JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Effects of Colpomenia sinuosa Extract on Serum Lipid Level and Bone Formation in Ovariectomized Rats
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Effects of Colpomenia sinuosa Extract on Serum Lipid Level and Bone Formation in Ovariectomized Rats
Lee, Juyeong; Kim, Bokyung; Park, Mi-Hwa; Choi, Kyung-Ha; Kong, Changsuk; Lee, Sang-Hyeon; Kim, Yuck Yong; Yu, Ki Hwan; Kim, Mihyang;
  PDF(new window)
 Abstract
In this study, the effects of Colpomenia sinuosa (CS) extract on serum lipid level and bone formation in an ovariectomized animal model were investigated. Twenty four nine-week old female Sprague-Dawley rats were randomly assigned to four groups: sham-operated rats (SHAM), ovariectomized control rats (OVX-CON), and ovariectomized rats supplemented with CS extract at 50 mg/kg bw (OVX-CS50) or 200 mg/kg bw (OVX-CS200). Three OVX groups were surgically ovariectomized while the SHAM group was sham-operated. CS extract was orally administrated at 1 mL per day. Analysis of serum lipid contents found that the total cholesterol, triglyceride, and low density lipoprotein cholesterol levels in the OVX-CON group were higher than those in the SHAM group. Notably, upon administration of CS extract after ovariectomy, triglyceride levels tended to significantly decrease. In addition, platelet aggregation ability decreased in groups treated with CS extract compared to the OVX-CON group. Serum alkaline phosphatase activity as an indicator of bone formation was lower in the CS extract group compared to the OVX-CON group. Collagen contents in bone and cartilage were reduced by ovariectomy, whereas the CS extract-supplemented groups exhibited higher concentrations in bone. According to these results, CS extract improved serum lipid parameters and osteogenesis in ovariectomized rats.
 Keywords
Colpomenia sinuosa;collagen;ovariectomized rats;platelet aggregation;serum lipids;
 Language
Korean
 Cited by
 References
1.
Phang H, Lee D. 2015. Population aging and changes of labour market in East Asia. Korea J Population Studies 38(4): 1-32.

2.
Hwang MJ, Jung SH. 2011. The ageing society of Korea and the population estimate. Korea J Population Studies 34(2): 113-133.

3.
Poehlman ET, Toth MJ, Gardner AW. 1995. Changes in energy balance and body composition at menopause: a controlled longitudinal study. Ann Intern Med 123: 673-675. crossref(new window)

4.
Toth MJ, Tchernof A, Sites CK, Poehlman ET. 2000. Menopause-related changes in body fat distribution. Ann N Y Acad Sci 904: 502-506.

5.
Zamboni M, Armellini F, Milani MP, De Marchi M, Todesco T, Robbi R, Bergamo-Andreis IA, Bosello O. 1992. Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships. Int J Obes Relat Metab Disord 16: 495-504.

6.
Carr MC. 2003. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab 88: 2404-2411. crossref(new window)

7.
Ford ES, Giles WH, Dietz WH. 2002. Prevalence of the metabolic syndrome among US adults. JAMA 287: 356-359. crossref(new window)

8.
Ministry of Health & Welfare. 2010. National nutrition survey. Seoul, Korea.

9.
Kim YS, Kim YS, Park YM, Lee JI. 2015. Relationship between serum lipid profile and bone mineral density in postmenopausal Korean women: The 4th (2008-2009) and 5th (2010-2011) Korea Health and Nutrition Examination Surveys (KNHANES IV & V). Korean J Fam Pract 5:150-157.

10.
Rodan GA, Martin TJ. 2000. Therapeutic approaches to bone diseases. Science 289: 1508-1514. crossref(new window)

11.
Anderson JJ, Garner SC. 1998. Phytoestrogens and bone. Baillieres Clin Endocrinol Metab 12: 543-557. crossref(new window)

12.
Tsai JN, Uihlein AV, Lee H, Kumbhani R, Siwila-Sackman E, McKay EA, Burnett-Bowie SA, Neer RM, Leder BZ. 2013. Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial. Lancet 382: 50-56. crossref(new window)

13.
Catalano A, Morabito N, Basile G, Brancatelli S, Cucinotta D, Lasco A. 2013. Zoledronic acid acutely increases sclerostin serum levels in women with postmenopausal osteoporosis. J Clin Endocrinol Metab 98: 1911-1915. crossref(new window)

14.
Lim S, Leem JY, Lee CS, Jang YJ, Park JW, Yoon S. 2007. Antioxidant and cell proliferation effects of Acanthopanax senticosus extract in human osteoblast-like MG-63 cell line. Korean J Food Sci Technol 39: 694-700.

