JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Enhancing Effect of Pteridium aquilinum and Aster scaber Added Doenjang on Immunomodulatory Activity
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Enhancing Effect of Pteridium aquilinum and Aster scaber Added Doenjang on Immunomodulatory Activity
Sung, Nak-Yun; An, Eun-Ju; Park, Won-Jong; Park, Woo-Young; Byun, Eui-Hong;
  PDF(new window)
 Abstract
This study demonstrated the immunological effects of methanol extracts from Doenjang added with wild plants (Pteridium aquilinum and Aster scaber) on bone-marrow derived macrophages and mouse splenocytes. Doenjang (DJ) and wild plant added Doenjang (WPDJ) extracts were treated to bone-marrow derived macrophages (BMDM) and splenocytes, and cell proliferation and cytokine production were measured. Cell proliferation of BMDM and splenocytes was more highly elevated in the WPDJ-treated group compared to the DJ-treated group. Cytokine [tumor necrosis factor (TNF)-, interleukin (IL)-6, IL-, IL-10, and IL-12] production in BMDM also significantly increased in the WPDJ-treated group. Similarly, in the case of cytokine production in splenocytes, WPDJ treatment highly increased production of Th 1 type cytokines [interferon (IFN)- and IL-2] but did not affect production of Th 2 type cytokines (IL-4). These results suggest that wild plants could improve the immunomodulatory activity of Doenjang and may be effective for the development Doenjang.
 Keywords
wild plant;immune enhancing activity;bone-marrow derived macrophage;splenocyte;cytokine;
 Language
Korean
 Cited by
 References
1.
Kim MJ, Lee HS. 1990. Studies on the changes of taste compounds during soy paste fermentation (III). Korean J Soc Food Sci 9: 261-265.

2.
Kurechi T, Kikugawa K, Fukuda S, Hasunuma M. 1981. Inhibition of N-nitrosamine formation by soya products. Food Cosmet Toxicol 19: 425-428. crossref(new window)

3.
Yu R, Park SA, Chung DK, Nam HS, Shin ZI. 1996. Effect of soybean hydrolysate on hypertension in spontaneously hypertensive rats. J Korean Soc Food Sci Nutr 25: 1031-1036.

4.
Fang YZ, Yang S, Wu G. 2002. Free radicals, antioxidants, and nutrition. Nutrition 18: 872-879. crossref(new window)

5.
Park KY, Moon SH, Cheigh HS, Baik HS. 1996. Antimutagenic effects of Doenjang (Korean soy paste). J Food Sci Nutr 1: 151-156.

6.
Messina M. 1995. Modern applications for an ancient bean: soybeans and the prevention and treatment of chronic disease. J Nutr 125: 567S-569S.

7.
Lee JJ, Lee YM, Chang HC, Lee MY. 2009. Antioxidative effects of doenjang fermented using Bacillus subtilis DJI. Korean J Food Preserv 16: 554-561.

8.
Jang SM, Lee JB, An H, Rhee CH, Park HD. 2000. Changes of microorganisms, enzyme activity and physiological functionality in the Korean soybean paste with various concentrations of ginseng extract during fermentation. Korean J Postharvest Sci Technol 7: 313-320.

9.
Jeong MW, Jeong JK, Kim SJ, Park KY. 2013. Fermentation characteristics and increased functionality of doenjang prepared with bamboo salt. J Korean Soc Food Sci Nutr 42: 1915-1923. crossref(new window)

10.
Kim YD, Yang WM. 1986. Studies on the components of wild vegetables in Korea. J Korean Soc Food Nutr 15: 10-16.

11.
Ham SS, Lee SY, Choi M, Hwang Bo HJ. 1998. Antimutagenicity and cytotoxicity effects of woorimil wheat flour extracts added with wild herb and seaweed powder. J Korean Soc Food Sci Nutr 27: 1177-1182.

12.
Bae JH, Yu SO, Kim YM, Chon SU, Kim BW, Heo BG. 2009. Physiological activity of methanol extracts from Ligularia fischeri and their hyperplasia inhibition activity of cancer cell. J Bio-Environ Control 18: 67-73.

13.
Whang TE, Lim HO, Lee JW. 1999. Effect of fermented (Oenanthe stolonifera DC) extract on the activity of enzymes related to liver function of alcohol-administered rats and mice. Korean J Med Crop Sci 7: 107-114.

