW, Suh HJ. 2011. Safety study of yeast hydrolysate with below 10 kDa molecular weight in animal models. J Health Sci 57: 532-539. crossref(new window)

18.
Lillie LE, Temple NJ, Florence LZ. 1996. Reference values for young normal Sprague-Dawley rats: weight gain, hematology and clinical chemistry. Hum Exp Toxicol 15: 612-616. crossref(new window)

19.
Jung EY, Lee HS, Seo HC, Suh HJ. 2010. Safety evaluation of yeast hydrolysate (Notress). J Microb Biochem Technol 2: 58-63. crossref(new window)