15.
Park YS. 2011. Effects of Eisenia bicyclis extracts on lipids and bone turnover in ovariectomized rats. MS Thesis. Silla University, Busan, Korea.

16.
Cha SH, Ahn GN, Heo SJ, Kim KN, Lee KW, Song CB, Cho SK, Jeon YJ. 2006. Screening of extracts from marine green and brown algae in Jeju for potential marine angiotensin-I converting enzyme (ACE) inhibitory activity. J Korean Soc Food Sci Nutr 35: 307-314. crossref(new window)

17.
Kim DS, Lee DS, Cho DM, Kim HR, Pyeun JH. 1995. Trace components and functional saccharides in marine algae: 2. Dietary fiber contents and distribution of the algal polysaccharides. J Korean Fish Soc 28: 270-278.

18.
Kim KI, Seo HD, Lee HS, Jo HY, Yang HC. 1998. Studies on the blood anticoagulant polysaccharide isolated from hot water extracts of Hijikia fusiforme. J Korean Soc Food Sci Nutr 27: 1204-1210.

19.
Lee YP. 2005. New records of marine algae from Jeju Island, Korea. J Fish Sci Technol 8: 97-108.

20.
Kang SR, Kim MH. 2009. The effect of Ecklonia cava extracts on bone turnover markers in ovariectomized rats. J Life Sci 19: 1841-1846. crossref(new window)

21.
Kim YK, Kim MH. 2010. Effect of Ecklonia stolonifera extracts on bone turnover markers in ovariectomized rats. J Korean Soc Food Sci Nutr 39: 1769-1775. crossref(new window)

22.
Park YS, Kang MS, Kim BK, Kim M. 2013. The effect of Eisenia bicyclis extracts on bone tissues in ovariectomized rats. J Korean Soc Food Sci Nutr 42: 33-39. crossref(new window)

23.
Kim CS, Kim YS, Choi HG, Nam KW. 2014. Variations of seaweed community structure and distribution of crustose coralline algae at Gallam, Samchuk, eastern coast of Korea. Korean J Environ Ecol 28: 10-23. crossref(new window)

24.
Shin DB, Han EH, Park SS. 2014. Cytoprotective effects of phaeophyta extracts from the coast of Jeju Island in HT-22 mouse neuronal cells. J Korean Soc Food Sci Nutr 43:224-230. crossref(new window)

25.
Kimble RB, Vannice JL, Bloedow DC, Thompson RC, Hopfer W, Kung VT, Brownfield C, Pacifici R. 1994. Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats. J Clin Invest 93: 1959-1967. crossref(new window)

26.
Schiele F, Henny J, Hitz J, Petitclerc C, Gueguen R, Siest G. 1983. Total bone and liver alkaline phosphatases in plasma: biological variations and reference limits. Clin Chem 29: 634-641.

27.
Raisz LG. 1988. Local and systemic factors in the pathogenesis of osteoporosis. N Engl J Med 318: 818-828. crossref(new window)

28.
Woessner JF. 1961. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 93: 440-447. crossref(new window)

29.
Frolik CA, Bryant HU, Black EC, Magee DE, Chandrasekhar S. 1996. Time-dependent changes in biochemical bone markers and serum cholesterol in ovariectomized rats: effects of raloxifene HCl, tamoxifen, estrogen, and alendronate. Bone 18: 621-627. crossref(new window)

30.
Kalu DN, Arjmandi BH, Liu CC, Salih MA, Birnbaum RS. 1994. Effects of ovariectomy and estrogen on the serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3. Bone Miner 25: 135-148. crossref(new window)

31.
Lee YB, Lee HJ, Kim KS, Lee JY, Nam SY, Cheon SH, Sohn HS. 2004. Evaluation of the preventive effect of isoflavone extract on bone loss in ovariectomized rats. Biosci Biotechnol Biochem 68: 1040-1045. crossref(new window)

32.
Mueller K, Hsiao S. 1980. Estrus- and ovariectomy-induced body weight changes: evidence for two estrogenic mechanisms. J Comp Physiol Psychol 94: 1126-1134. crossref(new window)

33.
Okazaki R, Inoue D, Shibata M, Saika M, Kido S, Ooka H, Tomiyama H, Sakamoto Y, Matsumoto T. 2002. Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) ${\alpha}$ or ${\beta}$. Endocrinology 143: 2349-2356.

34.
O JH, Lee YS. 1993. Effects of dietary calcium levels on the reduction of calcium availability in ovariectomized osteoporosis model rats. Korean J Nutr 26: 277-285.