14.
Lee SO, Lee HJ, Yu MH, Im HG, Lee IS. 2005. Total polyphenol contents and antioxidant activities of methanol extracts from vegetables produced in Ullung Island. Korean J Food Sci Technol 37: 233-240.

15.
Kim EY, Jung EY, Lim HS, Heo YR. 2007. The effects of the Sasa borealis leaves extract on plasma adiponectin, resistin, C-reactive protein and homocysteine levels in high fat diet-induced obese C57/BL6J mice. Korean J Nutr 40: 303-311.

16.
Choi J, Kim WB, Nam JH, Park HJ. 2007. Anti-diabetic effect of the methanolic extract of Ligularia stenocephala leaves in the streptozotocin-induced rat. Korean J Plant Res 20: 362-366.

17.
Moon YG, Choi KS, Lee KJ, Kim KY, Heo MS. 2006. Screening of antioxidative and antibacterial activity from hot water extracts of indigenous plants, Jeju-Island. Korean J Biotechnol Bioeng 21: 164-169.

18.
Koh YJ, Park YK, Kim YS, Cha DS, Choi HD. 2009. Preparation of hot water extracts of dandelion leaves to increase anti-inflammatory activity. J Korean Soc Food Sci Nutr 38: 391-395. crossref(new window)

19.
Kweon MH, Kim HI, Sung HC, Yang HC. 1994. Core structure of the anti-complementary acidic polysaccharide (PAIIa- 1) isolated from water extract of Pteridium aquilinum var. latiusculum. Foods Biotechnol 3: 137-143.

20.
Kweon MH, Sung HC. 1996. Structural comparison in the four anti-complementary polysaccharides isolated from Pteridium aquilinum var. latiusculum (bracken). Foods Biotechnol 5: 136-141.

21.
Hur JY, Soh Y, Kim BH, Suk K, Sohn NW, Kim HC, Kwon HC, Lee KR, Kim SY. 2001. Neuroprotective and neurotrophic effects of quinic acids from Aster scaber in PC12 cells. Biol Pharm Bull 24: 921-924. crossref(new window)

22.
Kim K, Sohn H, Kim JS, Choi HG, Byun EH, Lee KI, Shin SJ, Song CH, Park JK, Kim HJ. 2012. Mycobacterium tuberculosis Rv0652 stimulates production of tumour necrosis factor and monocytes chemoattractant protein-1 in macrophages through the Toll-like receptor 4 pathway. Immunology 136: 231-240. crossref(new window)

23.
Green LM, Reade JL, Ware CF. 1984. Rapid colormetric assay for cell viability: Application to the quantitation of cytotoxic and growth inhibitory lymphokines. J Immunol Methods 70: 257-268. crossref(new window)

24.
Hoebe K, Janssen E, Beutler B. 2004. The interface between innate and adaptive immunity. Nat Immunol 5: 971-974.

25.
Sunderkotter C, Steinbrink K, Goebeler M, Bhardwaj R, Sorg C. 1994. Macrophages and angiogenesis. J Leukoc Biol 55: 410-422.

26.
Morel F, Doussiere J, Vignais PV. 1991. The superoxidegenerating oxidase of phagocytic cells. Physiological, molecular and pathological aspects. Eur J Biochem 201: 523-546. crossref(new window)

27.
Ramesh HP, Yamaki K, Tsushida T. 2002. Effect of fenugreek (Trigonella foenum-graecum L.) galactomannan fractions on phagocytosis in rat macrophages and on proliferation and IgM secretion in HB4C5 cells. Carbohyd Polym 50: 79-83. crossref(new window)

28.
Yoon HJ, Moon ME, Park HS, Im SY, Lee JH, Kim YH. 2007. Effects of chitosan oligosaccharide on the C. albicans- induced inflammatory effect in mice and RAW 264.7 macrophage cells. J Chitin Chitosan 12: 15-20.

29.
Delgado AV, McManus AT, Chambers JP. 2003. Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P. Neuropeptides 37: 355-361. crossref(new window)

30.
Cyster JG. 1999. Chemokines and cell migration in secondary lymphoid organs. Science 286: 2098-2102. crossref(new window)

31.
Zalys R, Zagon IS, Bonneau RH, Lang CM, McLaughlin PJ. 2000. In vivo effects of chronic treatment with [Met5]- enkephalin on hematological values and natural killer cell activity in athymic mice. Life Sci 66: 829-834. crossref(new window)

32.
Medzhitov R. 2001. Toll-like receptors and innate immunity. Nat Rev Immunol 1: 135-145. crossref(new window)