35.
Kim SY. 2015. Effects of Scytosiphon lomentaria extracts on bone formation in vivo and in vitro test. MS Thesis. Silla University, Busan, Korea. p 61.

36.
Sontas HB, Dokuzeylu B, Turna O, Ekici H. 2009. Estrogeninduced myelotoxicity in dogs: A review. Can Vet J 10:1054-1058.

37.
Wu Q, Zhao Z, Sun H, Hao YL, Yan CD, Gu SL. 2008. Oestrogen changed cardiomyocyte contraction and betaadrenoceptor expression in rat hearts subjected to ischaemia-reperfusion. Exp Physiol 93:1034-1043. crossref(new window)

38.
Ross RK, Paganini-Hill A, Mark TM, Henderson BE. 1989. Cardiovascular benefits of estrogen replacement therapy. Am J Obstet Gynecol 160: 1301-1306. crossref(new window)

39.
Coulam CB, Ryan RJ. 1979. Premature menopause. Am J Obstet Gynecol 133: 639-643. crossref(new window)

40.
Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. 1977. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med 62: 707-714. crossref(new window)

41.
Namkung J, Kim JH, Jo HH, Oh EK, Cheon KY, Kwon DJ, Lew YO, Kim EJ, Hwang SJ, Song JY, Kim MJ, Kim MR. 2010. Comparison of the effects of hormone replacement therapy on bone mineral density, lipid profiles, and biochemical markers of bone metabolism. J Korean Soc Menopause 16: 107-115.

42.
Yu CK. 2003. Serum lipid profile and body weight changes after hormone replacement therapy in postmenopausal women. MS Thesis. Dongduk Women's University, Seoul, Korea. p 56.

43.
Lee JH, Baik IK, Kim HS, Cha BS, Lee HC, Huh KB. 1997. Body fat distribution and serum levels of lipids and hormones in pre- and post-menopausal women. Korean J Lipidology 7: 155-164.

44.
Jae SY, Park WH. 1998. The relationship of cardiopulmonary fitness to plasma fibrinogen, plasminogen activator inhibitor type-1 (PAI-1), and lipoprotein (a) [LP(a)] in healthy postmenopausal women. Korean J Sports Med 16: 282-291.

45.
Lee YA, Kim M. 2008. The effect of sea tangle extract on serum lipid level in ovariectomized rats. J Life Sci 18: 249-254. crossref(new window)

46.
Park GH, Seo BS, Son DJ, Park YH, Jang SK 2003. Study on inhibition of platelet aggregation of bioactive constituents from Paeonia lactiflora. J Korea Acad Industr Coop Soc 4: 357-360.

47.
Ryou SH 2008. Effects of ovariectomy or feeding green tea or sasa borealis bamboo after ovariectomy on plasma lipids, platelet aggregation, erythrocyte Na efflux and bone density in rats. MS Thesis. Jeju National University, Jeju, Korea. p 38.

48.
Khandwala HM, Mumm S, Whyte MP. 2006. Low serum alkaline phosphatase activity and pathologic fracture: case report and brief review of hypophosphatasia diagnosed in adulthood. Endocr Pract 12: 676-681. crossref(new window)

49.
Lubec G, Labudova O, Seebach D, Beck A, Hoeger H, Hermon M, Weninger M. 1995. Alpha-methyl-proline restores normal levels of bone collagen type I synthesis in ovariectomized rats. Life Sci 57: 2245-2252. crossref(new window)

50.
Tiku ML, Allison GT, Naik K, Karry SK. 2003. Malondialdehyde oxidation of cartilage collagen by chondrocytes. Osteoarthritis Cartilage 11: 159-166. crossref(new window)

51.
Kim DS, Park YH. 1985. Uronic acid composition, block structure and some related properties of alginic acid. Bull Korean Fish Soc 18: 29-36.

52.
Colliec S, Fischer AM, Tapon-Bretaudiere J, Boisson C, Durand P, Jozefonvicz J. 1991. Anticoagulant properties of a fucoidan fraction. Thromb Res 64: 143-154. crossref(new window)

53.
Koo JG, Jo KS, Do JR, Woo SJ. 1995. Isolation and purification of fucoidans from Laminaria religiosa and Undaria pinnatifida in Korea. J Korean Fish Soc 28: 227-236.

54.
Chizhov AO, Dell A, Morris HR, Haslam SM, McDowell RA, Shashkov AS, Nifant'ev NE, Khatuntseva EA, Usov AI. 1999. A study of fucoidan from the brown seaweed Chorda filum. Carbohydr Res 320: 108-119. crossref(new window)

55.
Kim BS, Kang HJ, Park JY, Lee J. 2015. Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells. Exp Mol Med 47: e128. crossref(new window)